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Hepatitis B clinical trials recruiting in the U.S.

15 studies for Hepatitis B are recruiting participants at sites across the United States.

Hepatitis B virus is a contagious liver infection spread from person-to-person via blood or body fluids. Who is at risk for HBV? Read about it here.

Cities with the most studies

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Recently updated studies

National Liver Cancer Screening Trial

RecruitingPhase 4
Ages 18 to 85 ยท All sexes ยท Updated Sep 25, 2026 ยท NCT06084234

A Study to Assess the Safety, Tolerability, and Pharmacokinetics of GIGA-2339 in Participants With Chronic Hepatitis B Virus Infection

RecruitingPhase 1
Ages 18 and older ยท All sexes ยท Updated Sep 25, 2026 ยท NCT07024641

Study of AHB-137 in Chronic Hepatitis B (CHB) Participants in North America and Europe Regions

RecruitingPhase 2
Ages 18 to 65 ยท All sexes ยท Updated Sep 24, 2026 ยท NCT07654283

Evaluation of Patients With Liver Disease

RecruitingObservational studyHealthy volunteers welcome
Ages 2 to 100 ยท All sexes ยท Updated Sep 24, 2026 ยท NCT00001971

Phase 1 Study to Evaluate Safety and Antiviral Activity of PBGENE-HBV in Adult Patients With Chronic Hepatitis B

RecruitingPhase 1
Ages 18 to 70 ยท All sexes ยท Updated Aug 24, 2026 ยท NCT06680232

VIR-2218 and Peginterferon Alfa-2a for Chronic Hepatitis B

RecruitingPhase 2
Ages 18 to 65 ยท All sexes ยท Updated Aug 18, 2026 ยท NCT06092333

Rapid HIV, Hep C, and Syphilis Screening in a Rural Street Medicine Clinic

RecruitingObservational studyHealthy volunteers welcome
Ages 18 and older ยท All sexes ยท Updated Aug 13, 2026 ยท NCT07317687

Collection of Blood From Healthy Patients, Patients With Benign Disease and Patients With Cancer

RecruitingObservational study
Ages 18 and older ยท All sexes ยท Updated Jul 10, 2026 ยท NCT05181826

Adaptability of an Undetectable = Untransmissible Model for HBV

RecruitingObservational studyHealthy volunteers welcome
Ages 18 to 65 ยท All sexes ยท Updated May 15, 2026 ยท NCT07449091

HepB mAb19 in Individuals With Chronic Hepatitis B Infection

RecruitingPhase 1
Ages 18 to 70 ยท All sexes ยท Updated Feb 2, 2026 ยท NCT05856890

TLR-9 Adjuvanted Vaccination for Chronic Hepatitis B

RecruitingPhase 1
Ages 18 and older ยท All sexes ยท Updated Oct 20, 2025 ยท NCT04843852

Intrahepatic and Peripheral Responses to Imdusiran (AB-729) in Chronic Hepatitis B

RecruitingPhase 2
Ages 18 and older ยท All sexes ยท Updated Sep 11, 2025 ยท NCT06154278

Blood Collection Biorepository for Liver Disease Research

RecruitingObservational studyHealthy volunteers welcome
Ages 7 and older ยท All sexes ยท Updated Aug 27, 2025 ยท NCT03025074

Comparison Between 2-dose Versus 3-dose Regimens of Heplisav B in Cirrhosis

RecruitingPhase 4
Ages 18 and older ยท All sexes ยท Updated Nov 19, 2024 ยท NCT04588077

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.