USC/Norris Comprehensive Cancer Center, Los Angeles
University of California, Irvine (UCI) Health - UC Irvine Medical Center, Orange
Local Institution - 0428, San Francisco

RecruitingPhase 2/3

Ages 18 and older · All sexes · Updated Nov 5, 2026 · NCT07221149

cfDNA Assay Prospective Observational Validation for Early Cancer Detection and Minimal Residual Disease

City of Hope, Duarte

RecruitingObservational studyHealthy volunteers welcome

Ages 40 and older · All sexes · Updated Nov 4, 2026 · NCT05366881

Collecting Blood Samples From Patients With and Without Cancer to Evaluate Tests for Early Cancer Detection

Mission Hope Medical Oncology - Arroyo Grande, Arroyo Grande
PCR Oncology, Arroyo Grande
AIS Cancer Center at San Joaquin Community Hospital, Bakersfield
and 22 more

RecruitingObservational studyHealthy volunteers welcome

Ages 40 to 75 · All sexes · Updated Nov 4, 2026 · NCT05334069

Studying the PAGODA Algorithm for Chemotherapy Dose Changes to Prevent Unplanned Treatment Delays

Mission Hope Medical Oncology - Arroyo Grande, Arroyo Grande
Mercy Cancer Center - Carmichael, Carmichael
Mercy San Juan Medical Center, Carmichael
and 10 more

RecruitingHealthy volunteers welcome

Ages 18 and older · All sexes · Updated Nov 4, 2026 · NCT07283939

A Study of LY4337713 in Participants With FAP-Positive Solid Tumors

Hoag Memorial Hospital Presbyterian, Newport Beach
Stanford University Medical Center, Stanford

RecruitingPhase 1

Ages 18 and older · All sexes · Updated Nov 4, 2026 · NCT07213791

A Study of LY4257496 in Participants With Cancer (OMNIRAY)

City of Hope, Duarte
University of California, Los Angeles (UCLA), Santa Monica
Stanford University Medical Center, Stanford

RecruitingPhase 1

Ages 18 and older · All sexes · Updated Nov 4, 2026 · NCT07114601

Distance-Based Exercise to Preserve Function and Prevent Disability

Kaiser Permanente Dublin, Dublin
Kaiser Permanente-Fremont, Fremont
Kaiser Permanente Fresno Orchard Plaza, Fresno
and 10 more

Recruiting

Ages 18 and older · All sexes · Updated Nov 4, 2026 · NCT07059884

A Study to Learn More About How Well Treatment With Sevabertinib (BAY 2927088) Tablets Works and How Safe it is in Participants Who Have a Solid Tumor With Mutations of the Human Epidermal Growth Factor Receptor 2 (HER2)

City of Hope - Duarte Cancer Center, Duarte

RecruitingPhase 2

Ages 18 and older · All sexes · Updated Nov 4, 2026 · NCT06760819

Intraoperative Imaging of Gastrointestinal Malignancies Using Pafolacianine (CYTALUX™)

Cedars-Sinai Medical Center, Los Angeles

RecruitingPhase 4

Ages 18 and older · All sexes · Updated Nov 2, 2026 · NCT07124351

A Study of Bispecific Antibody MCLA-158 in Patients With Advanced Solid Tumors

UCSD, La Jolla
Sharp Healthcare, San Diego

RecruitingPhase 1/2

Ages 18 and older · All sexes · Updated Nov 2, 2026 · NCT03526835

Lead-212 PSV359 Therapy for Patients With Solid Tumors

VA Greater Los Angeles Healthcare System, Los Angeles
UCLA Department of Medicine - Hematology/Oncology, Los Angeles

RecruitingPhase 1/2

Ages 18 to 90 · All sexes · Updated Oct 28, 2026 · NCT06710756

A Study of MGC026 in Participants With Advanced Solid Tumors

The Angeles Clinic and Research Institute, Los Angeles

RecruitingPhase 1

Ages 18 and older · All sexes · Updated Oct 28, 2026 · NCT06242470

A Study of HER3-DXd in Subjects With Locally Advanced or Metastatic Solid Tumors

City of Hope, Duarte

RecruitingPhase 2

Ages 18 and older · All sexes · Updated Oct 26, 2026 · NCT06172478

Phase 1/2 Study of BHB810 in Advanced Gastric and GEJ Adenocarcinoma

City of Hope Duarte, Duarte
University of California at Los Angeles, Santa Monica

RecruitingPhase 1/2

Ages 18 and older · All sexes · Updated Oct 20, 2026 · NCT07529808

Using 18F-FAPI PET to Detect Metastatic Disease in Patients That Have Gastric or Esophageal Cancer.

