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Arrhythmia clinical trials recruiting in the U.S.

40 studies for Arrhythmia are recruiting participants at sites across the United States.

Arrhythmia, also called irregular heartbeat comes in different types. The most common is atrial fibrillation. Read about symptoms and treatment.

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Recently updated studies

A Study to Investigate the Efficacy, Safety, Tolerability and Pharmacokinetics of PKN605 in Participants With Atrial Fibrillation

RecruitingPhase 2
Ages 18 and older · All sexes · Updated Sep 28, 2026 · NCT07217067

BIOTRONIK Investigation of the LivIQ Leadless Pacemaker System

Recruiting
Ages 18 and older · All sexes · Updated Sep 24, 2026 · NCT07118358

Biospecimen Repository for Cardiac Arrhythmias at the Cleveland Clinic

RecruitingObservational studyHealthy volunteers welcome
Ages 18 and older · All sexes · Updated Sep 14, 2026 · NCT00921986

Early Screening and Treatment of Heart Complication in Sickle Cell Disease

RecruitingPhase 2
Ages 18 and older · All sexes · Updated Sep 9, 2026 · NCT07023666

Surveillance Trial of the Apple Watch in Reliable Burden Assessment in Unseen Recurrence of Surgically Treated AF

RecruitingObservational study
Ages 22 and older · All sexes · Updated Sep 8, 2026 · NCT07122947

Exercise Activity Intervention With Sensor-Based Engagement in Patients With Atrial Fibrillation

Recruiting
Ages 18 and older · All sexes · Updated Aug 24, 2026 · NCT06938412

Pharmacokinetics, Pharmacodynamics, and Safety Profile of Understudied Drugs Administered to Children Per Standard of Care (POPS)

RecruitingObservational studyHealthy volunteers welcome
Ages 0 to 20 · All sexes · Updated Aug 21, 2026 · NCT04278404

NOrthwestern Tempus AI-enaBLed Electrocardiography (NOTABLE) Trial

RecruitingHealthy volunteers welcome
Ages 40 and older · All sexes · Updated Aug 20, 2026 · NCT06511505

Product Performance Report: Evaluate Long-term Reliability & Performance of Medtronic Marketed Cardiac Therapy Products

RecruitingObservational study
All ages · All sexes · Updated Aug 20, 2026 · NCT00271180

Observational Study of Cardiac Arrhythmias During Treatment With BTK Inhibitors or Venetoclax

RecruitingObservational study
Ages 18 to 110 · All sexes · Updated Aug 7, 2026 · NCT05724121

Evaluation of A Clinical Diagnostic Test for CRDS

Recruiting
All ages · All sexes · Updated Jul 22, 2026 · NCT06188689

Safety and Efficacy of the Sentinel Cerebral Protection Device in Atrial Fibrillation Ablation

Recruiting
Ages 18 and older · All sexes · Updated Jul 21, 2026 · NCT04685317

A Usability Study of a Multi-channel ECG Monitoring Device

RecruitingHealthy volunteers welcome
Ages 18 and older · All sexes · Updated Jul 21, 2026 · NCT07388355

HeartBeam ECG Registry

RecruitingObservational studyHealthy volunteers welcome
Ages 18 and older · All sexes · Updated Jul 20, 2026 · NCT07501299

The PIVATAL Study -Study of Ventricular Arrhythmia (VTA) Ablation in Left Ventricular Assist Device (LVAD) Patients

RecruitingPhase 4
Ages 18 and older · All sexes · Updated Jul 14, 2026 · NCT05034432

A Phase 2 Study of CRD-4730 in CPVT

RecruitingPhase 2
Ages 18 to 99 · All sexes · Updated Jul 9, 2026 · NCT06658899

ViewFlex X ICE First-in-Human Study

RecruitingObservational study
Ages 18 and older · All sexes · Updated Jun 2, 2026 · NCT06772493

AI-Enabled Direct-from-ECG Ejection Fraction (EF) Severity Assessment Using COR ECG Wearable Monitor

RecruitingObservational studyHealthy volunteers welcome
Ages 18 and older · All sexes · Updated Jun 1, 2026 · NCT06699056

Aveir DR Real-World Evidence Post-Approval Study

RecruitingObservational study
Ages 18 and older · All sexes · Updated May 20, 2026 · NCT05935007

Tulane iPredict, Prevent Study to Evaluate the Progression of Atrial Myopathy.

RecruitingObservational study
Ages 18 to 79 · All sexes · Updated May 19, 2026 · NCT04703166

Developing a Digital Aid to Improve ICD Decisions

Recruiting
Ages 60 and older · All sexes · Updated Apr 27, 2026 · NCT07084142

Mayo AVC Registry and Biobank

RecruitingObservational studyHealthy volunteers welcome
All ages · All sexes · Updated Apr 27, 2026 · NCT03049254

From ClinicalTrials.gov, data retrieved Sep 29, 2026. Each study sets its own eligibility; the study team decides who can join.