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Metabolic Disorders clinical trials recruiting in the U.S.

55 studies for Metabolic Disorders are recruiting participants at sites across the United States.

Your metabolism makes energy from the food you eat. A metabolic disorder disrupts this process. One example is diabetes. Learn more.

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Recently updated studies

Natural History of the Human Biological Response to Environmental Exposure and Injury

RecruitingObservational studyHealthy volunteers welcome
Ages 18 to 90 · All sexes · Updated Sep 28, 2026 · NCT04888923

A Study to Learn About the Study Medicine Called Berobenatide (PF-08653944) in People With Overweight or Obesity

RecruitingPhase 3
Ages 18 and older · All sexes · Updated Sep 28, 2026 · NCT07595549

Natural History, Physiology, Microbiome and Biochemistry Studies of Propionic Acidemia

RecruitingObservational studyHealthy volunteers welcome
1 Month – 100 Years · All sexes · Updated Sep 28, 2026 · NCT02890342

Characterization of Patients With Uncommon Presentations and/or Uncommon Diseases Associated With the Cardiovascular System

RecruitingObservational studyHealthy volunteers welcome
Ages 1 to 100 · All sexes · Updated Sep 22, 2026 · NCT01143454

A First-in-human Study of KK8123 in Adults With X-linked Hypophosphatemia

RecruitingPhase 1/2
Ages 18 to 65 · All sexes · Updated Sep 21, 2026 · NCT06525636

A Safety and Tolerability Trial Evaluating CTX310 in Participants With Refractory Dyslipidemias

RecruitingPhase 1
Ages 18 to 75 · All sexes · Updated Sep 18, 2026 · NCT07491172

A Study to Investigate the Relative Bioavailability and Safety of Different Oral Formulations of Elecoglipron in Healthy Participants

RecruitingPhase 1Healthy volunteers welcome
Ages 18 to 55 · All sexes · Updated Sep 16, 2026 · NCT07723833

Characterization of Dysmorphology in Subjects With Creatine Transporter Deficiency

RecruitingObservational study
Ages 2 to 40 · Men · Updated Sep 16, 2026 · NCT05600946

Use of Cysteamine in the Treatment of Cystinosis

RecruitingObservational study
1 Week – 115 Years · All sexes · Updated Sep 16, 2026 · NCT00359684

Campath/Fludarabine/Melphalan Transplant Conditioning for Non-Malignant Diseases

RecruitingPhase 1/2
Up to age 20 · All sexes · Updated Sep 16, 2026 · NCT00920972

METabolic MODulation to Enhance Insulin Sensitivity and Mitochondrial Function in Type 1 Diabetes (MetMod-T1D)

RecruitingPhase 2
Ages 18 to 69 · All sexes · Updated Sep 15, 2026 · NCT07699380

A Natural History Study of Metabolic Sizing in Health and Disease

RecruitingObservational studyHealthy volunteers welcome
Ages 2 to 99 · All sexes · Updated Sep 15, 2026 · NCT05398783

Clinical and Laboratory Study of Methylmalonic Acidemia

RecruitingObservational studyHealthy volunteers welcome
1 Month – 115 Years · All sexes · Updated Sep 10, 2026 · NCT00078078

Clinical and Basic Investigations Into Hermansky-Pudlak Syndrome

RecruitingObservational study
1 Month – 115 Years · All sexes · Updated Sep 9, 2026 · NCT00001456

Improving Coronary Vascular Health in Women

RecruitingPhase 2
Ages 45 to 75 · Women · Updated Sep 8, 2026 · NCT06843902

Impact of NMES and HPRO on Recovery After SAH- Pilot Study

Recruiting
Ages 18 and older · All sexes · Updated Sep 4, 2026 · NCT03201094

A Study Evaluating the Efficacy and Safety of Pegozafermin in Participants With MASH and Fibrosis (ENLIGHTEN-Fibrosis)

RecruitingPhase 3
Ages 18 to 80 · All sexes · Updated Sep 3, 2026 · NCT06318169

A Study to Evaluate the Efficacy and Safety of Pegozafermin in Participants With Compensated Cirrhosis Due to MASH

RecruitingPhase 3
Ages 18 to 75 · All sexes · Updated Sep 3, 2026 · NCT06419374

Long-term Follow-up (LTFU) Study of Participants in Any iECURE Protocol Using an Investigational Product (IP)

RecruitingObservational study
7 Months – 15 Months · All sexes · Updated Aug 31, 2026 · NCT06805695

Evaluation of Children With Endocrine and Metabolic-Related Conditions

RecruitingObservational study
3 Months – 100 Years · All sexes · Updated Aug 13, 2026 · NCT02769975

Blood Specimen Collection For Laboratory Assay Research

RecruitingObservational studyMentions payment for participants
Ages 18 and older · All sexes · Updated Aug 13, 2026 · NCT06046651

An Open-label Study to Investigate ECUR-506 in Male Babies Less Than 9 Months of Age With Neonatal Onset OTC Deficiency

RecruitingPhase 3
24 Hours – 7 Months · Men · Updated Aug 12, 2026 · NCT06255782

NAUTICAL: Effect of Natriuretic Peptide Augmentation on Cardiometabolic Health in Black Individuals

RecruitingPhase 2Healthy volunteers welcome
Ages 18 and older · All sexes · Updated Jul 28, 2026 · NCT04055428

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.