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Autoimmune Diseases clinical trials recruiting in the U.S.

76 studies for Autoimmune Diseases are recruiting participants at sites across the United States.

Autoimmune diseases are where your immune system attacks healthy cells in your body by mistake. Learn about the symptoms, tests, and treatments.

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Recently updated studies

Environmental Risk Factors for the Anti-synthetase Syndrome

RecruitingObservational studyHealthy volunteers welcome
Ages 2 to 100 · All sexes · Updated Sep 28, 2026 · NCT01276470

Pilot Trial of Allogeneic Blood or Marrow Transplantation for Primary Immunodeficiencies

RecruitingPhase 2Healthy volunteers welcome
Ages 4 to 75 · All sexes · Updated Sep 28, 2026 · NCT02579967

Natural History of Bronchiectasis

RecruitingObservational studyHealthy volunteers welcome
Ages 5 to 100 · All sexes · Updated Sep 28, 2026 · NCT00943514

NIAID Centralized Sequencing Protocol

RecruitingObservational studyHealthy volunteers welcome
1 Day – 100 Years · All sexes · Updated Sep 28, 2026 · NCT03206099

Secukinumab Open Label Roll-over Extension Protocol

RecruitingPhase 4
Ages 6 to 100 · All sexes · Updated Sep 28, 2026 · NCT04638647

Safety of Belimumab in People With Idiopathic CD4 Lymphopenia and Autoantibodies (Phoebe)

RecruitingPhase 1
Ages 18 to 70 · All sexes · Updated Sep 28, 2026 · NCT04097561

Allogeneic Hematopoietic Stem Cell Transplant for Patients With Inborn Errors of Immunity

RecruitingPhase 2
Ages 4 to 69 · All sexes · Updated Sep 28, 2026 · NCT04339777

A Study of JADE101 in Participants With Immunoglobulin A Nephropathy

RecruitingPhase 2
Ages 18 to 60 · All sexes · Updated Sep 25, 2026 · NCT07541287

Screening Protocol for Genetic Diseases of Lymphocyte Homeostasis and Programmed Cell Death

RecruitingObservational study
1 Month – 100 Years · All sexes · Updated Sep 24, 2026 · NCT00246857

Study of Autoimmune Lymphoproliferative Syndrome (ALPS)

RecruitingObservational study
Up to age 99 · All sexes · Updated Sep 24, 2026 · NCT00001350

Testing an Immunotherapy Anti-cancer Drug, Nivolumab, for Advanced Cancers in Patients With Autoimmune Disorders, AIM-NIVO

RecruitingPhase 1
Ages 18 and older · All sexes · Updated Sep 23, 2026 · NCT03816345

Rituximab Plus Cyclosporine in Idiopathic Membranous Nephropathy

RecruitingPhase 2
Ages 18 to 90 · All sexes · Updated Sep 22, 2026 · NCT00977977

A Study of Mezagitamab in Adults With Chronic Primary Immune Thrombocytopenia

RecruitingPhase 3
Ages 18 and older · All sexes · Updated Sep 18, 2026 · NCT06722235

A Phase IIa Study of ICG318 CAR-T in Refractory Systemic Lupus Erythematosus With or Without Lupus Nephritis

RecruitingPhase 2
Ages 16 to 70 · All sexes · Updated Sep 17, 2026 · NCT07328581

Ublituximab in Autoantibody Positive Immune Mediated Necrotizing Myopathy

RecruitingPhase 2
Ages 18 and older · All sexes · Updated Sep 17, 2026 · NCT07103746

Daratumumab in Primary Antiphospholipid Syndrome

RecruitingPhase 1/2
Ages 18 to 65 · All sexes · Updated Sep 16, 2026 · NCT05671757

METabolic MODulation to Enhance Insulin Sensitivity and Mitochondrial Function in Type 1 Diabetes (MetMod-T1D)

RecruitingPhase 2
Ages 18 to 69 · All sexes · Updated Sep 15, 2026 · NCT07699380

A Study Investigating Intravenous Human Normal Immunoglobulin 10% in Adults With Chronic Immune Thrombocytopenia (ITP)

RecruitingPhase 3
Ages 18 to 70 · All sexes · Updated Sep 11, 2026 · NCT07059000

A Follow-up Study of Mezagitamab in Adults With Chronic Primary Immune Thrombocytopenia

RecruitingPhase 3
Ages 18 and older · All sexes · Updated Sep 9, 2026 · NCT06948318

PS-002 for the Treatment of IgA Nephropathy in Adults

RecruitingPhase 1/2
Ages 18 and older · All sexes · Updated Sep 9, 2026 · NCT07182227

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.