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Esophageal Adenocarcinoma clinical trials recruiting in the U.S.
47 studies for Esophageal Adenocarcinoma are recruiting participants at sites across the United States.
Cities with the most studies
- New York City, NY18 studies
- Boston, MA13 studies
- Houston, TX12 studies
- Arlington, VA11 studies
- Nashville, TN11 studies
- Durham, NC10 studies
- Baldwin Park, CA9 studies
- St. Louis, MO9 studies
- Jacksonville, FL9 studies
- Queens, NY9 studies
- Los Angeles, CA9 studies
- Rochester, MN9 studies
- Seattle, WA8 studies
- Dallas, TX8 studies
- Pittsburgh, PA8 studies
- Philadelphia, PA8 studies
- Chicago, IL8 studies
- Orange, CA7 studies
- Ann Arbor, MI7 studies
- Aurora, CO6 studies
- Minneapolis, MN6 studies
- Washington, DC6 studies
- Portland, OR6 studies
- Cleveland, OH6 studies
- Evanston, IL6 studies
- Indianapolis, IN6 studies
- San Antonio, TX5 studies
- Denver, CO5 studies
- New Haven, CT5 studies
- Charleston, SC5 studies
- Greenburgh, NY5 studies
- Rochester, NY5 studies
- Sioux Falls, SD5 studies
- Kansas City, MO5 studies
- Newport Beach, CA4 studies
- Scottsdale, AZ4 studies
- Salt Lake City, UT4 studies
- Atlanta, GA4 studies
- Las Vegas, NV4 studies
- Oklahoma City, OK4 studies
By state
- Alaska3 studies
- Arizona10 studies
- Arkansas4 studies
- California22 studies
- Colorado11 studies
- Connecticut7 studies
- Delaware3 studies
- District of Columbia4 studies
- Florida15 studies
- Georgia5 studies
- Illinois11 studies
- Indiana6 studies
- Iowa5 studies
- Kansas5 studies
- Louisiana3 studies
- Maryland6 studies
- Massachusetts13 studies
- Michigan9 studies
- Minnesota14 studies
- Missouri11 studies
- Nebraska4 studies
- Nevada5 studies
- New Jersey9 studies
- New York20 studies
- North Carolina12 studies
- Ohio12 studies
- Oklahoma4 studies
- Oregon6 studies
- Pennsylvania15 studies
- South Carolina6 studies
- South Dakota5 studies
- Tennessee13 studies
- Texas19 studies
- Utah5 studies
- Virginia13 studies
- Washington9 studies
- Wisconsin7 studies
Recently updated studies
A Study to Evaluate the Safety and Efficacy of Pumitamig in Combination With Chemotherapy Versus Nivolumab in Combination With Chemotherapy in Participants With Previously Untreated Advanced or Metastatic Gastric, Gastroesophageal Junction, or Esophageal Adenocarcinoma (ROSETTA Gastric-204)
RecruitingPhase 2/3
Ages 18 and older · All sexes · Updated Sep 30, 2026 · NCT07221149Beamion BCGC-1: A Study to Find a Suitable Dose of Zongertinib Used Alone and in Combination With Other Treatments to Test Whether it Helps People With Different Types of HER2+ Cancer That Has Spread
RecruitingPhase 1/2
Ages 18 and older · All sexes · Updated Sep 30, 2026 · NCT06324357Adding Nivolumab to Usual Treatment for People With Advanced Stomach or Esophageal Cancer, PARAMUNE Trial
RecruitingPhase 2/3
Ages 18 and older · All sexes · Updated Sep 29, 2026 · NCT06203600Upfront Chemotherapy With Radiation Therapy (CRT) Followed by Chemotherapy in Localized Esophageal Adenocarcinoma
RecruitingPhase 2
Ages 18 and older · All sexes · Updated Sep 29, 2026 · NCT07603375Lucid Registry Study
RecruitingObservational study
All ages · All sexes · Updated Sep 28, 2026 · NCT05965999Symbiotic-GI-16: A Study to Learn About the Study Medicine Called PF-08634404 in Combination With Chemotherapy in Gastroesophageal Cancer
RecruitingPhase 2/3
Ages 18 and older · All sexes · Updated Sep 28, 2026 · NCT07392892A Study of IDE892 as Monotherapy and Combination in MTAP-deleted Advanced Solid Tumors
RecruitingPhase 1
Ages 18 and older · All sexes · Updated Sep 28, 2026 · NCT07277413Study of AZD5863 in Adult Participants With Advanced or Metastatic Solid Tumors
