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Amyloidosis clinical trials recruiting in the U.S.

29 studies for Amyloidosis are recruiting participants at sites across the United States.

Amyloidosis is a rare condition that can affect different organs of the body. Find out about amyloidosis treatment and symptoms.

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Recently updated studies

A Study of JNJ-79635322 in Participants With Relapsed or Refractory Multiple Myeloma or Previously Treated Amyloid Light-chain (AL) Amyloidosis

RecruitingPhase 1
Ages 18 and older ยท All sexes ยท Updated Sep 28, 2026 ยท NCT05652335

Non-interventional Study of Patients With Transthyretin (ATTR) Amyloidosis

RecruitingObservational study
Ages 18 to 130 ยท All sexes ยท Updated Sep 23, 2026 ยท NCT06465810

TRITON-CM: A Study to Evaluate Nucresiran in Patients With Transthyretin Amyloidosis With Cardiomyopathy

RecruitingPhase 3
Ages 18 to 85 ยท All sexes ยท Updated Sep 16, 2026 ยท NCT07052903

DemonsTTRate: A Global, Observational, Multicenter, Long-term Study of Patients With ATTR-CM in a Real-World Setting

RecruitingObservational study
Ages 18 and older ยท All sexes ยท Updated Sep 9, 2026 ยท NCT07358078

ConTTRibute: A Global Observational Study of Patients With Transthyretin (TTR)-Mediated Amyloidosis (ATTR Amyloidosis)

RecruitingObservational study
All ages ยท All sexes ยท Updated Sep 8, 2026 ยท NCT04561518

Patisiran-Lipid Nanoparticle (LNP) Pregnancy Surveillance Program

RecruitingObservational study
All ages ยท Women ยท Updated Sep 8, 2026 ยท NCT05040373

Prevalence and Prediction of ATTR in Ambulatory Patients With HFpEF

Recruiting
Ages 65 and older ยท All sexes ยท Updated Sep 1, 2026 ยท NCT05577819

Subclinical Transthyretin Cardiac Amyloidosis in V122I TTR Carriers

RecruitingObservational study
Ages 30 to 80 ยท All sexes ยท Updated Aug 31, 2026 ยท NCT05489549

Phase 1/2a Study of Belantamab Mafodotin in Relapsed or Refractory AL Amyloidosis

RecruitingPhase 1/2
Ages 18 and older ยท All sexes ยท Updated Aug 19, 2026 ยท NCT05145816

Acoramidis Transthyretin Amyloidosis Prevention Trial in the Young (ACT-EARLY) Study in Asymptomatic Carriers of a Pathogenic TTR Variant

RecruitingPhase 3
Ages 18 to 75 ยท All sexes ยท Updated Aug 4, 2026 ยท NCT06563895

Cardiac Magnetic Resonance and Echocardiography Study With Acoramidis

RecruitingPhase 4
Ages 18 to 80 ยท All sexes ยท Updated Jul 29, 2026 ยท NCT07695701

A Phase 1 Study of 99mTc-p5+14 in Healthy Volunteers and Patients With AL or ATTR Systemic Amyloidosis

RecruitingPhase 1Healthy volunteers welcome
Ages 18 and older ยท All sexes ยท Updated Jul 24, 2026 ยท NCT05951816

[64Cu]FBP8 PET for Early Detection of Intracardiac Thrombus in Amyloid Cardiomyopathy

RecruitingPhase 3
Ages 18 and older ยท All sexes ยท Updated Jul 21, 2026 ยท NCT07560306

A Phase 1b/2 Study of CAR T Cell Therapy Targeting CD19 and BCMA in Participants With Relapsed or Refractory AL Amyloidosis.

RecruitingPhase 1/2
Ages 18 and older ยท All sexes ยท Updated Jul 2, 2026 ยท NCT07081646

Dietary Reporting In The Amyloidoses

Recruiting
Ages 18 and older ยท All sexes ยท Updated Jun 26, 2026 ยท NCT05738005

Characterizing Iodine-124 Evuzumitide (AT-01) in Systemic Amyloidosis

RecruitingPhase 2
Ages 40 to 90 ยท All sexes ยท Updated Apr 13, 2026 ยท NCT05758493

MAGNITUDE: A Phase 3 Study of NTLA-2001 in Participants With Transthyretin Amyloidosis With Cardiomyopathy (ATTR-CM)

RecruitingPhase 3
Ages 18 to 90 ยท All sexes ยท Updated Mar 27, 2026 ยท NCT06128629

Minimal Residual Disease Response-adapted Deferral of Transplant in Dysproteinemia (MILESTONE)

RecruitingPhase 2
Ages 18 and older ยท All sexes ยท Updated Dec 31, 2025 ยท NCT04991103

A Study Of Myocardial Stiffness In Amyloidosis With Magnetic Resonance Elastography

RecruitingObservational study
Ages 20 and older ยท All sexes ยท Updated Dec 26, 2025 ยท NCT07216469

From ClinicalTrials.gov, data retrieved Oct 1, 2026. Each study sets its own eligibility; the study team decides who can join.