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Non-Small Cell Lung Cancer clinical trials in New York

169 studies for Non-Small Cell Lung Cancer are looking for participants at sites in New York.

Cities in New York

Testing the Addition of a Type of Drug Called Immunotherapy to the Usual Chemotherapy Treatment for Non-small Cell Lung Cancer, an ALCHEMIST Treatment Trial (Chemo-IO [ACCIO])

  • Northwell Health Imbert Cancer Center, Bay Shore
  • Maimonides Medical Center, Brooklyn
  • Roswell Park Cancer Institute, Buffalo
  • and 18 more
RecruitingPhase 3
Ages 18 and older · All sexes · Updated Oct 2, 2026 · NCT04267848

A Study of Pembrolizumab (MK-3475) With or Without Intismeran Autogene (V940) in Participants With Non-small Cell Lung Cancer (V940-009/INTerpath-009)

  • Roswell Park Cancer Institute ( Site 0184), Buffalo
  • Hematology-Oncology Associates of CNY ( Site 0164), East Syracuse
  • The Blavatnik Family- Chelsea Medical Center at Mount Sinai ( Site 0216), New York
  • and 5 more
RecruitingPhase 3
Ages 18 and older · All sexes · Updated Oct 2, 2026 · NCT06623422

Trial of Therapeutic Cancer Vaccine OSE2101 in Patients With Non-Small Cell Lung Cancer and Secondary Resistance to Immune Checkpoint Inhibitor

  • New York Cancer & Blood Specialists - New Hyde Park, New Hyde Park
  • New York Cancer & Blood Specialists - Cancer Center - Research Headquarters, New York
  • New York Cancer & Blood Specialists - Patchogue Medical Oncology, Patchogue
RecruitingPhase 3
Ages 18 and older · All sexes · Updated Oct 2, 2026 · NCT06472245

A Study of Targeted Post-Surgery Radiation Therapy for Non-Small Cell Lung Cancer With Remaining Lymph Node Cancer After Treatment

  • Memorial Sloan Kettering Commack, Commack
  • Memorial Sloan Kettering Westchester, Harrison
  • New York Proton Center, New York
  • and 9 more
RecruitingPhase 2
Ages 18 and older · All sexes · Updated Oct 2, 2026 · NCT07293247

The Evaluation of PC14586 in Patients With Advanced Solid Tumors Harboring a TP53 Y220C Mutation (PYNNACLE)

  • Columbia University Medical Center, New York
  • Memorial Sloan Kettering, New York
RecruitingPhase 1/2
Ages 12 and older · All sexes · Updated Oct 2, 2026 · NCT04585750

A Study of LY4052031 in Participants With Advanced or Metastatic Urothelial Cancer or Other Solid Tumors

  • NYU Langone Medical Center - Perlmutter Cancer Center (NYU Cancer Institute), New York
  • NYU Langone Medical Center - Perlmutter Cancer Center (NYU Cancer Institute), New York
  • Icahn School of Medicine at Mount Sinai, New York
  • and 2 more
RecruitingPhase 1
Ages 18 and older · All sexes · Updated Oct 2, 2026 · NCT06465069

A Safety and Efficacy Study of EIK1001 in Combination With Pembrolizumab and Chemotherapy in Participants With Stage 4 Non-Small Cell Lung Cancer.

  • NYU Langone Hospital Long Island, Mineola
  • NYU Langone Hospital Manhattan, New York
  • Jacobi Medical Center - Albert Einstein College of Medicine, The Bronx
  • and 1 more
RecruitingPhase 2/3
Ages 18 and older · All sexes · Updated Oct 2, 2026 · NCT07365319

A Phase 1 Study of PLN-101095 in Adults With Advanced or Metastatic Solid Tumors

  • START New York Long Island LLC, Lake Success
RecruitingPhase 1
Ages 18 and older · All sexes · Updated Oct 2, 2026 · NCT06270706

Study of Zanzalintinib in Combination With Immuno-Oncology or Other Agents in Participants With Solid Tumors

