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Bone Cancer clinical trials recruiting in the U.S.
19 studies for Bone Cancer are recruiting participants at sites across the United States.
Bone cancer comes in three types: Osteosarcoma, Chondrosarcoma, and Ewing's sarcoma. Learn how bone cancer is diagnosed and treated.
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Recently updated studies
A Phase 2 Trial of Zanzalintinib in Advanced/Metastatic Bone Sarcomas (ZAMBONE)
RecruitingPhase 2
Ages 18 and older · All sexes · Updated Sep 25, 2026 · NCT07193550Financial Toxicity in Patients With Resected Soft Tissue and Bone Sarcomas
RecruitingObservational study
All ages · All sexes · Updated Sep 11, 2026 · NCT07215611Bridging Adolescent and Young Adult Sarcoma Survivors With Personalized Oncology Exercise Service (AYA-ONE): A Pilot Intervention
Recruiting
Ages 15 to 39 · All sexes · Updated Aug 26, 2026 · NCT07662239Pulmonary Suffusion in Controlling Minimal Residual Disease in Patients With Sarcoma or Colorectal Metastases
RecruitingPhase 1/2
Ages 18 and older · All sexes · Updated Aug 21, 2026 · NCT03965234Integration of Adaptive Proton Therapy in Pediatric Solid Tumors and Hodgkin's Lymphoma
Recruiting
All ages · All sexes · Updated Aug 21, 2026 · NCT07514819Evaluation of Tumor Resection Guided by Intraoperative Indocyanine Green Dye Fluorescence Angiography in Patients With Sarcoma
RecruitingObservational study
Ages 18 and older · All sexes · Updated Aug 4, 2026 · NCT06409013U.S. Prospective Evaluation of EPIONE Device for Percutaneous MSK Procedures
Recruiting
Ages 22 and older · All sexes · Updated Jul 20, 2026 · NCT07325578Study of Aerosol Gemcitabine in Patients With Solid Tumors and Pulmonary Metastases
RecruitingPhase 1
Ages 12 to 50 · All sexes · Updated Jul 15, 2026 · NCT03093909XL092 (Zanzalintinib) for the Treatment of Patients With Metastatic or Unresectable Leiomyosarcoma, Bone Sarcoma or Translocation-associated Soft Tissue Sarcoma
RecruitingPhase 2
Ages 18 and older · All sexes · Updated Jun 18, 2026 · NCT06571734Palliative Dose Escalated Radiation for Painful Non-Spine Bone Metastases and Painful Non-Bone Metas
RecruitingPhase 2
Ages 18 and older · All sexes · Updated Jun 2, 2026 · NCT05419518Iscador® P (Mistletoe) Immunotherapy for Recurrent Resectable Osteogenic Sarcoma
RecruitingPhase 2
Ages 8 to 30 · All sexes · Updated May 22, 2026 · NCT05726383Study Assessing the Effects of Early Psychiatric Referral on Mental Health and Quality of Life in People With Sarcoma
Recruiting
Ages 18 and older · All sexes · Updated May 15, 2026 · NCT06129903Samarium Optimized for Long-lasting Analgesia in Cancerous End-stage Bone Pain
RecruitingPhase 1
Ages 18 and older · All sexes · Updated May 14, 2026 · NCT07197645Mg OSTEOCRETE Post-Treatment Outcomes
RecruitingObservational study
Ages 18 and older · All sexes · Updated Apr 22, 2026 · NCT06720142Assessment of Healing and Function After Reconstruction Surgery for Bone Sarcomas
RecruitingObservational study
Ages 4 and older · All sexes · Updated Apr 17, 2026 · NCT03442465Comparing Carbon Ion Therapy, Surgery, and Proton Therapy for Management of Pelvic Sarcomas Involving the Bone
RecruitingObservational study
Ages 15 and older · All sexes · Updated Mar 13, 2026 · NCT05033288An Electronic Health Record (EHR)-Based Comprehensive Bone and Soft Tissue Tumor Registry
RecruitingObservational study
Ages 18 and older · All sexes · Updated Feb 11, 2026 · NCT02677961Genetic Analysis of Pheochromocytomas, Paragangliomas and Associated Conditions
RecruitingObservational studyHealthy volunteers welcome
All ages · All sexes · Updated Oct 15, 2025 · NCT03160274Definitive Radiation for High-Risk Spine Metastases
RecruitingPhase 2
Ages 18 and older · All sexes · Updated May 14, 2025 · NCT06165419From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.