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Disorders of Excessive Somnolence clinical trials recruiting in the U.S.

16 studies for Disorders of Excessive Somnolence are recruiting participants at sites across the United States.

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Recently updated studies

A Phase 3 Efficacy and Safety Study of HBS-301 in Participants With Idiopathic Hypersomnia (IH)

RecruitingPhase 3
Ages 18 and older · All sexes · Updated Nov 13, 2026 · NCT07500090

Rare Disease Patient Registry & Natural History Study - Coordination of Rare Diseases at Sanford

RecruitingObservational study
All ages · All sexes · Updated Oct 28, 2026 · NCT01793168

Clinical Assessment of Response in the Treatment of Depression With Daytime Sleepiness Using Solriamfetol

RecruitingPhase 3
Ages 18 to 65 · All sexes · Updated Oct 13, 2026 · NCT07484217

A Long-Term Study of ALKS 2680 in Subjects With Narcolepsy and Idiopathic Hypersomnia

RecruitingPhase 2/3
Ages 18 to 70 · All sexes · Updated Oct 9, 2026 · NCT06767683

A Study to Evaluate the Efficacy and Safety of ALKS 2680 in Adults With Narcolepsy Type 1

RecruitingPhase 3
Ages 18 to 70 · All sexes · Updated Oct 7, 2026 · NCT07455383

A Study to Evaluate the Efficacy and Safety of ALKS 2680 in Adults With Narcolepsy Type 2

RecruitingPhase 3
Ages 18 to 70 · All sexes · Updated Oct 7, 2026 · NCT07502443

A Phase 3 Study to Evaluate the Efficacy and Safety of Samelisant in Patients With Narcolepsy (AWAKE)

RecruitingPhase 3
Ages 18 and older · All sexes · Updated Sep 3, 2026 · NCT07540364

A Study of Pitolisant in Patients With Prader-Willi Syndrome

RecruitingPhase 3
Ages 6 and older · All sexes · Updated Aug 25, 2026 · NCT06366464

Studying Solriamfetol Modulation of TAAR-1, Dopamine, and Norepinephrine in Shift Work Disorder (SUSTAIN)

RecruitingPhase 3
Ages 18 to 65 · All sexes · Updated Jul 24, 2026 · NCT06568367

Solriamfetol for the Treatment of Multiple Sclerosis Fatigue

RecruitingPhase 2
Ages 18 to 60 · All sexes · Updated Jun 9, 2026 · NCT06170970

A Long-term Extension Study of ORX750 in Participants With Narcolepsy and Idiopathic Hypersomnia

RecruitingPhase 2
Ages 18 to 65 · All sexes · Updated Apr 16, 2026 · NCT07096674

A Study of ORX142 in Healthy Adult Subjects, Including Subjects 18 to 80 Years of Age

RecruitingPhase 1Healthy volunteers welcome
Ages 18 to 80 · All sexes · Updated Dec 24, 2025 · NCT07082829

From ClinicalTrials.gov, data retrieved Nov 15, 2026. Each study sets its own eligibility; the study team decides who can join.