  • Exelixis Clinical Site #60, New York
  • Exelixis Clinical Site #6, New York
  • Exelixis Clinical Site #76, Syracuse
RecruitingPhase 1
Ages 18 and older · All sexes · Updated Oct 1, 2026 · NCT05176483

A Clinical Trial of Adjuvant Intismeran (V940) With or Without Pembrolizumab Coformulated With Berahyaluronidase Alfa (MK-3475A) in High-Risk Stage I Non-Small Cell Lung Cancer (V940-014)

  • New York Oncology Hematology, P.C. ( Site 9000), Albany
  • White Plains Hospital ( Site 3213), White Plains
RecruitingPhase 3
Ages 18 and older · All sexes · Updated Oct 1, 2026 · NCT07513376

A Study of HER3-DXd in Subjects With Locally Advanced or Metastatic Solid Tumors

  • Roswell Park Cancer Institute IDS, Buffalo
  • Memorial Sloan Kettering Hospital, New York
RecruitingPhase 2
Ages 18 and older · All sexes · Updated Oct 1, 2026 · NCT06172478

Testing the Impact of an Anti-Cancer Drug, Atezolizumab, After Surgery to Prevent Early Stage Non-small Cell Lung Cancer From Returning, AASI-NSCLC Trial

  • Hematology Oncology Associates of CNY at Camillus, Camillus
  • Hematology Oncology Associates of Central New York-East Syracuse, East Syracuse
  • Stony Brook University Medical Center, Stony Brook
RecruitingPhase 3
Ages 18 and older · All sexes · Updated Oct 1, 2026 · NCT07388524

Open-Label Study of BBO-10203 in Subjects With Advanced Solid Tumors

  • Columbia University Irving Medical Center, New York
  • Memorial Sloan Kettering Cancer Center, New York
RecruitingPhase 1
Ages 18 and older · All sexes · Updated Oct 1, 2026 · NCT06625775

A Clinical Trial of Calderasib (MK-1084) and Durvalumab in People With Non-Small Cell Lung Cancer (MK-1084-015/KANDLELIT-015)

  • New York Oncology Hematology P.C ( Site 9000), Albany
RecruitingPhase 3
Ages 18 and older · All sexes · Updated Oct 1, 2026 · NCT07554339

A Clinical Study of Calderasib (MK-1084) and Other Treatments for Participants With Non-Small Cell Lung Cancer (MK-1084-007/KANDLELIT-007)

  • New York Oncology Hematology, P.C. ( Site 0119), Albany
  • Wilmot Cancer Institute ( Site 0141), Rochester
RecruitingPhase 3
Ages 18 and older · All sexes · Updated Oct 1, 2026 · NCT07190248

Immunotherapy After Surgery for People Who Have No Remaining Cancer Cells After Standard Treatment for Early-Stage Non-Small Cell Lung Cancer, INSIGHT Trial

  • Montefiore Medical Center-Einstein Campus, The Bronx
  • Montefiore Medical Center-Weiler Hospital, The Bronx
  • Montefiore Medical Center - Moses Campus, The Bronx
  • and 1 more
RecruitingPhase 3
Ages 18 and older · All sexes · Updated Oct 1, 2026 · NCT06498635

A Study to Evaluate Pumitamig Versus Durvalumab Following Concurrent Chemoradiation Therapy in Participants With Unresectable Stage III Non-small Cell Lung Cancer (NSCLC) (ROSETTA Lung-201)

  • Memorial Sloan Kettering Cancer Center, New York
  • Optum Medical Care, PC, Westbury
RecruitingPhase 3
Ages 18 and older · All sexes · Updated Sep 30, 2026 · NCT07361497

A Study to Evaluate the Efficacy of Pumitamig Versus Pembrolizumab in Participants With Previously Untreated Advanced Non-Small Cell Lung Cancer and PD-L1 ≥ 50%. (ROSETTA Lung-202)

