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Lyme Disease clinical trials recruiting in the U.S.

11 studies for Lyme Disease are recruiting participants at sites across the United States.

Lyme disease is an infection you get from tick bites. The first symptom is usually a rash. Learn about Lyme disease symptoms and treatment.

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Recently updated studies

A Comprehensive Clinical, Microbiological and Immunological Assessment of Patients With Suspected Post Treatment Lyme Disease Syndrome and Selected Control Populations

RecruitingObservational studyHealthy volunteers welcome
Ages 13 to 99 ยท All sexes ยท Updated Sep 22, 2026 ยท NCT00001539

Human Immune Response to Ixodes Scapularis Tick Bites

RecruitingPhase 1/2Healthy volunteers welcome
Ages 18 to 99 ยท All sexes ยท Updated Sep 22, 2026 ยท NCT05036707

Evaluation, Treatment, and Follow-up of Patients With Lyme Disease

RecruitingObservational study
Ages 2 to 99 ยท All sexes ยท Updated Aug 7, 2026 ยท NCT00028080

Navigating Pregnancy and Parenthood With Lyme Disease

RecruitingObservational study
Ages 18 and older ยท Women ยท Updated Jun 17, 2026 ยท NCT06397794

Pregnancy and Early Neurodevelopmental Outcomes Following In Utero Lyme Disease Exposure

RecruitingObservational study
Ages 18 and older ยท All sexes ยท Updated Jun 16, 2026 ยท NCT06026969

A Study to Learn About the Safety, Tolerability, and Immunogenicity of a Fifth Dose of 6-Valent OspA-Based Lyme Disease Vaccine

RecruitingPhase 3Healthy volunteers welcome
Ages 7 and older ยท All sexes ยท Updated May 6, 2026 ยท NCT07500506

Transcranial Direct Current Stimulation for Post Treatment Lyme Disease

Recruiting
Ages 18 to 70 ยท All sexes ยท Updated May 6, 2026 ยท NCT06915324

taVNS for Persistent Symptoms From Lyme Disease

Recruiting
Ages 18 to 65 ยท All sexes ยท Updated May 6, 2026 ยท NCT05776251

Lumbrokinase for Adults With Long Covid, Post-treatment Lyme Disease Syndrome, and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome

RecruitingPhase 1/2
Ages 18 and older ยท All sexes ยท Updated Mar 13, 2026 ยท NCT06511050

Rheumatology Patient Registry and Biorepository

RecruitingObservational studyHealthy volunteers welcome
Ages 18 to 99 ยท All sexes ยท Updated Feb 13, 2026 ยท NCT04402086

Rare Disease Patient Registry & Natural History Study - Coordination of Rare Diseases at Sanford

RecruitingObservational study
All ages ยท All sexes ยท Updated May 29, 2025 ยท NCT01793168

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.