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Primary Ovarian Insufficiency clinical trials recruiting in the U.S.
8 studies for Primary Ovarian Insufficiency are recruiting participants at sites across the United States.
Primary ovarian insufficiency(POI) happens when a woman's ovaries stop working before she is 40. POI is different from premature menopause. Learn about the causes, and how to treat the symptoms and complications.
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Recently updated studies
Gonadotropin-releasing Hormone Agonist (GnRHa) in Ovarian Preservation in SLE Subjects Receiving Cyclophosphamide as Determined by Questionnaires
RecruitingObservational study
Ages 18 to 120 · Women · Updated Sep 28, 2026 · NCT05567198Hormone Replacement Therapy in Adolescents With Premature Ovarian Insufficiency
RecruitingPhase 3Healthy volunteers welcome
Ages 11 to 19 · Women · Updated Sep 18, 2026 · NCT06851754Effects of Estrogen on Heart Health in Women With Primary Ovarian Insufficiency
RecruitingObservational studyHealthy volunteers welcome
Ages 30 to 40 · Women · Updated Sep 8, 2026 · NCT06866119Bleeding Patterns in Sequential and Continuous Progesterone Supplementation in Adolescents With Turner Syndrome
RecruitingPhase 4
Ages 12 to 20 · Women · Updated Aug 25, 2026 · NCT06834594Poi for Mama: a Pilot to Improve Maternal Microbiome and Gestational Diabetes Risk
Recruiting
Ages 18 and older · Women · Updated Jul 2, 2026 · NCT07446205Improving Outcomes in Early Menopause After Cancer
Recruiting
Ages 18 to 44 · Women · Updated May 14, 2026 · NCT06982677Identifying Genome Variants in Non-Obstructive Azoospermia (NOA) or Primary Ovarian Insufficiency (POI)
RecruitingObservational study
Ages 18 to 100 · All sexes · Updated Mar 16, 2026 · NCT07357701Assessment of Endometrial Thickness Among Adolescent and Young Adult Patients on Estrogen Replacement Therapy Using Daily Oral Micronized Progesterone Versus the Etonogestrel Implant.
RecruitingObservational studyMentions payment for participants
Ages 12 to 25 · Women · Updated Dec 6, 2024 · NCT06357442From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.