  • Local Institution - 0224, Laurelton
  • Memorial Sloan Kettering Cancer Center, New York
  • Optum Medical Care, PC, Westbury
RecruitingPhase 3
Ages 18 and older · All sexes · Updated Sep 30, 2026 · NCT07361510

A Phase 2 Study of VS-7375 in Patients With KRAS G12D-Mutated Non-Small Cell Lung Cancer

  • NYU, New York
  • Memorial Sloan Kettering Cancer Center, New York
RecruitingPhase 2
Ages 18 and older · All sexes · Updated Sep 30, 2026 · NCT07659782

Neladalkib (NVL-655) for TKI-naive Patients With Advanced ALK-Positive NSCLC

  • NYU Langone's Perlmutter Cancer Center, New York
  • Memorial Sloan Kettering Cancer Center, New York
  • Optum Medical Care, PC, Westbury
RecruitingPhase 3
Ages 18 and older · All sexes · Updated Sep 30, 2026 · NCT06765109

A Study of NT-175 in Adult Participants With Advanced Malignancies That Are Positive for HLA-A*02:01 and the TP53 R175H Mutation

  • Research Site, New York
RecruitingPhase 1
Ages 18 and older · All sexes · Updated Sep 29, 2026 · NCT05877599

Study of Daraxonrasib (RMC-6236) in Patients With RAS Mutated NSCLC (RASolve 301)

  • Roswell Park Cancer Institute, Buffalo
  • Memorial Sloan Kettering Cancer Center, New York
  • Montefiore Medical Center, The Bronx
RecruitingPhase 3
Ages 18 and older · All sexes · Updated Sep 29, 2026 · NCT06881784

A Study to Learn About the Study Medicine Called PF-08046054/SGN-PDL1V Versus Docetaxel in Adult Participants With Previously-Treated Programmed Cell Death Ligand 1 (PD-L1) Positive Non-Small-Cell Lung Cancer (NSCLC)

  • Montefiore Medical Center - Montefiore Medical Park, The Bronx
  • White Plains Hospital, White Plains
RecruitingPhase 3
Ages 18 and older · All sexes · Updated Sep 28, 2026 · NCT07144280

A Study to Assess Efficacy and Safety of Pembrolizumab With or Without Sacituzumab Tirumotecan (MK- 2870) in Adult Participants With Resectable Non Small Cell Lung Cancer (NSCLC) Not Achieving Pathological Complete Response (pCR) (MK-2870-019)

  • Cayuga Medical Center ( Site 0086), Ithaca
  • University Hospital at Stony Brook ( Site 0054), Stony Brook
  • White Plains Hospital ( Site 0091), White Plains
RecruitingPhase 3
Ages 18 and older · All sexes · Updated Sep 25, 2026 · NCT06312137

Symbiotic-Lung-01 : A Study to Learn About the Study Medicine Called PF-08634404 in Combination With Chemotherapy in Adult Participants With Locally Advanced or Metastatic Non-Small Cell Lung Cancer

  • New York Oncology Hematology, Albany
  • New York Oncology Hematology, Clifton Park
  • Hematology Oncology Associates of Rockland, Nyack
RecruitingPhase 3
Ages 18 and older · All sexes · Updated Sep 25, 2026 · NCT07222566

Phase 1 Study to Investigate TCRTs KRAS Mutation in Unresectable, Advanced, and/or Metastatic Solid Tumors

  • Research Site, New York
  • Research Site, New York
RecruitingPhase 1
Ages 18 and older · All sexes · Updated Sep 25, 2026 · NCT06218914

A Study of Amivantamab and Olomorasib Combination Therapy in Participants With Metastatic Non-Small Cell Lung Cancer

  • New York University Langone Medical Center, New York
RecruitingPhase 1/2
Ages 18 and older · All sexes · Updated Sep 25, 2026 · NCT07227025

Solid Tumor Analysis for HLA Loss of Heterozygosity (LOH) and Apheresis for CAR T- Cell Manufacturing

  • NYU Langone Medical Center, New York
RecruitingObservational study
Ages 18 and older · All sexes · Updated Sep 25, 2026 · NCT04981119

This is a Study to Learn About How the Combination of the Study Medicines Sigvotatug Vedotin Plus Pembrolizumab Works in People With Non-small Cell Lung Cancer With High Levels of PD-L1.

