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Restless Legs clinical trials recruiting in the U.S.

5 studies for Restless Legs are recruiting participants at sites across the United States.

That creeping, crawling, tingling, or burning feeling in your legs when lying down or sitting may be restless leg syndrome (RLS). Learn what can help.

By state

Recently updated studies

Optimizing Extended-Duration (XD-) TOMAC Therapy for Restless Legs Syndrome (RLS)

Recruiting
Ages 21 and older · All sexes · Updated Jun 30, 2026 · NCT07675109

The Effect of Spinal Cord Stimulators on Restless Leg Syndrome

RecruitingHealthy volunteers welcome
Ages 18 and older · All sexes · Updated Jun 26, 2026 · NCT07179406

Peroneal Electrical Nerve Stimulation in Pregnancy for Restless Legs Syndrome

Recruiting
Ages 18 and older · Women · Updated Nov 12, 2025 · NCT07144631

Observe Change in Nasal Swab DRD2 Gene Expression in Restless Legs Syndrome (RLS) Patients on Prolonged Dopamine Agonist Treatment

RecruitingObservational study
Ages 18 to 60 · All sexes · Updated Sep 11, 2025 · NCT06726785

Blood Changes After Exercise in Restless Legs Syndrome

Recruiting
Ages 18 and older · All sexes · Updated Nov 27, 2024 · NCT06481176

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.