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Bipolar Disorder clinical trials recruiting in the U.S.

57 studies for Bipolar Disorder are recruiting participants at sites across the United States.

Bipolar disorder is a mood disorder that can cause intense mood swings. It's also called manic depression. Learn about the types, symptoms, treatment, and more.

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Recently updated studies

Examining Neurobiological Mechanisms Underlying the Therapeutic Effect of the Ketogenic Diet in Bipolar Disorder (BD)

RecruitingHealthy volunteers welcome
Ages 18 to 40 · All sexes · Updated Nov 12, 2026 · NCT06081426

Time Restricted Eating (TRE) in Bipolar Disorder

Recruiting
Ages 18 to 65 · All sexes · Updated Nov 10, 2026 · NCT07211217

Natural History of Depression, Bipolar Disorder and Suicide Risk

RecruitingObservational study
Ages 18 to 120 · All sexes · Updated Nov 9, 2026 · NCT06462196

Safety and Feasibility of DBS for Bipolar Depression

Recruiting
Ages 22 to 70 · All sexes · Updated Nov 6, 2026 · NCT07745374

A Study of Brenipatide in Adult Participants With Bipolar Disorder (RENEW-Bipolar-1)

RecruitingPhase 2
Ages 18 to 75 · All sexes · Updated Nov 4, 2026 · NCT07286175

Multicenter Study of Lumateperone for the Treatment of Bipolar Depression in Pediatric Patients

RecruitingPhase 3
Ages 10 to 17 · All sexes · Updated Nov 3, 2026 · NCT06372964

Attentional Biases, Reward Sensitivity, and Cognitive Control in Adults With Bipolar Disorder

RecruitingObservational studyHealthy volunteers welcome
Ages 18 and older · All sexes · Updated Oct 9, 2026 · NCT03829787

NIMH Rhythms and Blues Study: A Prospective Natural History Study of Motor Activity, Mood States, and Bipolar Disorder

RecruitingObservational studyHealthy volunteers welcome
Ages 8 to 70 · All sexes · Updated Oct 7, 2026 · NCT05669703

Evaluation of Patients With Mood and Anxiety Disorders and Healthy Volunteers

RecruitingObservational studyHealthy volunteers welcome
Ages 3 to 99 · All sexes · Updated Oct 2, 2026 · NCT00024635

Neuromodulation of Mood Switch Circuitry in Bipolar Disorder

RecruitingPhase 4
Ages 18 to 70 · All sexes · Updated Sep 23, 2026 · NCT07680153

Enhancing Veteran-Clinical Collaboration in VA PRRCs

Recruiting
Ages 18 and older · All sexes · Updated Aug 19, 2026 · NCT06898879

Ketogenic Intervention for Bipolar Depression

Recruiting
Ages 18 to 50 · All sexes · Updated Aug 17, 2026 · NCT07121894

Ketogenic and Nutritional Interventions for First Episode Bipolar Disorder

Recruiting
Ages 18 to 45 · All sexes · Updated Aug 17, 2026 · NCT06221852

Acceptability & Safety of Two Sequential Doses of Psilocybin in Bipolar Disorder II Depression and Suicidality

RecruitingPhase 2
Ages 25 to 70 · All sexes · Updated Aug 12, 2026 · NCT06706232

Determining Efficacy and Safety of BXCL501 in Agitation Associated With Pediatric Schizophrenia and Bipolar Disorder

RecruitingPhase 1
Ages 10 to 17 · All sexes · Updated Aug 11, 2026 · NCT05025605

Healthy Lifestyles for Bipolar Disorder

Recruiting
Ages 18 to 65 · All sexes · Updated Aug 4, 2026 · NCT06188754

Intermittent Theta Burst Stimulation (iTBS) for Emotion Regulation in Bipolar Disorder

Recruiting
Ages 24 to 65 · All sexes · Updated Jul 16, 2026 · NCT06274567

Exercise and Olanzapine-samidorphan

RecruitingPhase 4
Ages 18 to 65 · All sexes · Updated Jul 13, 2026 · NCT06740890

From ClinicalTrials.gov, data retrieved Nov 15, 2026. Each study sets its own eligibility; the study team decides who can join.