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Skin Cancer clinical trials recruiting in the U.S.
46 studies for Skin Cancer are recruiting participants at sites across the United States.
Try ABCDE on a mole to check for signs of skin cancer: Asymmetry, Border, Color, Diameter, Elevation. Learn more on advanced detection and treatments.
Cities with the most studies
- Boston, MA9 studies
- Tampa, FL8 studies
- New York City, NY7 studies
- Salt Lake City, UT6 studies
- Washington, DC6 studies
- Pittsburgh, PA6 studies
- Rochester, MN5 studies
- St. Louis, MO5 studies
- Houston, TX5 studies
- Miami, FL5 studies
- Los Angeles, CA5 studies
- Edison, NJ4 studies
- Aurora, CO4 studies
- Jacksonville, FL4 studies
- Orlando, FL4 studies
- Dayton, OH3 studies
- Morgantown, WV3 studies
- Oklahoma City, OK3 studies
- Cincinnati, OH3 studies
- Mountain View, CA3 studies
- Providence, RI3 studies
- Birmingham, AL3 studies
- Atlanta, GA3 studies
- Seattle, WA3 studies
- Kansas City, MO3 studies
- Baldwin Park, CA3 studies
- San Francisco, CA3 studies
- Portland, OR3 studies
- Phoenix, AZ3 studies
By state
- Alabama3 studies
- Arizona5 studies
- Arkansas3 studies
- California7 studies
- Colorado5 studies
- Florida15 studies
- Georgia3 studies
- Illinois3 studies
- Maryland8 studies
- Massachusetts11 studies
- Minnesota8 studies
- Missouri6 studies
- New Hampshire3 studies
- New Jersey6 studies
- New York10 studies
- North Carolina4 studies
- Ohio7 studies
- Oklahoma4 studies
- Oregon3 studies
- Pennsylvania8 studies
- Rhode Island3 studies
- Texas6 studies
- Utah6 studies
- Virginia3 studies
- Washington4 studies
- West Virginia3 studies
Recently updated studies
Evaluating Photodynamic Therapy Used to Treat Cutaneous Squamous Cell Carcinoma in Situ (isSCC) on the Face, Upper Extremities & Trunk.
RecruitingPhase 2
Ages 18 and older ยท All sexes ยท Updated Nov 12, 2026 ยท NCT07931664A Multilevel Approach to Connecting Underrepresented Populations to Clinical Trials
RecruitingObservational studyHealthy volunteers welcome
Ages 18 to 100 ยท All sexes ยท Updated Nov 5, 2026 ยท NCT05655494Safety and Efficacy of OBX-115 in Advanced Solid Tumors
RecruitingPhase 1/2
Ages 18 and older ยท All sexes ยท Updated Nov 3, 2026 ยท NCT06060613Clinical, Laboratory, and Epidemiologic Characterization of Individuals and Families at High Risk of Melanoma
RecruitingObservational studyHealthy volunteers welcome
4 Weeks โ 99 Years ยท All sexes ยท Updated Oct 29, 2026 ยท NCT00040352A Phase 0 Window of Opportunity Trial of Intratumoral Seasonal Influenza Immunization in Cutaneous Squamous Cell Carcinoma (CSCC) Patients Awaiting Curative Excision
RecruitingEarly phase 1
Ages 18 and older ยท All sexes ยท Updated Oct 19, 2026 ยท NCT06664151Cemiplimab and Quad Shot Radiation for Cutaneous Squamous Cell Carcinoma in the Head and Neck
RecruitingEarly phase 1
Ages 18 and older ยท All sexes ยท Updated Oct 13, 2026 ยท NCT07869823Mobile Sun Health Intervention EnabLing Daily Protection
RecruitingHealthy volunteers welcome
Ages 18 to 29 ยท All sexes ยท Updated Sep 24, 2026 ยท NCT07830394Study to Investigate Lifileucel Regimen Plus Pembrolizumab Compared With Pembrolizumab Alone in Participants With Untreated Advanced Melanoma.
