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Appendiceal Cancer clinical trials recruiting in the U.S.
16 studies for Appendiceal Cancer are recruiting participants at sites across the United States.
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Recently updated studies
Pressurized Intraperitoneal Aerosolized Chemotherapy With Mitomycin for the Treatment of Unresectable Appendix or Colorectal Cancer With Peritoneal Metastases, The IMPACT Trial
RecruitingPhase 3
Ages 18 and older · All sexes · Updated Sep 25, 2026 · NCT07271355Study of Elironrasib and Daraxonrasib as Monotherapies and Combination Therapy in Participants With Advanced KRAS G12C Mutant Solid Tumors
RecruitingPhase 1/2
Ages 18 and older · All sexes · Updated Sep 22, 2026 · NCT06128551Safety and Efficacy of PIPAC Using Single Agent Mitomycin in Solid Tumors
RecruitingPhase 1
Ages 18 and older · All sexes · Updated Sep 16, 2026 · NCT07487168EQUITY GI: A Prospective Study to Enhance Quality, Inclusivity, and Trial Participation in Black Patients With Gastrointestinal Cancer.
Recruiting
Ages 18 and older · All sexes · Updated Sep 15, 2026 · NCT06263088Studying the PAGODA Algorithm for Chemotherapy Dose Changes to Prevent Unplanned Treatment Delays
RecruitingHealthy volunteers welcome
Ages 18 and older · All sexes · Updated Sep 2, 2026 · NCT07283939PIPAC for the Treatment of Peritoneal Carcinomatosis in Patients With Ovarian, Uterine, Appendiceal, Colorectal, or Gastric Cancer
RecruitingPhase 1
Ages 18 and older · All sexes · Updated Aug 26, 2026 · NCT04329494Individual Response to Hyperthermic Intraperitoneal Chemotherapy (HIPEC) Treatment of Peritoneal Carcinomatosis From Peritoneal Mesothelioma or Atypical Mesothelial Proliferation or From Ovarian, Colorectal, or Appendiceal Histologies
RecruitingPhase 1
Ages 18 to 120 · All sexes · Updated Aug 25, 2026 · NCT04847063The Appendix Cancer PMP Research Foundation Natural History Study/Patient Registry
RecruitingObservational study
All ages · All sexes · Updated Aug 17, 2026 · NCT07769346A Feasibility Study of Mass-Based Response Drug Screening to Guide Personalized Hyperthermic Intraperitoneal Chemotherapy for High-Grade Appendiceal and Colorectal Adenocarcinoma With Peritoneal Metastasis
Recruiting
Ages 18 to 81 · All sexes · Updated Jul 21, 2026 · NCT07291180Locally ablatIVe thErapy for oLigo-progressive gastrOintestiNal maliGnancies (LIVELONG)
Recruiting
Ages 18 and older · All sexes · Updated Jul 2, 2026 · NCT06101277Molecular Profiling for Risk Stratification in Appendiceal Cancer
RecruitingObservational study
Ages 18 and older · All sexes · Updated Jun 29, 2026 · NCT07587268Individualized Dose Escalation of 5-FU for Gastrointestinal Cancer
Recruiting
Ages 18 and older · All sexes · Updated Jun 22, 2026 · NCT05780684Flat Dose vs. Weight-based IP Chemotherapy for CRS/HIPEC
RecruitingPhase 2
Ages 18 and older · All sexes · Updated Apr 1, 2026 · NCT04779554Virtual Reality for GI Cancer Pain to Improve Patient Reported Outcomes
Recruiting
Ages 18 to 99 · All sexes · Updated Feb 20, 2026 · NCT04907643Intraoperative Imaging of Gastrointestinal Malignancies Using Pafolacianine (CYTALUX™)
RecruitingPhase 4
Ages 18 and older · All sexes · Updated Sep 15, 2025 · NCT07124351Genetics of Appendix Cancer Study
RecruitingObservational studyHealthy volunteers welcome
Ages 18 and older · All sexes · Updated Apr 18, 2025 · NCT05734430From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.