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Mitral Valve Insufficiency clinical trials recruiting in the U.S.

25 studies for Mitral Valve Insufficiency are recruiting participants at sites across the United States.

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Recently updated studies

TVMR With the INNOVALVE System Trial - Early Feasibility Study

Recruiting
Ages 18 and older · All sexes · Updated Sep 21, 2026 · NCT04919980

Use of Force Feedback Instruments With the da Vinci Surgical System, Model IS5000 for Mitral Valve Repair

Recruiting
Ages 22 and older · All sexes · Updated Sep 14, 2026 · NCT07655505

Cephea Early Feasibility Study

Recruiting
Ages 18 and older · All sexes · Updated Sep 11, 2026 · NCT05061004

Abbott Cephea Mitral Valve Disease Registry

RecruitingObservational study
Ages 18 and older · All sexes · Updated Sep 10, 2026 · NCT07069673

EFS of Posterior Leaflet Replacement to Reduce Mitral Regurgitation (United States)

Recruiting
Ages 21 and older · All sexes · Updated Sep 1, 2026 · NCT07517588

Reduction or Elimination of Mitral Regurgitation With the SATURN TMVR System (CASSINI-US)

Recruiting
Ages 18 and older · All sexes · Updated Aug 10, 2026 · NCT07130994

ATLAS (AltaValve) Pivotal Trial

Recruiting
Ages 18 and older · All sexes · Updated Aug 3, 2026 · NCT06465745

The CardioClip Study

Recruiting
Ages 18 to 90 · All sexes · Updated Jun 29, 2026 · NCT06241430

STS/ACC TVT Registry Mitral Module

RecruitingObservational studyHealthy volunteers welcome
Ages 1 and older · All sexes · Updated Jun 15, 2026 · NCT02245763

CHoice of OptImal transCatheter trEatment for Mitral Insufficiency Registry

RecruitingObservational study
Ages 18 and older · All sexes · Updated May 7, 2026 · NCT04688190

Transcatheter Mitral Valve Repair for Inotrope Dependent Cardiogenic Shock

Recruiting
Ages 18 and older · All sexes · Updated May 6, 2026 · NCT05298124

A Clinical Study of GeminiOne TEER System for the Treatment of Severe, Symptomatic MR.

Recruiting
Ages 18 and older · All sexes · Updated Apr 24, 2026 · NCT07086534

DELINEATE-Prospective

RecruitingObservational study
Ages 18 and older · All sexes · Updated Apr 16, 2026 · NCT07197736

The EMPOWER Trial - The Carillon Mitral Contour System® in Treating Heart Failure With FMR

Recruiting
Ages 18 and older · All sexes · Updated Apr 13, 2026 · NCT03142152

Mosaic Mitral Valve: Long-Term Outcomes in Patients Under 65

RecruitingObservational study
Ages 18 to 65 · All sexes · Updated Feb 20, 2026 · NCT06917586

The MITRAL II Pivotal Trial (Mitral Implantation of TRAnscatheter vaLves).

Recruiting
Ages 18 and older · All sexes · Updated Jan 13, 2026 · NCT04408430

AMEND TS Early Feasibility Study

Recruiting
Ages 21 and older · All sexes · Updated Jan 7, 2026 · NCT06951672

Novel Characterization of Sex Specific Biologic Signatures in Valvular Heart Disease

RecruitingObservational study
Ages 18 to 90 · All sexes · Updated Jan 2, 2026 · NCT06780241

Use of Phenylephrine for Assessment of Mitral Regurgitation Severity

RecruitingPhase 1/2
Ages 18 and older · All sexes · Updated Jul 20, 2025 · NCT04500899

Assessment of Transcatheter Edge-to-Edge Repair in Atrial Functional Mitral Regurgitation (ATRIAL-MR)

RecruitingObservational study
Ages 18 and older · All sexes · Updated Apr 6, 2025 · NCT06911099

An Early Feasibility Study of the HighLife 28mm Trans-Septal Transcatheter Mitral Valve Replacement System

Recruiting
Ages 18 and older · All sexes · Updated Mar 17, 2025 · NCT04029337

Assessing the Relationship Between Symptoms and Mitral Regurgitnant. Severity

RecruitingObservational study
Ages 18 and older · Men · Updated Dec 17, 2024 · NCT06738615

The Half Moon Transcatheter Mitral Valve Repair (TMVr) Pilot Study

Recruiting
Ages 21 to 95 · All sexes · Updated Jan 12, 2024 · NCT04343313

From ClinicalTrials.gov, data retrieved Sep 29, 2026. Each study sets its own eligibility; the study team decides who can join.