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Postpartum Depression clinical trials recruiting in the U.S.

27 studies for Postpartum Depression are recruiting participants at sites across the United States.

Postpartum (post-pregnancy) depression can begin anytime within the first year after childbirth. Learn about the symptoms of postpartum depression.

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Recently updated studies

Ketamine Pharmacokinetics and Pharmacodynamics for Postpartum Depression and Pain After Cesarean Delivery

RecruitingPhase 1Healthy volunteers welcome
Ages 18 and older · All sexes · Updated Oct 2, 2026 · NCT06767566

SAINT in Postpartum Depression (PPD)

Recruiting
Ages 18 to 45 · Women · Updated Sep 28, 2026 · NCT07210255

Deconstructing Maternal Burdens: Doulas and the Community Unite for Health

Recruiting
Ages 15 to 49 · Women · Updated Sep 28, 2026 · NCT07799805

Accelerated TMS for Perinatal Depression

Recruiting
Ages 18 to 55 · Women · Updated Sep 18, 2026 · NCT06968390

Brexanolone Lifting Outcomes Of Moms

RecruitingPhase 3
Ages 15 to 45 · Women · Updated Sep 16, 2026 · NCT07822321

Maternal Stress on Human Milk and Infant Outcomes

Recruiting
Ages 18 to 50 · Women · Updated Sep 11, 2026 · NCT04821544

OBWELL: Innovative Psychotherapeutic Intervention to Treat Postpartum Depression

Recruiting
Ages 18 and older · Women · Updated Sep 8, 2026 · NCT06991166

A Long-Term Study of Patient-Reported Changes in Postpartum Depression Symptoms in People Starting Zuranolone

RecruitingObservational study
Ages 18 and older · Women · Updated Sep 8, 2026 · NCT07398469

Engage & Connect: A Psychotherapy for Postpartum Depression

Recruiting
All ages · Women · Updated Aug 20, 2026 · NCT05585164

Understanding the Role of Doulas in Supporting People With PMADs

RecruitingHealthy volunteers welcome
Ages 18 and older · Women · Updated Aug 14, 2026 · NCT05763537

Informing Implementation of a Circadian-Focused Intervention for Postpartum Depression

Recruiting
Ages 18 and older · Women · Updated Aug 14, 2026 · NCT07766161

Parents and Babies Pilot

Recruiting
Ages 18 and older · Women · Updated Aug 6, 2026 · NCT07607613

Implementation of a Clinical Decision Support Tool for Postpartum Depression

RecruitingHealthy volunteers welcome
Ages 18 and older · Women · Updated Jul 30, 2026 · NCT06818734

NICU Utilization of Remote Voice Technology to Improve mateRnal Experience (NURTURE)

RecruitingHealthy volunteers welcome
Ages 18 and older · Women · Updated Jun 17, 2026 · NCT07214597

Accelerated iTBS for Post Partum Depression

Recruiting
Ages 18 to 50 · Women · Updated May 22, 2026 · NCT03417960

The ROSE Scale-up Study: Informing a Decision About ROSE as Universal PPD Prevention

RecruitingHealthy volunteers welcome
Ages 18 and older · Women · Updated May 18, 2026 · NCT05700760

The Mom and Infant Outcomes (MOMI) Study

Recruiting
All ages · Women · Updated May 14, 2026 · NCT06277661

ROSE in Sunset Park

RecruitingHealthy volunteers welcome
Ages 18 to 100 · Women · Updated Mar 30, 2026 · NCT04940585

Clinical Validation of a Predictive Test for Postpartum Depression

RecruitingObservational studyHealthy volunteers welcome
Ages 18 and older · Women · Updated Dec 3, 2025 · NCT06831968

A Study of a Test for Postpartum Depression at Home

RecruitingObservational studyHealthy volunteers welcome
Ages 18 and older · Women · Updated Nov 28, 2025 · NCT07186309

Postpartum Care in the NICU (PeliCaN) Transitions

Recruiting
Ages 16 and older · Women · Updated Oct 14, 2025 · NCT06521398

Improving Maternal Sleep and Mental Health

RecruitingHealthy volunteers welcome
Ages 18 to 45 · Women · Updated Feb 10, 2025 · NCT06544941

The Dream Team: Testing Implementation of a Sleep Intervention for Perinatal Women Delivered by Direct Care Workers

RecruitingHealthy volunteers welcome
Ages 18 to 99 · All sexes · Updated Dec 27, 2024 · NCT06737055

Maternal Mental Health Access - MaMa

RecruitingHealthy volunteers welcome
Ages 18 and older · Women · Updated Dec 6, 2024 · NCT06049433

From ClinicalTrials.gov, data retrieved Oct 5, 2026. Each study sets its own eligibility; the study team decides who can join.