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Oropharyngeal Cancer clinical trials recruiting in the U.S.
56 studies for Oropharyngeal Cancer are recruiting participants at sites across the United States.
Cities with the most studies
- Chicago, IL9 studies
- Edison, NJ8 studies
- Atlanta, GA7 studies
- New York City, NY7 studies
- St. Louis, MO7 studies
- Omaha, NE7 studies
- Tampa, FL6 studies
- Houston, TX6 studies
- Detroit, MI6 studies
- Baltimore, MD6 studies
- Pittsburgh, PA6 studies
- Los Angeles, CA6 studies
- Durham, NC5 studies
- Queens, NY5 studies
- Richmond, VA5 studies
- Rochester, MN5 studies
- Washington, DC5 studies
- Milwaukee, WI5 studies
- Ann Arbor, MI4 studies
- Baldwin Park, CA4 studies
- Portland, OR4 studies
- Philadelphia, PA4 studies
- Staten Island, NY4 studies
- Greenburgh, NY4 studies
- East Norwalk, CT4 studies
- Kansas City, MO4 studies
- Aurora, IL4 studies
- Oklahoma City, OK4 studies
- Naperville, IL4 studies
- San Diego, CA4 studies
- Louisville, KY4 studies
- Cedar Rapids, IA4 studies
- Orlando, FL4 studies
- Miami, FL3 studies
- Kansas City, KS3 studies
- Overland Park, KS3 studies
- Jacksonville, FL3 studies
- New Rochelle, NY3 studies
- Nashville, TN3 studies
- Columbus, OH3 studies
By state
- Arizona5 studies
- California10 studies
- Colorado6 studies
- District of Columbia3 studies
- Florida13 studies
- Georgia7 studies
- Illinois10 studies
- Iowa6 studies
- Kansas4 studies
- Kentucky5 studies
- Maryland10 studies
- Massachusetts5 studies
- Michigan8 studies
- Minnesota7 studies
- Missouri11 studies
- Montana3 studies
- Nebraska7 studies
- New Hampshire3 studies
- New Jersey9 studies
- New Mexico3 studies
- New York11 studies
- North Carolina7 studies
- North Dakota3 studies
- Ohio8 studies
- Oklahoma5 studies
- Oregon4 studies
- Pennsylvania10 studies
- South Carolina4 studies
- Tennessee5 studies
- Texas9 studies
- Vermont3 studies
- Virginia6 studies
- Wisconsin6 studies
Recently updated studies
Testing the Addition of Ipatasertib to Usual Chemotherapy and Radiation for Head and Neck Cancer
RecruitingPhase 1
Ages 18 and older · All sexes · Updated Nov 12, 2026 · NCT05172245BiCaZO: A Study Combining Two Immunotherapies (Cabozantinib and Nivolumab) to Treat Patients With Advanced Melanoma or Squamous Cell Head and Neck Cancer, an immunoMATCH Pilot Study
RecruitingPhase 2
Ages 18 and older · All sexes · Updated Nov 12, 2026 · NCT05136196A Study to Evaluate Lenti-HPV-07 Immunotherapy Against HPV+ Cervical or Oropharyngeal Cancer
RecruitingPhase 1/2
Ages 18 and older · All sexes · Updated Nov 10, 2026 · NCT06319963A Single Arm Phase II Trial in p16-positive Oropharynx Cancer of Selective Dose De-escalation of nodAl VolumEs at Minimal Risk and Primary Site Disease (SAVED)
RecruitingPhase 2
Ages 18 and older · All sexes · Updated Nov 6, 2026 · NCT07418034Study of INBRX-106 and INBRX-106 in Combination With Pembrolizumab (Keytruda®) in Subjects With Locally Advanced or Metastatic Solid Tumors (Hexavalent OX40 Agonist)
RecruitingPhase 1/2
Ages 18 and older · All sexes · Updated Nov 6, 2026 · NCT04198766PET/CT Assessment of Radiation-Induced Vascular Complications in Head and Neck Cancer
RecruitingEarly phase 1
Ages 18 and older · All sexes · Updated Nov 4, 2026 · NCT06914999Biomarkers in Patients With Respiratory Tract Dysplasia or Lung Cancer, Head and Neck Cancer, or Aerodigestive Tract Cancer and in Normal Volunteers
RecruitingObservational study
Ages 21 to 90 · All sexes · Updated Nov 3, 2026 · NCT00900419Lymphoscintigraphy Directed Elective Neck Radiation for p16+ Favorable Risk Oropharynx Cancer
