Home › Sjogren's Syndrome
Sjogren's Syndrome clinical trials recruiting in the U.S.
16 studies for Sjogren's Syndrome are recruiting participants at sites across the United States.
Sjogren's Syndrome is an autoimmune disease that causes dryness of the mouth, eyes and other parts of the body. Learn how to relieve the symptoms.
Cities with the most studies
- Houston, TX6 studies
- Boston, MA5 studies
- Washington, DC5 studies
- Charlotte, NC4 studies
- Tampa, FL4 studies
- Arlington, TX4 studies
- Cicero, IL4 studies
- Warren, MI3 studies
- Clearwater, FL3 studies
- Tucson, AZ3 studies
- Kansas City, MO3 studies
- Cypress, TX3 studies
- Chicago, IL3 studies
- Dallas, TX3 studies
- Orlando, FL3 studies
By state
- Arizona4 studies
- California5 studies
- Florida7 studies
- Illinois5 studies
- Maryland6 studies
- Massachusetts5 studies
- Michigan3 studies
- Missouri3 studies
- New York3 studies
- North Carolina6 studies
- Ohio3 studies
- Pennsylvania4 studies
- Tennessee4 studies
- Texas8 studies
- Virginia3 studies
- Washington3 studies
Recently updated studies
Two Arm, Double-blind, Phase III Study Assessing Efficacy and Safety of Ianalumab Versus Placebo, in Participants With Sjögren's Disease With High Symptom Burden
RecruitingPhase 3
Ages 18 and older · All sexes · Updated Sep 28, 2026 · NCT07621809Characterization of Diseases With Salivary Gland Involvement
RecruitingObservational studyHealthy volunteers welcome
Ages 4 to 100 · All sexes · Updated Sep 28, 2026 · NCT02327884A Phase 2a/b Study to Assess the Efficacy, Safety and Tolerability of DDY391 in Participants With Sjögren's Disease
RecruitingPhase 2
Ages 18 to 100 · All sexes · Updated Sep 25, 2026 · NCT07737743The Pathogenesis and Natural History of Sjogren's Disease
RecruitingObservational study
Ages 16 to 100 · All sexes · Updated Sep 24, 2026 · NCT01425892Testing an Immunotherapy Anti-cancer Drug, Nivolumab, for Advanced Cancers in Patients With Autoimmune Disorders, AIM-NIVO
RecruitingPhase 1
Ages 18 and older · All sexes · Updated Sep 23, 2026 · NCT03816345Safety of Tofacitinib, an Oral Janus Kinase Inhibitor, in Primary Sjogren Disease
RecruitingPhase 2
Ages 18 to 75 · All sexes · Updated Sep 17, 2026 · NCT07281456Phase 3 Study of Telitacicept in Active Primary Sjögren's Disease
RecruitingPhase 3
Ages 18 to 75 · All sexes · Updated Aug 27, 2026 · NCT07404865Dose-Escalation Trial of Mesenchymal Stromal Cells in Patients With Medical Xerostomia
RecruitingPhase 1
Ages 18 to 90 · All sexes · Updated Aug 19, 2026 · NCT06392711A Study of CLN-978, a Subcutaneously Administered CD19-directed T Cell Engager, in Subjects With Sjogren's Disease
RecruitingPhase 1
Ages 18 and older · All sexes · Updated Aug 11, 2026 · NCT07041099Creating Health Course Study for People With Rheumatological Conditions and Mood Disorders
Recruiting
Ages 18 to 100 · All sexes · Updated Aug 10, 2026 · NCT07180537AlloNK®, an Allogeneic Non-genetically Modified, Cord Blood-derived NK Cell Therapy, in Combination With Rituximab, Studied in Relapsing Forms of B-cell Dependent Rheumatologic Diseases.
RecruitingPhase 2
Ages 18 and older · All sexes · Updated Jul 31, 2026 · NCT06991114A Long-term Extension Study of Dazodalibep in Participants With Sjögren's Syndrome (SS)
RecruitingPhase 3
Ages 18 and older · All sexes · Updated Apr 28, 2026 · NCT06747949Rheumatology Patient Registry and Biorepository
RecruitingObservational studyHealthy volunteers welcome
Ages 18 to 99 · All sexes · Updated Feb 13, 2026 · NCT04402086Maternal Autoimmune Disease Research Alliance (MADRA) Registry
RecruitingObservational studyHealthy volunteers welcome
All ages · Women · Updated Jan 8, 2026 · NCT03276923The Myelin Disorders Biorepository Project
RecruitingObservational study
All ages · All sexes · Updated Oct 23, 2025 · NCT03047369Rheumatology Diet Study
RecruitingObservational study
Ages 18 to 65 · All sexes · Updated Dec 6, 2024 · NCT06339957From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.