Home › Bipolar Disorder
Bipolar Disorder clinical trials recruiting in the U.S.
57 studies for Bipolar Disorder are recruiting participants at sites across the United States.
Bipolar disorder is a mood disorder that can cause intense mood swings. It's also called manic depression. Learn about the types, symptoms, treatment, and more.
Cities with the most studies
- Houston, TX9 studies
- New York City, NY7 studies
- Boston, MA7 studies
- Little Rock, AR5 studies
- Hialeah, FL5 studies
- Atlanta, GA5 studies
- Austin, TX5 studies
- Cambridge, MA5 studies
- Cincinnati, OH4 studies
- Bellevue, WA4 studies
- Anaheim, CA4 studies
- Rochester, MN4 studies
- Orange, CA4 studies
- Chicago, IL4 studies
- San Diego, CA4 studies
- Philadelphia, PA4 studies
- San Bernardino, CA3 studies
- Everett, WA3 studies
- Richmond, VA3 studies
- Sugar Land, TX3 studies
- Naperville, IL3 studies
- West Palm Beach, FL3 studies
- Miami, FL3 studies
- O'Fallon, MO3 studies
- Savannah, GA3 studies
- Parma, OH3 studies
- Washington, DC3 studies
- Orlando, FL3 studies
- Richardson, TX3 studies
By state
- Arkansas5 studies
- California16 studies
- Connecticut3 studies
- Florida7 studies
- Georgia8 studies
- Illinois6 studies
- Iowa3 studies
- Maryland5 studies
- Massachusetts10 studies
- Michigan3 studies
- Minnesota6 studies
- Missouri4 studies
- Nebraska3 studies
- New York9 studies
- Ohio6 studies
- Oklahoma5 studies
- Pennsylvania6 studies
- Texas15 studies
- Virginia4 studies
- Washington4 studies
Recently updated studies
Examining Neurobiological Mechanisms Underlying the Therapeutic Effect of the Ketogenic Diet in Bipolar Disorder (BD)
RecruitingHealthy volunteers welcome
Ages 18 to 40 · All sexes · Updated Nov 12, 2026 · NCT06081426Time Restricted Eating (TRE) in Bipolar Disorder
Recruiting
Ages 18 to 65 · All sexes · Updated Nov 10, 2026 · NCT07211217Natural History of Depression, Bipolar Disorder and Suicide Risk
RecruitingObservational study
Ages 18 to 120 · All sexes · Updated Nov 9, 2026 · NCT06462196Safety and Feasibility of DBS for Bipolar Depression
Recruiting
Ages 22 to 70 · All sexes · Updated Nov 6, 2026 · NCT07745374A Study of Brenipatide in Adult Participants With Bipolar Disorder (RENEW-Bipolar-1)
RecruitingPhase 2
Ages 18 to 75 · All sexes · Updated Nov 4, 2026 · NCT07286175Safety and Tolerability Trial of Lumateperone in Pediatric Patients With Schizophrenia, Bipolar Disorder or Autism Spectrum Disorder
RecruitingPhase 3
Ages 5 to 17 · All sexes · Updated Nov 3, 2026 · NCT06229210Multicenter Study of Lumateperone for the Treatment of Bipolar Depression in Pediatric Patients
RecruitingPhase 3
Ages 10 to 17 · All sexes · Updated Nov 3, 2026 · NCT06372964A Study to Evaluate the Efficacy and Safety of Adjunctive KarXT for the Treatment of Mania, With or Without Mixed Features, in Participants With Bipolar-I Disorder Taking Lithium, Valproate, or Lamotrigine
RecruitingPhase 3
Ages 18 to 65 · All sexes · Updated Nov 3, 2026 · NCT07140913Attentional Biases, Reward Sensitivity, and Cognitive Control in Adults With Bipolar Disorder
RecruitingObservational studyHealthy volunteers welcome
Ages 18 and older · All sexes · Updated Oct 9, 2026 · NCT03829787NIMH Rhythms and Blues Study: A Prospective Natural History Study of Motor Activity, Mood States, and Bipolar Disorder
RecruitingObservational studyHealthy volunteers welcome
Ages 8 to 70 · All sexes · Updated Oct 7, 2026 · NCT05669703Acceptability and Feasibility of Work-Oriented Social-Cognitive Skills Training for Veterans With Serious Mental Illness
Recruiting
Ages 18 and older · All sexes · Updated Oct 2, 2026 · NCT05491538Evaluation of Patients With Mood and Anxiety Disorders and Healthy Volunteers
RecruitingObservational studyHealthy volunteers welcome
Ages 3 to 99 · All sexes · Updated Oct 2, 2026 · NCT00024635Neuromodulation of Mood Switch Circuitry in Bipolar Disorder
RecruitingPhase 4
Ages 18 to 70 · All sexes · Updated Sep 23, 2026 · NCT07680153A Study to Evaluate the Effectiveness of Valbenazine in Adult Participants With Tardive Dyskinesia (TD) Who Remain Symptomatic While Receiving or After Stopping a Vesicular Monoamine Transporter 2 (VMAT2) Inhibitor
RecruitingPhase 4
Ages 18 and older · All sexes · Updated Sep 18, 2026 · NCT07105111A Study to Assess Adverse Events and How Oral ABBV-932 Moves Through the Body When Given With Oral Itraconazole in Adult Participants With Bipolar Disorder
RecruitingPhase 1
Ages 18 to 65 · All sexes · Updated Sep 16, 2026 · NCT07071532The Effects of Lumateperone on Obesity and Physiologic Aging and Their Association With Antidepressant Response in Bipolar Depression
RecruitingPhase 4
Ages 18 to 65 · All sexes · Updated Sep 11, 2026 · NCT07699445Enhancing Veteran-Clinical Collaboration in VA PRRCs
Recruiting
Ages 18 and older · All sexes · Updated Aug 19, 2026 · NCT06898879Ketogenic Intervention for Bipolar Depression
Recruiting
Ages 18 to 50 · All sexes · Updated Aug 17, 2026 · NCT07121894Ketogenic and Nutritional Interventions for First Episode Bipolar Disorder
Recruiting
Ages 18 to 45 · All sexes · Updated Aug 17, 2026 · NCT06221852A Study to Assess Adverse Events and Change in Disease Activity of Oral Icalcaprant in Adult Participants With Bipolar I or II Disorder
RecruitingPhase 2
Ages 18 to 65 · All sexes · Updated Aug 14, 2026 · NCT06696755Acceptability & Safety of Two Sequential Doses of Psilocybin in Bipolar Disorder II Depression and Suicidality
RecruitingPhase 2
Ages 25 to 70 · All sexes · Updated Aug 12, 2026 · NCT06706232Determining Efficacy and Safety of BXCL501 in Agitation Associated With Pediatric Schizophrenia and Bipolar Disorder
RecruitingPhase 1
Ages 10 to 17 · All sexes · Updated Aug 11, 2026 · NCT05025605Healthy Lifestyles for Bipolar Disorder
Recruiting
Ages 18 to 65 · All sexes · Updated Aug 4, 2026 · NCT06188754Intermittent Theta Burst Stimulation (iTBS) for Emotion Regulation in Bipolar Disorder
Recruiting
Ages 24 to 65 · All sexes · Updated Jul 16, 2026 · NCT06274567Exercise and Olanzapine-samidorphan
RecruitingPhase 4
Ages 18 to 65 · All sexes · Updated Jul 13, 2026 · NCT06740890From ClinicalTrials.gov, data retrieved Nov 15, 2026. Each study sets its own eligibility; the study team decides who can join.