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Sjogren's Syndrome clinical trials recruiting in the U.S.

16 studies for Sjogren's Syndrome are recruiting participants at sites across the United States.

Sjogren's Syndrome is an autoimmune disease that causes dryness of the mouth, eyes and other parts of the body. Learn how to relieve the symptoms.

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Recently updated studies

Characterization of Diseases With Salivary Gland Involvement

RecruitingObservational studyHealthy volunteers welcome
Ages 4 to 100 · All sexes · Updated Sep 28, 2026 · NCT02327884

A Phase 2a/b Study to Assess the Efficacy, Safety and Tolerability of DDY391 in Participants With Sjögren's Disease

RecruitingPhase 2
Ages 18 to 100 · All sexes · Updated Sep 25, 2026 · NCT07737743

The Pathogenesis and Natural History of Sjogren's Disease

RecruitingObservational study
Ages 16 to 100 · All sexes · Updated Sep 24, 2026 · NCT01425892

Testing an Immunotherapy Anti-cancer Drug, Nivolumab, for Advanced Cancers in Patients With Autoimmune Disorders, AIM-NIVO

RecruitingPhase 1
Ages 18 and older · All sexes · Updated Sep 23, 2026 · NCT03816345

Safety of Tofacitinib, an Oral Janus Kinase Inhibitor, in Primary Sjogren Disease

RecruitingPhase 2
Ages 18 to 75 · All sexes · Updated Sep 17, 2026 · NCT07281456

Phase 3 Study of Telitacicept in Active Primary Sjögren's Disease

RecruitingPhase 3
Ages 18 to 75 · All sexes · Updated Aug 27, 2026 · NCT07404865

Dose-Escalation Trial of Mesenchymal Stromal Cells in Patients With Medical Xerostomia

RecruitingPhase 1
Ages 18 to 90 · All sexes · Updated Aug 19, 2026 · NCT06392711

A Study of CLN-978, a Subcutaneously Administered CD19-directed T Cell Engager, in Subjects With Sjogren's Disease

RecruitingPhase 1
Ages 18 and older · All sexes · Updated Aug 11, 2026 · NCT07041099

Creating Health Course Study for People With Rheumatological Conditions and Mood Disorders

Recruiting
Ages 18 to 100 · All sexes · Updated Aug 10, 2026 · NCT07180537

A Long-term Extension Study of Dazodalibep in Participants With Sjögren's Syndrome (SS)

RecruitingPhase 3
Ages 18 and older · All sexes · Updated Apr 28, 2026 · NCT06747949

Rheumatology Patient Registry and Biorepository

RecruitingObservational studyHealthy volunteers welcome
Ages 18 to 99 · All sexes · Updated Feb 13, 2026 · NCT04402086

Maternal Autoimmune Disease Research Alliance (MADRA) Registry

RecruitingObservational studyHealthy volunteers welcome
All ages · Women · Updated Jan 8, 2026 · NCT03276923

The Myelin Disorders Biorepository Project

RecruitingObservational study
All ages · All sexes · Updated Oct 23, 2025 · NCT03047369

Rheumatology Diet Study

RecruitingObservational study
Ages 18 to 65 · All sexes · Updated Dec 6, 2024 · NCT06339957

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.