Home › Esophageal Adenocarcinoma
Esophageal Adenocarcinoma clinical trials recruiting in the U.S.
45 studies for Esophageal Adenocarcinoma are recruiting participants at sites across the United States.
Cities with the most studies
- New York City, NY17 studies
- Boston, MA12 studies
- Houston, TX12 studies
- Nashville, TN11 studies
- Arlington, VA11 studies
- Durham, NC10 studies
- Los Angeles, CA9 studies
- Queens, NY9 studies
- St. Louis, MO8 studies
- Philadelphia, PA8 studies
- Rochester, MN8 studies
- Jacksonville, FL8 studies
- Baldwin Park, CA8 studies
- Chicago, IL8 studies
- Pittsburgh, PA8 studies
- Cleveland, OH7 studies
- Dallas, TX7 studies
- Ann Arbor, MI7 studies
- Seattle, WA7 studies
- Orange, CA7 studies
- Minneapolis, MN6 studies
- Washington, DC6 studies
- Portland, OR6 studies
- Evanston, IL6 studies
- Indianapolis, IN6 studies
- Aurora, CO6 studies
- New Haven, CT5 studies
- Denver, CO5 studies
- Charleston, SC5 studies
- San Antonio, TX5 studies
- Tampa, FL5 studies
- Salt Lake City, UT5 studies
- Greenburgh, NY5 studies
- Kansas City, MO5 studies
- Sioux Falls, SD5 studies
- San Francisco, CA5 studies
- Rochester, NY5 studies
- Oklahoma City, OK4 studies
- Irving, TX4 studies
- Bridgeport, CT4 studies
By state
- Alaska3 studies
- Arizona9 studies
- Arkansas4 studies
- California21 studies
- Colorado11 studies
- Connecticut7 studies
- Delaware3 studies
- District of Columbia4 studies
- Florida15 studies
- Georgia5 studies
- Illinois11 studies
- Indiana6 studies
- Iowa5 studies
- Kansas5 studies
- Louisiana3 studies
- Maryland6 studies
- Massachusetts12 studies
- Michigan9 studies
- Minnesota13 studies
- Missouri10 studies
- Nebraska4 studies
- Nevada4 studies
- New Jersey8 studies
- New York19 studies
- North Carolina12 studies
- Ohio13 studies
- Oklahoma4 studies
- Oregon6 studies
- Pennsylvania15 studies
- South Carolina6 studies
- South Dakota5 studies
- Tennessee13 studies
- Texas18 studies
- Utah6 studies
- Virginia13 studies
- Washington8 studies
- Wisconsin6 studies
Recently updated studies
Adding Nivolumab to Usual Treatment for People With Advanced Stomach or Esophageal Cancer, PARAMUNE Trial
RecruitingPhase 2/3
Ages 18 and older · All sexes · Updated Nov 12, 2026 · NCT06203600Obeticholic Acid for Prevention in Barrett's Esophagus
RecruitingPhase 2
Ages 18 and older · All sexes · Updated Nov 12, 2026 · NCT04939051A Study to Learn About the Study Medicine Called PF-08046876 in People With Advanced Solid Tumors
RecruitingPhase 1
Ages 18 and older · All sexes · Updated Nov 5, 2026 · NCT07090499Beamion BCGC-1: A Study to Find a Suitable Dose of Zongertinib Used Alone and in Combination With Other Treatments to Test Whether it Helps People With Different Types of HER2+ Cancer That Has Spread
RecruitingPhase 1/2
Ages 18 and older · All sexes · Updated Nov 5, 2026 · NCT06324357A Study to Evaluate the Safety and Efficacy of Pumitamig in Combination With Chemotherapy Versus Nivolumab in Combination With Chemotherapy in Participants With Previously Untreated Advanced or Metastatic Gastric, Gastroesophageal Junction, or Esophageal Adenocarcinoma (ROSETTA Gastric-204)
RecruitingPhase 2/3
Ages 18 and older · All sexes · Updated Nov 5, 2026 · NCT07221149Upfront Chemotherapy With Radiation Therapy (CRT) Followed by Chemotherapy in Localized Esophageal Adenocarcinoma
RecruitingPhase 2
Ages 18 and older · All sexes · Updated Nov 4, 2026 · NCT07603375mFOLFIRINOX Versus mFOLFOX With or Without Nivolumab for the Treatment of Advanced, Unresectable, or Metastatic HER2 Negative Esophageal, Gastroesophageal Junction, and Gastric Adenocarcinoma
RecruitingPhase 3
