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Narcolepsy clinical trials recruiting in the U.S.

15 studies for Narcolepsy are recruiting participants at sites across the United States.

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Recently updated studies

A Study to Evaluate the Efficacy and Safety of ALKS 2680 in Adults With Narcolepsy Type 1

RecruitingPhase 3
Ages 18 to 70 · All sexes · Updated Sep 3, 2026 · NCT07455383

A Phase 3 Study to Evaluate the Efficacy and Safety of Samelisant in Patients With Narcolepsy (AWAKE)

RecruitingPhase 3
Ages 18 and older · All sexes · Updated Sep 3, 2026 · NCT07540364

A Phase 3 Efficacy and Safety Study of HBS-301 in Participants With Narcolepsy

RecruitingPhase 3
Ages 18 and older · All sexes · Updated Aug 27, 2026 · NCT07675135

A Study Evaluating the Efficacy and Safety of Xywav Expanded Dosing vs Placebo in Participants With Narcolepsy or IH

RecruitingPhase 3
Ages 18 to 75 · All sexes · Updated Aug 19, 2026 · NCT07625280

A Long-Term Study of ALKS 2680 in Subjects With Narcolepsy and Idiopathic Hypersomnia

RecruitingPhase 2/3
Ages 18 to 70 · All sexes · Updated Aug 7, 2026 · NCT06767683

Decreasing Nightmares in Adults With Narcolepsy

Recruiting
Ages 18 and older · All sexes · Updated Jul 15, 2026 · NCT06383806

A Study of TAK-360 in Adults With Narcolepsy Type 1 (Narcolepsy With Cataplexy)

RecruitingPhase 2
Ages 18 to 70 · All sexes · Updated Jun 29, 2026 · NCT07633301

WAKIX® (Pitolisant) Pregnancy Registry

RecruitingObservational study
All ages · Women · Updated Jun 12, 2026 · NCT05536011

A Study to Evaluate the Efficacy and Safety of E2086 in Adults With Narcolepsy

RecruitingPhase 2
Ages 18 and older · All sexes · Updated May 14, 2026 · NCT07493265

A Long-term Extension Study of ORX750 in Participants With Narcolepsy and Idiopathic Hypersomnia

RecruitingPhase 2
Ages 18 to 65 · All sexes · Updated Apr 16, 2026 · NCT07096674

Unhide® Project: A Digital Health Platform to Collect Lifestyle Data for Brain Inflammation Research

RecruitingObservational studyHealthy volunteers welcome
Ages 2 and older · All sexes · Updated Jan 22, 2026 · NCT04806620

Extended-release Sodium Oxybate in Children

RecruitingPhase 2
Ages 7 to 17 · All sexes · Updated Nov 6, 2025 · NCT06809803

Rare Disease Patient Registry & Natural History Study - Coordination of Rare Diseases at Sanford

RecruitingObservational study
All ages · All sexes · Updated May 29, 2025 · NCT01793168

SUNOSI® (Solriamfetol) Pregnancy Registry

RecruitingObservational study
All ages · Women · Updated May 14, 2024 · NCT06413420

From ClinicalTrials.gov, data retrieved Sep 29, 2026. Each study sets its own eligibility; the study team decides who can join.