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B-Cell Leukemia clinical trials recruiting in the U.S.

17 studies for B-Cell Leukemia are recruiting participants at sites across the United States.

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Recently updated studies

Acalabrutinib Monotherapy vs Investigator's Choice of Treatment in Patients With CL Leukaemia and Heart Failure

RecruitingPhase 4
Ages 18 to 130 · All sexes · Updated Sep 24, 2026 · NCT06651970

Efficacy and Safety of Nemtabrutinib (MK-1026) in Participants With Hematologic Malignancies (MK-1026-003)

RecruitingPhase 2
Ages 18 and older · All sexes · Updated Sep 24, 2026 · NCT04728893

Chimeric Antigen Receptor Treatment Targeting CD70 (SEVENTY)

RecruitingPhase 1
Up to age 75 · All sexes · Updated Sep 16, 2026 · NCT06345027

A Study of AZD0486 Monotherapy or in Combination With Other Anti-Cancer Agents for Mature B-Cell Malignancies

RecruitingPhase 1/2
Ages 18 and older · All sexes · Updated Sep 8, 2026 · NCT06564038

Trivalent CAR-T Cell in Acute B-Lineage Leukemia (TRICAR-ALL)

RecruitingPhase 1
12 Months – 25 Years · All sexes · Updated Sep 4, 2026 · NCT05010564

Caloric Restriction and Activity to Reduce Chemoresistance in B-ALL

RecruitingPhase 2
Ages 7 to 25 · All sexes · Updated Aug 19, 2026 · NCT05082519

ROCKET-CLL Global Phase 3 Study: Rocbrutinib vs Pirtobrutinib in cBTKi-Pretreated R/R CLL/SLL

RecruitingPhase 3
Ages 18 and older · All sexes · Updated Aug 11, 2026 · NCT07342478

A Study of Lonitoclax (ZE50-0134) in Relapsed or Refractory B-cell Malignancies

RecruitingPhase 1
Ages 18 and older · All sexes · Updated Jul 31, 2026 · NCT06708897

The OPAL Study: AVM0703 for Treatment of Lymphoid Malignancies

RecruitingPhase 1/2
Ages 12 to 95 · All sexes · Updated Apr 15, 2026 · NCT04329728

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.