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Sexually Transmitted Infections clinical trials recruiting in the U.S.

19 studies for Sexually Transmitted Infections are recruiting participants at sites across the United States.

Sexually transmitted infections (STIs) are passed from person to person during sexual contact. Testing, vaccines, and prevention behaviors can lower your risk.

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Recently updated studies

Improving Maternal and Child Health Through Point-of-care STI Testing

RecruitingHealthy volunteers welcome
All ages · Women · Updated Aug 19, 2026 · NCT07290439

Evaluation of the Q-Pad hrHPV Test System for Identifying Precancer

RecruitingHealthy volunteers welcome
Ages 25 and older · Women · Updated Jul 24, 2026 · NCT07281599

Health-E You Efficacy Trial for Male Adolescents

RecruitingHealthy volunteers welcome
Ages 13 to 21 · Men · Updated Jul 15, 2026 · NCT06525064

Improving Alcohol and Substance Use Care Access, Outcome, Equity During the Reproductive Years

Recruiting
Ages 18 and older · All sexes · Updated Jun 15, 2026 · NCT05910580

Appalachian Partnership to Reduce Disparities (Aim 2)

RecruitingHealthy volunteers welcome
Ages 18 and older · All sexes · Updated May 26, 2026 · NCT04378439

Gathering Online for Dialogue and Discussion to Enhance Social Support

RecruitingHealthy volunteers welcome
Ages 18 to 30 · All sexes · Updated May 19, 2026 · NCT05753683

Doxycycline Prophylaxis for Prevention of Sexually Transmitted Infections

RecruitingPhase 4
Ages 13 to 29 · Women · Updated May 15, 2026 · NCT06738407

Point of Care STI Testing

Recruiting
Ages 16 to 24 · All sexes · Updated May 5, 2026 · NCT06844045

"Sexual Health Assessment of TinidaZole Against M. Genitalium (SHAZAM)"

RecruitingPhase 2
Ages 18 and older · Men · Updated May 4, 2026 · NCT07088419

Got Doxy- 'Flipping the Script' on STI PEP

RecruitingPhase 4Healthy volunteers welcome
Ages 18 and older · Men · Updated Apr 30, 2026 · NCT07215325

IMARA for Black Male Caregivers and Girls Empowerment (IMAGE)

RecruitingHealthy volunteers welcome
Ages 13 and older · All sexes · Updated Apr 17, 2026 · NCT06266416

California MEPS Hub

RecruitingHealthy volunteers welcome
Ages 18 to 59 · Men · Updated Apr 3, 2026 · NCT07433985

Health Information Technology to Reduce Disparities in Adolescent Health Outcomes: A Pragmatic Trial

RecruitingHealthy volunteers welcome
Ages 15 to 21 · All sexes · Updated Mar 18, 2026 · NCT04372875

Assessing Acceptability and Feasibiity of STI Self-swab Testing, to be Offered at the Time of Telemed Medication Abortion Provision

RecruitingHealthy volunteers welcome
Ages 14 and older · Women · Updated Jun 26, 2025 · NCT06951438

Evaluation of Parent Toolkit 2.0 (Morehouse Family Health Study)

RecruitingHealthy volunteers welcome
Ages 12 to 15 · All sexes · Updated Apr 30, 2025 · NCT06579781

Using Mobile Health (mHealth) to Improve STI Treatment Adherence Among Adolescents

Recruiting
Ages 15 to 21 · All sexes · Updated Aug 21, 2024 · NCT04372485

Evaluation of the SafeSpace App Intervention

RecruitingHealthy volunteers welcome
Ages 14 to 18 · Women · Updated Nov 21, 2023 · NCT06043596

Comparing Mobile Health Strategies to Improve Pre-exposure Prophylaxis Use (PrEP) for HIV Prevention

RecruitingHealthy volunteers welcome
Ages 15 and older · All sexes · Updated Sep 28, 2022 · NCT04855773

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.