RecruitingPhase 1/2
Ages 18 and older · All sexes · Updated Sep 25, 2026 · NCT06005493Study of Denikitug (GS-1811) Given Alone or With Nivolumab or Chemotherapy in Adults With Metastatic Gastric, Gastroesophageal Junction (GEJ), and Esophageal Adenocarcinomas
RecruitingPhase 2
Ages 18 and older · All sexes · Updated Sep 21, 2026 · NCT07546812Multi-Site Detection of Barrett's Esophagus in Patients Without Chronic GERD Symptoms
RecruitingHealthy volunteers welcome
Ages 50 and older · All sexes · Updated Sep 15, 2026 · NCT06687603A Study of 2141-V11 in People With Esophageal, Gastric, or Gastroesophageal Junction Adenocarcinoma
RecruitingPhase 1/2
Ages 18 and older · All sexes · Updated Sep 14, 2026 · NCT07818018Itraconazole in Combination With Ablation for the Prevention of Esophageal Cancer in Patients With High-risk Barrett's Esophagus
RecruitingPhase 2
Ages 18 and older · All sexes · Updated Sep 14, 2026 · NCT06732388Surveillance vs. Endoscopic Therapy for Barrett's Esophagus With Low-grade Dysplasia
Recruiting
Ages 18 to 89 · All sexes · Updated Sep 11, 2026 · NCT05753748A Study of KK2269 in Adult Participants With Solid Tumors
RecruitingPhase 1
Ages 18 and older · All sexes · Updated Sep 10, 2026 · NCT06266299Sonesitatug Vedotin in Combination With Capecitabine With or Without Rilvegostomig in Participants With Advanced or Metastatic Gastric, Gastroesophageal Junction, or Esophageal Adenocarcinoma Expressing Claudin18.2
RecruitingPhase 3
Ages 18 and older · All sexes · Updated Sep 9, 2026 · NCT07431281Trial Comparing Standard of Care Therapy With and Without Sequential Cytoreductive Intervention for Patients With Metastatic Foregut Adenocarcinoma and Undetectable Circulating Tumor-Deoxyribose Nucleic Acid (ctDNA) Levels
RecruitingPhase 2
Ages 18 to 80 · All sexes · Updated Sep 8, 2026 · NCT07282912A Study to Learn About the Study Medicine Called PF-08046876 in People With Advanced Solid Tumors
RecruitingPhase 1
Ages 18 and older · All sexes · Updated Sep 4, 2026 · NCT07090499mFOLFIRINOX Versus mFOLFOX With or Without Nivolumab for the Treatment of Advanced, Unresectable, or Metastatic HER2 Negative Esophageal, Gastroesophageal Junction, and Gastric Adenocarcinoma
RecruitingPhase 3
Ages 18 and older · All sexes · Updated Sep 3, 2026 · NCT05677490A Phase 1 Study Evaluating DISP-10 in Participants With Advanced Gastrointestinal Cancers
RecruitingPhase 1
Ages 18 and older · All sexes · Updated Aug 27, 2026 · NCT07544589A Phase 1 Study of NRM-823 in Participants With Locally Advanced or Metastatic Refractory Solid Tumors
RecruitingPhase 1
Ages 18 and older · All sexes · Updated Aug 18, 2026 · NCT07182149Liquid Nitrogen Spray Cryotherapy Prior to Neoadjuvant Systemic Therapy in Esophageal Adenocarcinoma
RecruitingPhase 2
Ages 18 and older · All sexes · Updated Aug 18, 2026 · NCT07222657Radiation Therapy for the Treatment of Metastatic Gastrointestinal Cancers
Recruiting
Ages 18 and older · All sexes · Updated Aug 14, 2026 · NCT04221893Obeticholic Acid for Prevention in Barrett's Esophagus
RecruitingPhase 2
Ages 18 and older · All sexes · Updated Aug 11, 2026 · NCT04939051A Study to Evaluate the Efficacy and Safety of Ifinatamab Deruxtecan (I-DXd) in Subjects With Recurrent or Metastatic Solid Tumors (IDeate-PanTumor02)
RecruitingPhase 1/2
Ages 18 and older · All sexes · Updated Aug 5, 2026 · NCT06330064A Study of CHS-114 (Tagmokitug) in Combination With Toripalimab and/or Other Treatments in Participants With Advanced Solid Tumors
RecruitingPhase 1
Ages 18 and older · All sexes · Updated Jul 15, 2026 · NCT06657144From ClinicalTrials.gov, data retrieved Oct 1, 2026. Each study sets its own eligibility; the study team decides who can join.