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Bipolar Disorder clinical trials recruiting in the U.S.

59 studies for Bipolar Disorder are recruiting participants at sites across the United States.

Bipolar disorder is a mood disorder that can cause intense mood swings. It's also called manic depression. Learn about the types, symptoms, treatment, and more.

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Recently updated studies

Evaluation of Patients With Mood and Anxiety Disorders and Healthy Volunteers

RecruitingObservational studyHealthy volunteers welcome
Ages 3 to 99 · All sexes · Updated Sep 28, 2026 · NCT00024635

Multicenter Study of Lumateperone for the Treatment of Bipolar Depression in Pediatric Patients

RecruitingPhase 3
Ages 10 to 17 · All sexes · Updated Sep 25, 2026 · NCT06372964

Neuromodulation of Mood Switch Circuitry in Bipolar Disorder

RecruitingPhase 4
Ages 18 to 70 · All sexes · Updated Sep 23, 2026 · NCT07680153

Safety and Feasibility of DBS for Bipolar Depression

Recruiting
Ages 22 to 70 · All sexes · Updated Sep 22, 2026 · NCT07745374

A Study of Brenipatide in Adult Participants With Bipolar Disorder (RENEW-Bipolar-1)

RecruitingPhase 2
Ages 18 to 75 · All sexes · Updated Sep 22, 2026 · NCT07286175

Enhancing Veteran-Clinical Collaboration in VA PRRCs

Recruiting
Ages 18 and older · All sexes · Updated Aug 19, 2026 · NCT06898879

Ketogenic and Nutritional Interventions for First Episode Bipolar Disorder

Recruiting
Ages 18 to 45 · All sexes · Updated Aug 17, 2026 · NCT06221852

Ketogenic Intervention for Bipolar Depression

Recruiting
Ages 18 to 50 · All sexes · Updated Aug 17, 2026 · NCT07121894

Natural History of Depression, Bipolar Disorder and Suicide Risk

RecruitingObservational study
Ages 18 to 120 · All sexes · Updated Aug 14, 2026 · NCT06462196

NIMH Rhythms and Blues Study: A Prospective Natural History Study of Motor Activity, Mood States, and Bipolar Disorder

RecruitingObservational studyHealthy volunteers welcome
Ages 8 to 70 · All sexes · Updated Aug 13, 2026 · NCT05669703

Low Amplitude Pulse Seizure Therapy Versus Standard Ultra-Brief Right Unilateral Electroconvulsive Therapy

RecruitingPhase 2/3
Ages 18 to 90 · All sexes · Updated Aug 12, 2026 · NCT06529029

Acceptability & Safety of Two Sequential Doses of Psilocybin in Bipolar Disorder II Depression and Suicidality

RecruitingPhase 2
Ages 25 to 70 · All sexes · Updated Aug 12, 2026 · NCT06706232

Determining Efficacy and Safety of BXCL501 in Agitation Associated With Pediatric Schizophrenia and Bipolar Disorder

RecruitingPhase 1
Ages 10 to 17 · All sexes · Updated Aug 11, 2026 · NCT05025605

Healthy Lifestyles for Bipolar Disorder

Recruiting
Ages 18 to 65 · All sexes · Updated Aug 4, 2026 · NCT06188754

Intermittent Theta Burst Stimulation (iTBS) for Emotion Regulation in Bipolar Disorder

Recruiting
Ages 24 to 65 · All sexes · Updated Jul 16, 2026 · NCT06274567

Exercise and Olanzapine-samidorphan

RecruitingPhase 4
Ages 18 to 65 · All sexes · Updated Jul 13, 2026 · NCT06740890

A Novel Peer-Delivered Recovery-Focused Suicide Prevention Intervention for Veterans With Serious Mental Illness

Recruiting
Ages 18 and older · All sexes · Updated Jul 10, 2026 · NCT05537376

RNA Editing as a Biomarker of Antidepressant Response in Unipolar and Bipolar Depression (EDIT-ANDRE)

RecruitingPhase 4
Ages 18 to 65 · All sexes · Updated Jun 22, 2026 · NCT07266545

From ClinicalTrials.gov, data retrieved Sep 29, 2026. Each study sets its own eligibility; the study team decides who can join.