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Anal Cancer clinical trials recruiting in the U.S.
24 studies for Anal Cancer are recruiting participants at sites across the United States.
Anal cancer is rare. HPV is one of the most common causes. Find out more about anal cancer symptoms, diagnosis, and treatment.
Cities with the most studies
- Houston, TX6 studies
- Los Angeles, CA5 studies
- Edison, NJ4 studies
- Nashville, TN4 studies
- New York City, NY4 studies
- Chicago, IL3 studies
- Atlanta, GA3 studies
- Cleveland, OH3 studies
- San Francisco, CA3 studies
By state
- California9 studies
- Colorado3 studies
- Florida5 studies
- Georgia3 studies
- Illinois5 studies
- Indiana3 studies
- Maryland4 studies
- Massachusetts3 studies
- Michigan3 studies
- New Jersey4 studies
- New York7 studies
- North Carolina5 studies
- Ohio7 studies
- Pennsylvania4 studies
- Tennessee4 studies
- Texas8 studies
- Wisconsin4 studies
Recently updated studies
DESTINY-PANTUMOUR04
RecruitingObservational study
Ages 18 to 130 · All sexes · Updated Sep 25, 2026 · NCT07124000EQUITY GI: A Prospective Study to Enhance Quality, Inclusivity, and Trial Participation in Black Patients With Gastrointestinal Cancer.
Recruiting
Ages 18 and older · All sexes · Updated Sep 15, 2026 · NCT06263088A Study Evaluating the Safety, Efficacy, and Pharmacokinetics (PK) of EVOLVE104 in Participants With Advanced Urothelial and Squamous Cell Carcinomas
RecruitingPhase 1
Ages 18 and older · All sexes · Updated Sep 15, 2026 · NCT07217171A Study of IDP-001 in Advanced or Metastatic Solid Tumors
RecruitingPhase 1/2
Ages 18 and older · All sexes · Updated Sep 3, 2026 · NCT07602842Ovarian-Sparing Adaptive Radiotherapy in Young Adult Women
RecruitingObservational study
Ages 18 to 50 · Women · Updated Sep 2, 2026 · NCT06904365Radiation Therapy for the Treatment of Metastatic Gastrointestinal Cancers
Recruiting
Ages 18 and older · All sexes · Updated Aug 14, 2026 · NCT04221893ctHPVDNA Response-Adapted Chemoradiation +/- Retifanlimab Treatment in Locally-Advanced Anal Cancer
RecruitingPhase 2
Ages 18 and older · All sexes · Updated Aug 14, 2026 · NCT07425054SMP-3124LP in Adults With Advanced Solid Tumors
RecruitingPhase 1/2
Ages 18 and older · All sexes · Updated Aug 12, 2026 · NCT06526819Distance-Based Exercise to Preserve Function and Prevent Disability
Recruiting
Ages 18 and older · All sexes · Updated Aug 5, 2026 · NCT07059884A Phase 1 Study of PLN-101095 in Adults With Advanced or Metastatic Solid Tumors
RecruitingPhase 1
Ages 18 and older · All sexes · Updated Aug 3, 2026 · NCT06270706Study of Pembrolizumab, Carboplatin, Paclitaxel, and Radiation for the Treatment of Early-Stage Anal Cancer
RecruitingPhase 2
Ages 18 and older · All sexes · Updated Jul 28, 2026 · NCT06493019Integrated Cancer Repository for Cancer Research
RecruitingObservational studyHealthy volunteers welcome
Ages 19 to 110 · All sexes · Updated Jun 29, 2026 · NCT02012699E7 TCR-T Cell Immunotherapy for Human Papillomavirus (HPV) Associated Cancers
RecruitingPhase 2
Ages 18 and older · All sexes · Updated Jun 12, 2026 · NCT05686226E7 T-cell Receptor (TCR) -T Cell Induction Therapy for Locoregionally Advanced HPV-associated Cancers
RecruitingPhase 1/2
Ages 18 and older · All sexes · Updated Jun 12, 2026 · NCT05639972MR-Adaptive Radiation Therapy for Anal Cancer With EScalated-Treatment in a Risk-Optimized Approach
RecruitingPhase 2
Ages 18 and older · All sexes · Updated Jun 10, 2026 · NCT06050707Collecting Blood and Tissue Sample Donations for Research for HIV/AIDS-Related Cancers
RecruitingObservational study
Ages 18 and older · All sexes · Updated Jun 1, 2026 · NCT05663502Self-sampling to Optimize Anal Lesion Outcomes
RecruitingHealthy volunteers welcome
Ages 35 and older · All sexes · Updated May 12, 2026 · NCT07192055Vaginal DHEA to Improve Vaginal Health After Radiation for Women With Gynecologic, Anal or Rectal Cancer
RecruitingPhase 2
Ages 50 and older · Women · Updated Apr 21, 2026 · NCT07407647Detecting HPV DNA in Anal and Cervical Cancers
RecruitingObservational study
Ages 18 and older · All sexes · Updated Mar 4, 2026 · NCT04857528Virtual Reality for GI Cancer Pain to Improve Patient Reported Outcomes
Recruiting
Ages 18 to 99 · All sexes · Updated Feb 20, 2026 · NCT04907643Adaptive Radiation in Anal Cancer
Recruiting
Ages 18 and older · All sexes · Updated Feb 3, 2026 · NCT05838391Ganglion Impar Neurolysis for the Improvement of Radiation-Induced Pain During Localized Anal or Perianal Skin Cancer Treatment
Recruiting
Ages 18 and older · All sexes · Updated Jan 30, 2026 · NCT07112690A Study to Evaluate TROP2 ADC LCB84 Single Agent and in Combination With an Anti-PD-1 Ab in Advanced Solid Tumors
RecruitingPhase 1/2
Ages 18 and older · All sexes · Updated Sep 24, 2025 · NCT05941507Screening Women With Prior HPV for Anal Neoplasia
Recruiting
Ages 35 and older · Women · Updated Aug 22, 2025 · NCT05217940From ClinicalTrials.gov, data retrieved Sep 29, 2026. Each study sets its own eligibility; the study team decides who can join.