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Neuromyelitis Optica clinical trials recruiting in the U.S.

14 studies for Neuromyelitis Optica are recruiting participants at sites across the United States.

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Recently updated studies

A Study to Assess the Safety and Clinical Activity of Azer-cel in Participants With B-cell Mediated Autoimmune Disorders

RecruitingPhase 1
Ages 18 and older · All sexes · Updated Sep 9, 2026 · NCT06680037

Observational Safety Study in Women With Neuromyelitis Optica Spectrum Disorder (NMOSD) Exposed to UPLIZNA® During Pregnancy

RecruitingObservational study
Ages 15 and older · Women · Updated Aug 31, 2026 · NCT05909761

Stem Cell Ophthalmology Treatment Study II

Recruiting
Ages 18 and older · All sexes · Updated Jun 29, 2026 · NCT03011541

Registry of Patients With AQP4+ NMOSD Treated With Alexion C5 Inhibitor Therapies

RecruitingObservational study
Ages 18 and older · All sexes · Updated Jun 18, 2026 · NCT05966467

Longitudinal Cortical Demyelination in Multiple Sclerosis and Related Disorders

RecruitingObservational studyHealthy volunteers welcome
Ages 18 and older · All sexes · Updated Jun 15, 2026 · NCT05982925

Study of Ultomiris® (Ravulizumab) Safety in Pregnancy

RecruitingObservational study
All ages · Women · Updated Apr 16, 2026 · NCT06312644

Study of Inebilizumab in Pediatric Subjects With Neuromyelitis Optica Spectrum Disorder

RecruitingPhase 2
Ages 2 to 17 · All sexes · Updated Dec 5, 2025 · NCT05549258

Efgartigimod for the Treatment of Acute Optic Neuritis

RecruitingPhase 2
Ages 18 and older · All sexes · Updated Nov 10, 2025 · NCT06453694

Study of the Clinical and Radiological Impact of Ravulizumab in People With Neuromyelitis Optica Spectrum Disorder

RecruitingObservational study
Ages 18 and older · All sexes · Updated Aug 5, 2025 · NCT06398158

Biorepository and Registry for Plasma Exchange Patients

RecruitingObservational study
Ages 12 to 99 · All sexes · Updated May 20, 2025 · NCT05004493

Impact of a Structured Wellness Behavioral Intervention on Quality of Life in NMOSD

Recruiting
Ages 18 and older · All sexes · Updated Apr 17, 2025 · NCT06780709

Performance and Safety of a Digital Tool for Unsupervised Self-assessment of NMOSD

Recruiting
Ages 18 and older · All sexes · Updated Apr 10, 2025 · NCT05566769

MS-ResearchBiomarkerS

RecruitingObservational studyHealthy volunteers welcomeMentions payment for participants
Ages 18 and older · All sexes · Updated Feb 6, 2024 · NCT05204459

From ClinicalTrials.gov, data retrieved Oct 2, 2026. Each study sets its own eligibility; the study team decides who can join.