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Myeloproliferative Neoplasms clinical trials recruiting in the U.S.

50 studies for Myeloproliferative Neoplasms are recruiting participants at sites across the United States.

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Recently updated studies

A Randomized Study of ASTX727 With or Without Iadademstat in Advanced Myeloproliferative Neoplasms (MPNs)

RecruitingPhase 2
Ages 18 and older · All sexes · Updated Sep 29, 2026 · NCT06661915

Study of DISC-0974 (RALLY-MF) in Participants With Myelofibrosis or Myelodysplastic Syndrome and Anemia

RecruitingPhase 1/2
Ages 18 and older · All sexes · Updated Sep 23, 2026 · NCT05320198

A Phase 1 Study of PRT12396 in Participants With Select Myeloproliferative Neoplasms

RecruitingPhase 1
Ages 18 and older · All sexes · Updated Sep 18, 2026 · NCT07469891

Decitabine With Ruxolitinib, Fedratinib or Pacritinib for the Treatment of Accelerated/Blast Phase Myeloproliferative Neoplasms

RecruitingPhase 2
Ages 18 and older · All sexes · Updated Sep 17, 2026 · NCT04282187

(Apex) Bezuclastinib in Patients With Advanced Systemic Mastocytosis

RecruitingPhase 2
Ages 18 and older · All sexes · Updated Sep 15, 2026 · NCT04996875

Ivosidenib and Venetoclax With or Without Azacitidine in Treating Patients With IDH1 Mutated Hematologic Malignancies

RecruitingPhase 1/2
Ages 18 and older · All sexes · Updated Sep 14, 2026 · NCT03471260

Cord Blood Transplant in Adults With Blood Cancers

RecruitingPhase 2
Ages 21 to 65 · All sexes · Updated Sep 11, 2026 · NCT05884333

Ivosidenib and Ruxolitinib in Patients With Advanced Myeloproliferative Neoplasms (MPNs) That Have an IDH1 Gene Mutation

RecruitingPhase 1Healthy volunteers welcome
Ages 18 and older · All sexes · Updated Sep 1, 2026 · NCT06291987

Project: Every Child for Younger Patients With Cancer

RecruitingObservational study
Up to age 25 · All sexes · Updated Aug 25, 2026 · NCT02402244

CPX-351 and Ivosidenib for the Treatment of IDH1 Mutated Acute Myeloid Leukemia or High-Risk Myelodysplastic Syndrome

RecruitingPhase 2
Ages 18 and older · All sexes · Updated Aug 25, 2026 · NCT04493164

Improving Cognitive Function in Older Adults Undergoing Stem Cell Transplant

Recruiting
Ages 19 and older · All sexes · Updated Aug 19, 2026 · NCT04898790

A Study to Evaluate INCA035784 in Participants With Myeloproliferative Neoplasms

RecruitingPhase 1
Ages 18 and older · All sexes · Updated Aug 6, 2026 · NCT07008118

Ropeginterferon for High Risk JAK2 Clonal Hematopoiesis

RecruitingPhase 1
Ages 18 and older · All sexes · Updated Jul 28, 2026 · NCT07249840

Study of INCA036978 in Participants With Myeloproliferative Neoplasms

RecruitingPhase 1
Ages 18 and older · All sexes · Updated Jul 22, 2026 · NCT07441694

Evaluation of the Pathobiology of CALR-mutated MPN Cells

RecruitingObservational studyHealthy volunteers welcome
Ages 18 and older · All sexes · Updated Jul 13, 2026 · NCT06480591

Asciminib Roll-over Study

RecruitingPhase 4
Ages 7 to 100 · All sexes · Updated Jul 6, 2026 · NCT04877522

Allo HSCT Using RIC and PTCy for Hematological Diseases

RecruitingPhase 2
Up to age 75 · All sexes · Updated Jul 6, 2026 · NCT05805605

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.