RecruitingPhase 2
Ages 18 and older · All sexes · Updated Nov 2, 2026 · NCT05800574Testing the Addition of an Anti-Cancer Drug, Camonsertib, to Radiation Therapy for Recurrent Head and Neck Squamous Cell Carcinoma
RecruitingPhase 1
Ages 18 and older · All sexes · Updated Oct 29, 2026 · NCT07156227E7 T-cell Receptor (TCR) -T Cell Induction Therapy for Locoregionally Advanced HPV-associated Cancers
RecruitingPhase 1/2
Ages 18 and older · All sexes · Updated Oct 28, 2026 · NCT05639972Ordastobart (INBRX-106) Add-on to Pembrolizumab in 1L HPV+ PD-L1+ R/M OPSCC (HexAgon-HN)
RecruitingPhase 2/3
Ages 18 and older · All sexes · Updated Oct 28, 2026 · NCT06295731E7 TCR-T Cell Immunotherapy for Human Papillomavirus (HPV) Associated Cancers
RecruitingPhase 2
Ages 18 and older · All sexes · Updated Oct 28, 2026 · NCT05686226TMV Vaccine Alone or With Toripalimab-tpzi for Recurrent Head and Neck Squamous Cell Carcinoma
RecruitingPhase 1
Ages 18 and older · All sexes · Updated Oct 27, 2026 · NCT07898124Testing the Addition of Chemotherapy or Chemo-Immunotherapy to the Usual Surgery for Advanced Head and Neck Cancer
RecruitingPhase 2
Ages 18 and older · All sexes · Updated Oct 26, 2026 · NCT07195734Phase II Trial of Neoadjuvant Chemotherapy (NAC) Alone or in Combination With Immunotherapy Vaccine PRGN-2009 in Subjects With Newly Diagnosed HPV-Associated Oropharyngeal (Head and Neck) Cancer
RecruitingPhase 2
Ages 18 to 120 · All sexes · Updated Oct 19, 2026 · NCT06223568A Study to Evaluate CRB-701 Compared to Investigator's Choice Therapy in Previously Treated Oropharyngeal Squamous Cell Carcinoma
RecruitingPhase 3
Ages 18 and older · All sexes · Updated Oct 8, 2026 · NCT07768189Blood Tests and Questionnaires in Studying Adherence to Preventative Swallowing Exercises in Participants With Metastatic Head and Neck Cancer
RecruitingObservational study
Ages 18 and older · All sexes · Updated Oct 6, 2026 · NCT03010150Intraoperative Methadone for the Management of Postoperative Pain in Patients With Head and Neck Cancers
RecruitingPhase 4
Ages 18 to 89 · All sexes · Updated Oct 5, 2026 · NCT07857655De-Escalated Adjuvant and Definitive Radiation Therapy Informed by DART 2.0 ctHPV-DNA
RecruitingPhase 2
Ages 18 and older · All sexes · Updated Oct 1, 2026 · NCT05541016Methotrexate, Erlotinib, and Celecoxib for the Treatment of Recurrent/Metastatic Head and Neck Cancer in a Rural Midwest United States Population
RecruitingPhase 2
Ages 18 and older · All sexes · Updated Oct 1, 2026 · NCT06997068Dose Adjusted Chemoradiotherapy in HPV-Associated Oropharynx Cancer of the Elderly
Recruiting
Ages 65 to 99 · All sexes · Updated Sep 29, 2026 · NCT06309225Biomarker Approach to Screening for the Early Detection of HPV-related Oropharyngeal Cancer (BASH OPC)
RecruitingObservational studyHealthy volunteers welcome
Ages 18 and older · All sexes · Updated Sep 23, 2026 · NCT06305676Multidimensional and Multimodal Profiling of Oropharyngeal Carcinoma
RecruitingObservational study
Ages 18 and older · All sexes · Updated Sep 15, 2026 · NCT05880797Testing the Addition of the Drug BMX-001, a Radioprotector, or a Placebo to the Usual Chemoradiation Therapy for Patients With Head and Neck Cancer
RecruitingPhase 2
Ages 18 and older · All sexes · Updated Aug 17, 2026 · NCT06532279Pre-operative Atezolizumab in Patients With Resectable, Human Papillomavirus Related Oropharyngeal Carcinoma
RecruitingPhase 2
Ages 18 and older · All sexes · Updated Aug 5, 2026 · NCT06254911From ClinicalTrials.gov, data retrieved Nov 15, 2026. Each study sets its own eligibility; the study team decides who can join.