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Seizures clinical trials recruiting in the U.S.

55 studies for Seizures are recruiting participants at sites across the United States.

Seizures are caused by sudden, abnormal electrical activity in the brain. They can be mild or severe. Learn about the types, causes, and treatments.

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Recently updated studies

Study Evaluating the Efficacy and Safety of RAP-219 in Adult Participants With Focal Seizures FOCUS-1

RecruitingPhase 3
Ages 18 to 75 ยท All sexes ยท Updated Nov 12, 2026 ยท NCT07563881

Study Evaluating the Efficacy and Safety of RAP-219 in Adult Participants With Focal Seizures

RecruitingPhase 3
Ages 18 to 75 ยท All sexes ยท Updated Nov 12, 2026 ยท NCT07594119

Tumor Related Epilepsy

RecruitingObservational study
Ages 8 to 99 ยท All sexes ยท Updated Nov 12, 2026 ยท NCT02639325

Investigate Efficacy and Safety of Carisbamate as Adjunctive Treatment for Seizures Associated With LGS in Children and Adults

RecruitingPhase 3
Ages 4 to 55 ยท All sexes ยท Updated Nov 6, 2026 ยท NCT05219617

Genetic Markers of Cardiovascular Disease in Epilepsy

RecruitingObservational study
Ages 18 to 50 ยท All sexes ยท Updated Nov 3, 2026 ยท NCT02824822

A Randomized Study of XEN1101 Versus Placebo in Focal-Onset Seizures (X-TOLE3)

RecruitingPhase 3
Ages 18 and older ยท All sexes ยท Updated Nov 2, 2026 ยท NCT05716100

HOBSCOTCH-YOUTH and Young Adults

Recruiting
Ages 13 to 29 ยท All sexes ยท Updated Nov 2, 2026 ยท NCT07735715

Mapping of Human Cognition

Recruiting
Ages 18 to 75 ยท All sexes ยท Updated Nov 2, 2026 ยท NCT05989893

Study of NRTX-1001 Neural Cell Therapy in Drug-Resistant Unilateral Mesial Temporal Lobe Epilepsy (EPIC (EPIlepsy Cell Therapy))

RecruitingPhase 3
Ages 18 to 75 ยท All sexes ยท Updated Oct 30, 2026 ยท NCT05135091

Natural History of Treated Neurocysticercosis and Long-Term Outcomes

RecruitingObservational studyHealthy volunteers welcome
Ages 3 to 99 ยท All sexes ยท Updated Oct 29, 2026 ยท NCT00001205

Investigation of Blood-Brain-Barrier Breakdown Using Manganese Magnetic Resonance Imaging in Drug-Resistant Epilepsy

RecruitingPhase 1
Ages 18 to 60 ยท All sexes ยท Updated Oct 29, 2026 ยท NCT02531880

A Study of EPX-100 (Clemizole Hydrochloride) in Participants With Dravet Syndrome

RecruitingPhase 3
Ages 2 and older ยท All sexes ยท Updated Oct 29, 2026 ยท NCT04462770

Investigating Epilepsy: Screening and Evaluation

RecruitingObservational study
Ages 8 to 110 ยท All sexes ยท Updated Oct 26, 2026 ยท NCT03478852

Oxygen Toxicity: Mechanisms in Humans

RecruitingHealthy volunteers welcome
Ages 18 to 45 ยท All sexes ยท Updated Oct 21, 2026 ยท NCT05761756

Ear-Seizure Detection (EarSD) Study

RecruitingHealthy volunteers welcome
Ages 18 and older ยท All sexes ยท Updated Oct 14, 2026 ยท NCT06598189

Clinical and Electrographic Changes in Responsive Neurostimulation System (RNS) Patients With Acupuncture Treatment

Recruiting
Ages 15 to 60 ยท All sexes ยท Updated Oct 13, 2026 ยท NCT04677751

An Efficacy and Safety Study of Clemizole HCl in Patients With Lennox-Gastaut Syndrome

RecruitingPhase 3
Ages 2 to 55 ยท All sexes ยท Updated Oct 9, 2026 ยท NCT05066217

Pharmacological Modulation of Brain Oscillations in Memory Processing

RecruitingEarly phase 1Healthy volunteers welcome
Ages 18 to 55 ยท All sexes ยท Updated Oct 5, 2026 ยท NCT05594017

RENAISSANCE 2: SPN-817 Phase 2, Double-Blind, Placebo-Controlled Study in Adults With Focal Onset Seizures

RecruitingPhase 2
Ages 18 to 70 ยท All sexes ยท Updated Oct 1, 2026 ยท NCT06798896

Optimizing Therapy in Epilepsy Using Seizure Forecasts Via EEG and Wearables

RecruitingEarly phase 1Mentions payment for participants
Ages 18 to 75 ยท All sexes ยท Updated Sep 25, 2026 ยท NCT07012148

Modulating Movement Intention Via Cortical Stimulation

RecruitingHealthy volunteers welcome
Ages 18 to 65 ยท All sexes ยท Updated Sep 25, 2026 ยท NCT03233399

Acute Effects of Focused Ultrasound Modulation on EEG Behavior in Status Epilepticus Patients

Recruiting
Ages 19 to 85 ยท All sexes ยท Updated Sep 21, 2026 ยท NCT05784805

Ketogenic Therapy Effects on Electrical and Metabolic Abnormalities in Epilepsy

Recruiting
Up to age 50 ยท All sexes ยท Updated Sep 17, 2026 ยท NCT02216500

Prospective Natural History Study of POLG Disease

RecruitingObservational study
All ages ยท All sexes ยท Updated Sep 15, 2026 ยท NCT07775872

From ClinicalTrials.gov, data retrieved Nov 15, 2026. Each study sets its own eligibility; the study team decides who can join.