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Hepatitis B clinical trials recruiting in the U.S.
15 studies for Hepatitis B are recruiting participants at sites across the United States.
Hepatitis B virus is a contagious liver infection spread from person-to-person via blood or body fluids. Who is at risk for HBV? Read about it here.
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Recently updated studies
National Liver Cancer Screening Trial
RecruitingPhase 4
Ages 18 to 85 ยท All sexes ยท Updated Sep 25, 2026 ยท NCT06084234A Study to Assess the Safety, Tolerability, and Pharmacokinetics of GIGA-2339 in Participants With Chronic Hepatitis B Virus Infection
RecruitingPhase 1
Ages 18 and older ยท All sexes ยท Updated Sep 25, 2026 ยท NCT07024641Study of AHB-137 in Chronic Hepatitis B (CHB) Participants in North America and Europe Regions
RecruitingPhase 2
Ages 18 to 65 ยท All sexes ยท Updated Sep 24, 2026 ยท NCT07654283Evaluation of Patients With Liver Disease
RecruitingObservational studyHealthy volunteers welcome
Ages 2 to 100 ยท All sexes ยท Updated Sep 24, 2026 ยท NCT00001971Phase 1 Study to Evaluate Safety and Antiviral Activity of PBGENE-HBV in Adult Patients With Chronic Hepatitis B
RecruitingPhase 1
Ages 18 to 70 ยท All sexes ยท Updated Aug 24, 2026 ยท NCT06680232VIR-2218 and Peginterferon Alfa-2a for Chronic Hepatitis B
RecruitingPhase 2
Ages 18 to 65 ยท All sexes ยท Updated Aug 18, 2026 ยท NCT06092333Rapid HIV, Hep C, and Syphilis Screening in a Rural Street Medicine Clinic
RecruitingObservational studyHealthy volunteers welcome
Ages 18 and older ยท All sexes ยท Updated Aug 13, 2026 ยท NCT07317687Collection of Blood From Healthy Patients, Patients With Benign Disease and Patients With Cancer
RecruitingObservational study
Ages 18 and older ยท All sexes ยท Updated Jul 10, 2026 ยท NCT05181826Adaptability of an Undetectable = Untransmissible Model for HBV
RecruitingObservational studyHealthy volunteers welcome
Ages 18 to 65 ยท All sexes ยท Updated May 15, 2026 ยท NCT07449091HepB mAb19 in Individuals With Chronic Hepatitis B Infection
RecruitingPhase 1
Ages 18 to 70 ยท All sexes ยท Updated Feb 2, 2026 ยท NCT05856890TLR-9 Adjuvanted Vaccination for Chronic Hepatitis B
RecruitingPhase 1
Ages 18 and older ยท All sexes ยท Updated Oct 20, 2025 ยท NCT04843852Intrahepatic and Peripheral Responses to Imdusiran (AB-729) in Chronic Hepatitis B
RecruitingPhase 2
Ages 18 and older ยท All sexes ยท Updated Sep 11, 2025 ยท NCT06154278Blood Collection Biorepository for Liver Disease Research
RecruitingObservational studyHealthy volunteers welcome
Ages 7 and older ยท All sexes ยท Updated Aug 27, 2025 ยท NCT03025074Antiretroviral Pregnancy Registry (APR): Multi-sponsor Registry to Detect Any Major Teratogenic Effect Involving Any of the Registry Drugs When Administered to Pregnant People.
RecruitingObservational study
Ages 12 to 60 ยท Women ยท Updated Apr 1, 2025 ยท NCT00404989Comparison Between 2-dose Versus 3-dose Regimens of Heplisav B in Cirrhosis
RecruitingPhase 4
Ages 18 and older ยท All sexes ยท Updated Nov 19, 2024 ยท NCT04588077From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.