Ages 18 and older · All sexes · Updated Nov 3, 2026 · NCT05677490A Study to Evaluate the Efficacy and Safety of Ifinatamab Deruxtecan (I-DXd) in Subjects With Recurrent or Metastatic Solid Tumors (IDeate-PanTumor02)
RecruitingPhase 1/2
Ages 18 and older · All sexes · Updated Oct 26, 2026 · NCT06330064Propranolol With Chemotherapy or Chemoradiation for Esophageal Adenocarcinoma
RecruitingPhase 2
Ages 18 and older · All sexes · Updated Oct 22, 2026 · NCT04682158Sonesitatug Vedotin in Combination With Capecitabine With or Without Rilvegostomig in Participants With Advanced or Metastatic Gastric, Gastroesophageal Junction, or Esophageal Adenocarcinoma Expressing Claudin18.2
RecruitingPhase 3
Ages 18 and older · All sexes · Updated Oct 16, 2026 · NCT07431281A Study of Mesothelin-Targeted CAR T-Cell Therapy in People With Esophagogastric Cancer or Malignant Peritoneal Mesothelioma
RecruitingPhase 1
Ages 18 and older · All sexes · Updated Oct 15, 2026 · NCT06623396Symbiotic-GI-16: A Study to Learn About the Study Medicine Called PF-08634404 in Combination With Chemotherapy in Gastroesophageal Cancer
RecruitingPhase 2/3
Ages 18 and older · All sexes · Updated Oct 13, 2026 · NCT07392892A Phase II Trial to Evaluate the Effect of Itraconazole on Pathologic Complete Response Rates in Resectable Esophageal Cancer
RecruitingPhase 2
Ages 18 and older · All sexes · Updated Oct 9, 2026 · NCT05563766Chemotherapy With or Without Radiation or Surgery in Treating Participants With Oligometastatic Esophageal or Gastric Cancer
RecruitingPhase 2
Ages 18 to 79 · All sexes · Updated Oct 6, 2026 · NCT03161522Oral TGF-beta Receptor I Inhibitor Vactosertib in SOC Chemoradiotherapy for Esophageal Adenocarcinoma
RecruitingPhase 2
Ages 18 and older · All sexes · Updated Oct 5, 2026 · NCT06044311A Phase 1 Study Evaluating DISP-10 in Participants With Advanced Gastrointestinal Cancers
RecruitingPhase 1
Ages 18 and older · All sexes · Updated Oct 5, 2026 · NCT07544589A Study of IDE892 as Monotherapy and Combination in MTAP-deleted Advanced Solid Tumors
RecruitingPhase 1
Ages 18 and older · All sexes · Updated Sep 28, 2026 · NCT07277413Lucid Registry Study
RecruitingObservational study
All ages · All sexes · Updated Sep 28, 2026 · NCT05965999Study of AZD5863 in Adult Participants With Advanced or Metastatic Solid Tumors
RecruitingPhase 1/2
Ages 18 and older · All sexes · Updated Sep 25, 2026 · NCT06005493Multi-Site Detection of Barrett's Esophagus in Patients Without Chronic GERD Symptoms
RecruitingHealthy volunteers welcome
Ages 50 and older · All sexes · Updated Sep 15, 2026 · NCT06687603A Study of 2141-V11 in People With Esophageal, Gastric, or Gastroesophageal Junction Adenocarcinoma
RecruitingPhase 1/2
Ages 18 and older · All sexes · Updated Sep 14, 2026 · NCT07818018Itraconazole in Combination With Ablation for the Prevention of Esophageal Cancer in Patients With High-risk Barrett's Esophagus
RecruitingPhase 2
Ages 18 and older · All sexes · Updated Sep 14, 2026 · NCT06732388Surveillance vs. Endoscopic Therapy for Barrett's Esophagus With Low-grade Dysplasia
Recruiting
Ages 18 to 89 · All sexes · Updated Sep 11, 2026 · NCT05753748Trial Comparing Standard of Care Therapy With and Without Sequential Cytoreductive Intervention for Patients With Metastatic Foregut Adenocarcinoma and Undetectable Circulating Tumor-Deoxyribose Nucleic Acid (ctDNA) Levels
RecruitingPhase 2
Ages 18 to 80 · All sexes · Updated Sep 8, 2026 · NCT07282912A Phase 1 Study of NRM-823 in Participants With Locally Advanced or Metastatic Refractory Solid Tumors
RecruitingPhase 1
Ages 18 and older · All sexes · Updated Aug 18, 2026 · NCT07182149From ClinicalTrials.gov, data retrieved Nov 15, 2026. Each study sets its own eligibility; the study team decides who can join.