  • Hematology Oncology Associates of Rockland, Nyack
RecruitingPhase 3
Ages 18 and older · All sexes · Updated Sep 25, 2026 · NCT06758401

A Study of Amivantamab in Combination With Lazertinib, or Amivantamab in Combination With Platinum-Based Chemotherapy, for Common Epidermal Growth Factor Receptor (EGFR)-Mutated Locally Advanced or Metastatic Non-Small Cell Lung Cancer (NSCLC)

  • Hematology-Oncology Associates of CNY, East Syracuse
  • Laura & Isaac Perlmutter Cancer Center at NYU Langone Hospital - Long Island, Mineola
  • NYU Langone Health Laura and Isaac Perlmutter Cancer Center, New York
  • and 4 more
RecruitingPhase 2
Ages 18 and older · All sexes · Updated Sep 25, 2026 · NCT06667076

A Study of JNJ-90301900 in Combination With Chemoradiation Followed by Consolidation Immunotherapy for Non-Small Cell Lung Cancer (NSCLC)

  • NYU Langone Health, New York
  • Memorial Sloan Kettering Cancer Center, New York
RecruitingPhase 2
Ages 18 and older · All sexes · Updated Sep 25, 2026 · NCT06667908

Symbiotic-Lung-20: A Study to Learn About the Study Medicine Called PF-08634404 in Combination With Different Anticancer Agents in Advanced Cancers

  • Montefiore Medical Center- Montefiore Medical Park, The Bronx
RecruitingPhase 1/2
Ages 18 and older · All sexes · Updated Sep 25, 2026 · NCT07227298

A Global Phase III Study of Rilvegostomig or Pembrolizumab Monotherapy for First-Line Treatment of PD-L1-high Metastatic Non-small Cell Lung Cancer

  • Research Site, Buffalo
  • Research Site, East Syracuse
  • Research Site, Fresh Meadows
  • and 2 more
RecruitingPhase 3
Ages 18 and older · All sexes · Updated Sep 25, 2026 · NCT06868277

Study of Olomorasib (LY3537982) in Combination With Standard of Care in Participants With Resected or Unresectable KRAS G12C-mutant Non-Small Cell Lung Cancer

  • Columbia University Irving Medical Center, New York
  • Memorial Sloan Kettering Cancer Center, New York
  • Northport VA Medical Center, Northport
RecruitingPhase 3
Ages 18 and older · All sexes · Updated Sep 24, 2026 · NCT06890598

Pan-tumor MRD Study

  • Guthrie Lourdes Memorial Hospital (GLMH), Binghamton
  • New York Cancer & Blood Specialists, Shirley
RecruitingObservational study
Ages 18 and older · All sexes · Updated Sep 24, 2026 · NCT06605404

A Study to Compare the Efficacy of Nivolumab and Relatlimab Plus Chemotherapy vs Pembrolizumab Plus Chemotherapy for Stage IV/Recurrent Non-squamous Non-small Cell Lung Cancer With PD-L1 Expression ≥ 1%

  • Veterans Affairs New York Harbor Healthcare System, New York
  • University of Rochester Medical Center, Rochester
  • Local Institution - 0511, Schenectady
  • and 1 more
RecruitingPhase 3
Ages 18 and older · All sexes · Updated Sep 23, 2026 · NCT06561386

Intratumoral N17350 in Advanced Solid Tumors

  • Roswell Park Comprehensive Cancer Center, Buffalo
RecruitingPhase 1/2
Ages 18 and older · All sexes · Updated Sep 23, 2026 · NCT07339176

From ClinicalTrials.gov, data retrieved Oct 5, 2026. Each study sets its own eligibility; the study team decides who can join.