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Cancer (all types) clinical trials in South Dakota
14 studies for Cancer (all types) are looking for participants at sites in South Dakota.
Cities in South Dakota
Testing the Addition of Herceptin Hylecta or Phesgo to the Usual Chemotherapy for HER2 Positive Endometrial Serous Carcinoma or Carcinosarcoma
- Avera Cancer Institute-Aberdeen, Aberdeen
- Sanford Cancer Center Oncology Clinic, Sioux Falls
- Avera Cancer Institute, Sioux Falls
- and 1 more
RecruitingPhase 3
Ages 18 and older · Women · Updated Sep 29, 2026 · NCT05256225A Study of Ifinatamab Deruxtecan in Pediatric Participants With Relapsed or Refractory Solid Tumors (MK-9999-01D/LIGHTBEAM-U01)
- Sanford Children's Hospital ( Site 4015), Sioux Falls
RecruitingPhase 1/2
1 Month – 17 Years · All sexes · Updated Sep 25, 2026 · NCT07630974TAPUR: Testing the Use of Food and Drug Administration (FDA) Approved Drugs That Target a Specific Abnormality in a Tumor Gene in People With Advanced Stage Cancer
- Sanford Cancer Center Oncology Clinic and Pharmacy, Sioux Falls
RecruitingPhase 2
Ages 12 and older · All sexes · Updated Sep 22, 2026 · NCT02693535A Study of Patritumab Deruxtecan in Pediatric Participants With Relapsed or Refractory Solid Tumors (MK-9999-01C/LIGHTBEAM-U01)
- Sanford Children's Hospital ( Site 3015), Sioux Falls
RecruitingPhase 1/2
1 Month – 17 Years · All sexes · Updated Sep 17, 2026 · NCT06941272Connect for Cancer Prevention Study (Connect)
- Sanford Health, Sioux Falls
RecruitingObservational studyHealthy volunteers welcome
Ages 30 to 70 · All sexes · Updated Sep 17, 2026 · NCT04609072A Phase IIIb Study to Evaluate Camizestrant Plus Ribociclib in ER-positive, HER2-negative Advanced Breast Cancer
- Research Site, Sioux Falls
RecruitingPhase 3
Ages 18 to 130 · All sexes · Updated Sep 8, 2026 · NCT07647328A Longitudinal Multi-Omic Biomarker Profiling Study of Patients With Head & Neck Squamous Cell Carcinoma (HNSCC)
- Sanford Sioux Falls, Sioux Falls
RecruitingObservational study
Ages 18 and older · All sexes · Updated Sep 3, 2026 · NCT06163534KEYMAKER-U01 Substudy 01J: A Study of Pembrolizumab Plus MK-1084 in Participants With Non-Small Cell Lung Cancer (NSCLC) With Kirsten Rat Sarcoma Viral Oncogene Homolog (KRAS) G12C Mutations (MK-3475-01J/KEYMAKER-U01J)
- Sanford Cancer Center Oncology Clinic ( Site 0038), Sioux Falls
RecruitingPhase 2
Ages 18 and older · All sexes · Updated Sep 2, 2026 · NCT07252739Project: Every Child for Younger Patients With Cancer
- Sanford USD Medical Center - Sioux Falls, Sioux Falls
RecruitingObservational study
Up to age 25 · All sexes · Updated Aug 25, 2026 · NCT02402244Testing Olaparib for One or Two Years, With or Without Bevacizumab, to Treat Ovarian Cancer
- Avera Cancer Institute-Aberdeen, Aberdeen
- Avera Cancer Institute - Mitchell, Mitchell
- Avera Cancer Institute at Pierre, Pierre
- and 4 more
RecruitingPhase 3
Ages 18 and older · All sexes · Updated Aug 7, 2026 · NCT06580314Study of Trastuzumab Deruxtecan Versus Standard of Care Chemotherapy for HER2-Expressing (IHC 3+/2+) Endometrial Cancer
- Avera Medical Group Gynecologic Oncology Sioux Falls, Sioux Falls
- Texas Oncology, P.A. - Tyler, Sioux Falls
RecruitingPhase 3
Ages 18 and older · Women · Updated Jul 28, 2026 · NCT07022483I-SPY TRIAL: Neoadjuvant and Personalized Adaptive Novel Agents to Treat Breast Cancer
- Sanford Clinical Research, Sioux Falls
RecruitingPhase 2
Ages 18 and older · All sexes · Updated May 6, 2026 · NCT01042379Avera Cancer Sequencing and Analytics Protocol (ASAP)
- Avera Cancer Institute - Aberdeen, Aberdeen
- Avera Cancer Institute - Mitchell, Mitchell
- Avera Cancer Institute - Pierre, Pierre
- and 2 more
RecruitingObservational study
Ages 18 and older · All sexes · Updated Mar 27, 2026 · NCT05142033Melanoma Margins Trial-II: 1cm v 2cm Wide Surgical Excision Margins for AJCC Stage II Primary Cutaneous Melanoma
- Sanford Cancer Center Oncology Clinic, Sioux Falls
- Sanford USD Medical Center - Sioux Falls, Sioux Falls
Recruiting
Ages 18 and older · All sexes · Updated Nov 27, 2024 · NCT03860883From ClinicalTrials.gov, data retrieved Oct 1, 2026. Each study sets its own eligibility; the study team decides who can join.