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Postpartum Depression clinical trials recruiting in the U.S.
27 studies for Postpartum Depression are recruiting participants at sites across the United States.
Postpartum (post-pregnancy) depression can begin anytime within the first year after childbirth. Learn about the symptoms of postpartum depression.
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Recently updated studies
Ketamine Pharmacokinetics and Pharmacodynamics for Postpartum Depression and Pain After Cesarean Delivery
RecruitingPhase 1Healthy volunteers welcome
Ages 18 and older · All sexes · Updated Oct 2, 2026 · NCT06767566SAINT in Postpartum Depression (PPD)
Recruiting
Ages 18 to 45 · Women · Updated Sep 28, 2026 · NCT07210255Deconstructing Maternal Burdens: Doulas and the Community Unite for Health
Recruiting
Ages 15 to 49 · Women · Updated Sep 28, 2026 · NCT07799805Accelerated TMS for Perinatal Depression
Recruiting
Ages 18 to 55 · Women · Updated Sep 18, 2026 · NCT06968390Brexanolone Lifting Outcomes Of Moms
RecruitingPhase 3
Ages 15 to 45 · Women · Updated Sep 16, 2026 · NCT07822321Maternal Stress on Human Milk and Infant Outcomes
Recruiting
Ages 18 to 50 · Women · Updated Sep 11, 2026 · NCT04821544OBWELL: Innovative Psychotherapeutic Intervention to Treat Postpartum Depression
Recruiting
Ages 18 and older · Women · Updated Sep 8, 2026 · NCT06991166A Long-Term Study of Patient-Reported Changes in Postpartum Depression Symptoms in People Starting Zuranolone
RecruitingObservational study
Ages 18 and older · Women · Updated Sep 8, 2026 · NCT07398469Engage & Connect: A Psychotherapy for Postpartum Depression
Recruiting
All ages · Women · Updated Aug 20, 2026 · NCT05585164Understanding the Role of Doulas in Supporting People With PMADs
RecruitingHealthy volunteers welcome
Ages 18 and older · Women · Updated Aug 14, 2026 · NCT05763537Informing Implementation of a Circadian-Focused Intervention for Postpartum Depression
Recruiting
Ages 18 and older · Women · Updated Aug 14, 2026 · NCT07766161Parents and Babies Pilot
Recruiting
Ages 18 and older · Women · Updated Aug 6, 2026 · NCT07607613Implementation of a Clinical Decision Support Tool for Postpartum Depression
RecruitingHealthy volunteers welcome
Ages 18 and older · Women · Updated Jul 30, 2026 · NCT06818734NICU Utilization of Remote Voice Technology to Improve mateRnal Experience (NURTURE)
RecruitingHealthy volunteers welcome
Ages 18 and older · Women · Updated Jun 17, 2026 · NCT07214597Accelerated iTBS for Post Partum Depression
Recruiting
Ages 18 to 50 · Women · Updated May 22, 2026 · NCT03417960The ROSE Scale-up Study: Informing a Decision About ROSE as Universal PPD Prevention
RecruitingHealthy volunteers welcome
Ages 18 and older · Women · Updated May 18, 2026 · NCT05700760The Mom and Infant Outcomes (MOMI) Study
Recruiting
All ages · Women · Updated May 14, 2026 · NCT06277661ROSE in Sunset Park
RecruitingHealthy volunteers welcome
Ages 18 to 100 · Women · Updated Mar 30, 2026 · NCT04940585Clinical Validation of a Predictive Test for Postpartum Depression
RecruitingObservational studyHealthy volunteers welcome
Ages 18 and older · Women · Updated Dec 3, 2025 · NCT06831968A Study of a Test for Postpartum Depression at Home
RecruitingObservational studyHealthy volunteers welcome
Ages 18 and older · Women · Updated Nov 28, 2025 · NCT07186309Postpartum Care in the NICU (PeliCaN) Transitions
Recruiting
Ages 16 and older · Women · Updated Oct 14, 2025 · NCT06521398HeartGPS: A Study Exploring the Effects of a Psychological Intervention for Parents and Their Babies After Prenatal Cardiac Diagnosis
Recruiting
Ages 18 and older · All sexes · Updated Jul 20, 2025 · NCT06175104Improving Maternal Sleep and Mental Health
RecruitingHealthy volunteers welcome
Ages 18 to 45 · Women · Updated Feb 10, 2025 · NCT06544941The Dream Team: Testing Implementation of a Sleep Intervention for Perinatal Women Delivered by Direct Care Workers
RecruitingHealthy volunteers welcome
Ages 18 to 99 · All sexes · Updated Dec 27, 2024 · NCT06737055Maternal Mental Health Access - MaMa
RecruitingHealthy volunteers welcome
Ages 18 and older · Women · Updated Dec 6, 2024 · NCT06049433From ClinicalTrials.gov, data retrieved Oct 5, 2026. Each study sets its own eligibility; the study team decides who can join.