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Complex Regional Pain Syndrome clinical trials recruiting in the U.S.
12 studies for Complex Regional Pain Syndrome are recruiting participants at sites across the United States.
Complex regional pain syndrome, CRPS or Reflex Sympathetic Dystrophy, RSD are chronic pain conditions. They cause intense pain and can spread.
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Recently updated studies
CRPS-RISE Outcomes Registry
RecruitingObservational study
Ages 18 and older · All sexes · Updated Sep 29, 2026 · NCT07811362Evaluation of IV AMBTX-01 (Neridronate) for Treatment of CRPS Type 1 (CRPS-RISE)
RecruitingPhase 3
Ages 18 and older · All sexes · Updated Sep 10, 2026 · NCT07210515Effects of Non-invasive Brain Stimulation on Pain Avoidance Behavior in Chronic Pain Patients
Recruiting
Ages 18 and older · All sexes · Updated Aug 28, 2026 · NCT07791966Closed-Loop Deep Brain Stimulation for Refractory Chronic Pain
Recruiting
Ages 22 to 80 · All sexes · Updated Jul 31, 2026 · NCT04144972TMS for Complex Regional Pain Syndrome
Recruiting
Ages 18 to 70 · All sexes · Updated Jun 23, 2026 · NCT03137472Supraspinal Processing of Sensory Aspects of Pain
RecruitingHealthy volunteers welcome
Ages 10 to 17 · All sexes · Updated Jun 5, 2026 · NCT05814497Intermittent Dosing of Dorsal Root Ganglion Stimulation as an Alternate Paradigm to Continuous Low-Frequency Therapy
Recruiting
Ages 18 to 90 · All sexes · Updated Jan 21, 2026 · NCT04909138Infrared Images for Spinal Cord Stimulation in Complex Regional Pain Syndrome Patients
RecruitingObservational study
Ages 18 to 85 · All sexes · Updated Nov 26, 2025 · NCT05777889Role of the Gut Microbiome in Complex Regional Pain Syndrome
RecruitingObservational studyHealthy volunteers welcome
Ages 18 and older · All sexes · Updated Nov 5, 2025 · NCT03612193Closed Loop Spinal Cord Stimulation for Complex Regional Pain Syndrome
Recruiting
Ages 18 and older · All sexes · Updated Nov 3, 2025 · NCT06421350Low-Dose Naltrexone for the Treatment of Complex Regional Pain Syndrome
Recruiting
Ages 18 to 70 · All sexes · Updated May 29, 2025 · NCT02502162The Effects and Mechanisms of a High CBD Cannabis Extract (BRC-002) for the Treatment of Pain and Health in Complex Regional Pain Syndrome
RecruitingPhase 1
Ages 21 to 75 · All sexes · Updated Jun 7, 2024 · NCT06393101From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.