RecruitingPhase 3
Ages 18 to 70 ยท All sexes ยท Updated Sep 24, 2026 ยท NCT05727904Study of Intralesional Cemiplimab in Adult Patients With Early Stage Cutaneous Squamous Cell Carcinoma
RecruitingPhase 3
Ages 18 and older ยท All sexes ยท Updated Sep 16, 2026 ยท NCT06585410Minibeam Radiation Therapy With Tungsten Slit Collimator for the Treatment of Recurrent or Metastatic Skin or Soft Tissue Tumors
Recruiting
Ages 18 and older ยท All sexes ยท Updated Sep 11, 2026 ยท NCT07062003Cryoablation+Ipilimumab+Nivolumab in Melanoma
RecruitingPhase 2
Ages 18 and older ยท All sexes ยท Updated Aug 27, 2026 ยท NCT05779423A Phase 2 Trial for Metastatic Melanoma Using Adoptive Cell Therapy With Tumor Infiltrating Lymphocytes Plus IL-2 Either Alone or Following the Administration of Pembrolizumab
RecruitingPhase 2
Ages 18 to 72 ยท All sexes ยท Updated Aug 20, 2026 ยท NCT02621021High-Intensity Exercise and High-Fiber Diet for Immunotherapy Outcomes in Melanoma Patients: The DUO Trial
Recruiting
Ages 18 and older ยท All sexes ยท Updated Aug 19, 2026 ยท NCT06298734A Study of MQ710 With and Without Pembrolizumab in People With Solid Tumor Cancer
RecruitingPhase 1
Ages 18 and older ยท All sexes ยท Updated Aug 12, 2026 ยท NCT05859074Cosibelimab for CSCC in Patients With Kidney Transplant or Hematologic Malignancy
RecruitingPhase 4
Ages 18 and older ยท All sexes ยท Updated Aug 11, 2026 ยท NCT07426484Rural Adult and Youth Sun Protection Study
RecruitingHealthy volunteers welcome
Ages 3 to 7 ยท All sexes ยท Updated Aug 10, 2026 ยท NCT06439979Digital Remote Monitoring of Immune Checkpoint Inhibitor Therapy Induced Toxicity Using the Vigilant App
RecruitingObservational study
Ages 18 and older ยท All sexes ยท Updated Aug 6, 2026 ยท NCT06675643The Florida ASCENT Study
Recruiting
Ages 18 to 100 ยท All sexes ยท Updated Jul 23, 2026 ยท NCT07042243DNA Repair Activity in the Skin of Day and Night Shift Workers
RecruitingHealthy volunteers welcome
Ages 18 to 40 ยท All sexes ยท Updated Jul 17, 2026 ยท NCT04122456Alpha Radiation Emitters Device (DaRT) for the Treatment of Cutaneous SCC for Immunocompromised Patients
Recruiting
Ages 18 and older ยท All sexes ยท Updated Jul 15, 2026 ยท NCT06615635Predicting Response to Immunotherapy From Analysis of Live Tumor Biopsies (ELEPHAS-05)
RecruitingObservational study
Ages 18 and older ยท All sexes ยท Updated Jun 29, 2026 ยท NCT07327489Integrated Cancer Repository for Cancer Research
RecruitingObservational studyHealthy volunteers welcome
Ages 19 to 110 ยท All sexes ยท Updated Jun 29, 2026 ยท NCT02012699Neoadjuvant Cemiplimab in Newly Diagnosed or Recurrent Stage I-II Merkel Cell Carcinoma and Locoregionally Advanced Cutaneous Squamous Cell Carcinoma
RecruitingPhase 1
Ages 18 and older ยท All sexes ยท Updated Jun 25, 2026 ยท NCT04975152A Study to Investigate the Efficacy and Safety of an Infusion of IOV-4001 in Adult Participants With Unresectable or Metastatic Melanoma or Stage III or IV Non-small-cell Lung Cancer
RecruitingPhase 1/2
Ages 18 to 70 ยท All sexes ยท Updated Jun 11, 2026 ยท NCT05361174A Randomized Controlled Trial of Topical 5% Niacinamide for Skin Cancer Prevention in Transplant Recipients
RecruitingEarly phase 1
Ages 18 and older ยท All sexes ยท Updated Jun 5, 2026 ยท NCT07286318From ClinicalTrials.gov, data retrieved Nov 15, 2026. Each study sets its own eligibility; the study team decides who can join.