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Short Bowel Syndrome clinical trials recruiting in the U.S.
8 studies for Short Bowel Syndrome are recruiting participants at sites across the United States.
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Recently updated studies
Rare Disease Patient Registry & Natural History Study - Coordination of Rare Diseases at Sanford
RecruitingObservational study
All ages · All sexes · Updated Oct 28, 2026 · NCT01793168Efficacy And Safety Evaluation of Glepaglutide in Treatment of SBS
RecruitingPhase 3
Ages 18 to 90 · All sexes · Updated Sep 29, 2026 · NCT07197944A Feasibility Study to Evaluate Safety and Probable Benefit of the Eclipse XL1 System for Distraction Enterogenesis in Adult and Pediatric Patients With Short Bowel Syndrome
Recruiting
3 Months – 65 Years · All sexes · Updated Aug 12, 2026 · NCT05535361Phase 2 Study to Assess the Safety, PK, and PD of Sonefpeglutide (HM15912) in SBS-IF Subjects
RecruitingPhase 2
Ages 18 and older · All sexes · Updated Aug 12, 2026 · NCT04775706A Study to Investigate the Efficacy and Safety of Apraglutide Compared With Placebo in Adult Participants With Short Bowel Syndrome Associated With Intestinal Failure (SBS-IF)
RecruitingPhase 3
Ages 18 and older · All sexes · Updated Aug 4, 2026 · NCT07742735A 90 Day, Phase 3,Open Labeled Exploratory Study of RELiZORB
Recruiting
Ages 2 to 18 · All sexes · Updated Aug 3, 2026 · NCT03530852Fiber Food Introduction in Pediatric Short Bowel Syndrome
RecruitingHealthy volunteers welcome
4 Months – 18 Years · All sexes · Updated Jul 10, 2026 · NCT05432648Prospective Multisite Study of Quality of Life in Pediatric Intestinal Failure
RecruitingObservational study
6 Months – 25 Years · All sexes · Updated Mar 23, 2026 · NCT04629014From ClinicalTrials.gov, data retrieved Nov 15, 2026. Each study sets its own eligibility; the study team decides who can join.