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Cushing's Syndrome clinical trials recruiting in the U.S.
12 studies for Cushing's Syndrome are recruiting participants at sites across the United States.
Cushing's Syndrome (Hypercortisolism) is a rare hormonal disorder caused by over exposure to the hormone, Cortisol. Lab tests can show if you have it.
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Recently updated studies
Evaluation of Adults With Endocrine and Metabolic-Related Conditions
RecruitingObservational studyHealthy volunteers welcome
Ages 18 to 100 · All sexes · Updated Sep 28, 2026 · NCT02830308Prospective Evaluation of 68Ga-DOTATATE PET/CT, Octreotide and F-DOPA PET Imaging in Ectopic Cushing Syndrome
RecruitingPhase 2
Ages 18 to 80 · All sexes · Updated Sep 28, 2026 · NCT02019706Metyrapone Study for Patients Diagnosed With Mild Autonomous Cortisol Secretion - MACS
RecruitingPhase 2
Ages 18 and older · All sexes · Updated Sep 25, 2026 · NCT07138274Evaluating the Functional Status of the Adrenal Glands With [68Ga]Ga-PentixaFor in Hyperaldosteronism and Hypercortisolism
RecruitingPhase 2
Ages 18 to 120 · All sexes · Updated Sep 23, 2026 · NCT06246357Recovery From Cushing Syndrome and Mild Autonomous Cortisol Secretion (MACS)
RecruitingObservational study
Ages 18 and older · All sexes · Updated Sep 18, 2026 · NCT04543253A Block-and-Replace Therapy With Osilodrostat and Concomitant Glucocorticoid Replacement
RecruitingObservational study
Ages 18 to 75 · All sexes · Updated Sep 9, 2026 · NCT06430528Trial Against INtractable Type 2 Diabetes (CAPTAIN-T2D)
RecruitingPhase 2
Ages 18 and older · All sexes · Updated Sep 9, 2026 · NCT07296484Desmopressin Stimulation Test Performance in ACTH-Dependent Cushing Syndrome
RecruitingPhase 2Healthy volunteers welcome
Ages 18 to 70 · All sexes · Updated Aug 31, 2026 · NCT06635629IMPACT-MACS: Adrenalectomy vs Semaglutide for Metabolic Outcomes in Mild Autonomous Cortisol Secretion
Recruiting
Ages 18 and older · All sexes · Updated Mar 27, 2026 · NCT07361874Pharmacokinetic (PK), Pharmacodynamic (PD) and Tolerability of Osilodrostat in Pediatric Patients With Cushing's Syndrome
RecruitingPhase 2
Ages 2 to 17 · All sexes · Updated Mar 27, 2026 · NCT03708900Impact of 1 mg Osilodrostat Therapy on Mild Autonomous Cortisol Secretion (MACS)
RecruitingPhase 2
Ages 18 and older · All sexes · Updated Feb 11, 2026 · NCT07104812Collecting Information About Treatment Results for Patients With Cushing's Syndrome
RecruitingObservational study
Ages 14 and older · All sexes · Updated Oct 23, 2025 · NCT03364803From ClinicalTrials.gov, data retrieved Oct 2, 2026. Each study sets its own eligibility; the study team decides who can join.