Helios CR Inc./RadNet, Cerritos
City of Hope National Cancer Center, Duarte
Hoag Memorial Hospital, Irvine
and 2 more

RecruitingPhase 3

Ages 18 and older · All sexes · Updated Oct 19, 2026 · NCT07217704

Sonesitatug Vedotin in Combination With Capecitabine With or Without Rilvegostomig in Participants With Advanced or Metastatic Gastric, Gastroesophageal Junction, or Esophageal Adenocarcinoma Expressing Claudin18.2

Research Site, Duarte
Research Site, Fountain Valley
Research Site, Fullerton
and 6 more

RecruitingPhase 3

Ages 18 and older · All sexes · Updated Oct 16, 2026 · NCT07431281

Open Label Study to Evaluate BL-M07D1 in HER2 Expressing Malignant Solid Tumors

City of Hope, Duarte
START - Los Angeles, Los Angeles
Cedars Sinai, Los Angeles
and 1 more

RecruitingPhase 1

Ages 18 and older · All sexes · Updated Oct 13, 2026 · NCT06293898

Symbiotic-GI-16: A Study to Learn About the Study Medicine Called PF-08634404 in Combination With Chemotherapy in Gastroesophageal Cancer

UCLA Hematology/Oncology - Atascadero, Atascadero
UCLA Hematology/Oncology - Burbank, Burbank
UCLA Hematology/Oncology - Encino, Encino
and 7 more

RecruitingPhase 2/3

Ages 18 and older · All sexes · Updated Oct 13, 2026 · NCT07392892

A Clinical Study to Test if an Investigational Treatment Called BNT326 is Safe and Potentially Beneficial When Used Alone or in Combination With Other Investigational Treatments Such as BNT327, for People With Advanced Malignant Tumors

University of California San Francisco, San Francisco

RecruitingPhase 1/2

Ages 18 and older · All sexes · Updated Oct 9, 2026 · NCT07070232

A Study of TRK-950 When Used in Combination With Ramucirumab and Paclitaxel in Patients With Gastric Cancer

City of Hope, Duarte
City of Hope at Orange County Lennar Foundation Cancer Center, Irvine
University of California, Los Angeles, Santa Monica

RecruitingPhase 2

Ages 18 and older · All sexes · Updated Oct 8, 2026 · NCT06038578

AZD0901 in Participants With Advanced Solid Tumours Expressing Claudin18.2

Research Site, Orange
Research Site, Palo Alto
Research Site, Santa Rosa

RecruitingPhase 2

Ages 18 and older · All sexes · Updated Sep 30, 2026 · NCT06219941

Phase 3 Study of Cadonilimab Combined With Chemotherapy vs Chemotherapy in Combination With or Without Nivolumab for the 1L Treatment of Participants With HER2-negative, Previously Untreated, Unresectable or Metastatic Gastric/GEJ Adenocarcinoma

UCLA Health, Los Angeles

RecruitingPhase 3

Ages 18 and older · All sexes · Updated Sep 29, 2026 · NCT07700979

IKS014 in Advanced Solid Tumors That Express HER2

Hoag Memorial Hospital Presbyterian, Newport Beach

RecruitingPhase 1

Ages 18 and older · All sexes · Updated Sep 28, 2026 · NCT05872295

Safety and Efficacy of NEO212 in Patients With Astrocytoma IDH-mutant, Glioblastoma IDH-wildtype or Brain Metastasis

Precision NextGen Oncology, Beverly Hills
OPN Healthcare, Inc, Glendale
University of Southern California, Los Angeles

RecruitingPhase 1/2

Ages 18 and older · All sexes · Updated Sep 24, 2026 · NCT06047379

Study of Dato-DXd as Monotherapy and in Combination With Anti-cancer Agents in Patients With Advanced Solid Tumours (TROPION-PanTumor03)

Research Site, Los Angeles
Research Site, Santa Rosa

RecruitingPhase 2

Ages 18 to 130 · All sexes · Updated Sep 23, 2026 · NCT05489211

Study of Elironrasib and Daraxonrasib as Monotherapies and Combination Therapy in Participants With Advanced KRAS G12C Mutant Solid Tumors

UC IRVINE Health, Orange
UC Davis Comprehensive Cancer Center, Sacramento
Stanford Cancer Institute, Stanford

RecruitingPhase 1/2

Ages 18 and older · All sexes · Updated Sep 22, 2026 · NCT06128551

Neratinib and Fam-Trastuzumab Deruxtecan in Advanced Gastro-esophageal Cancer Patients

Stanford Cancer Center, Palo Alto

RecruitingPhase 1

Ages 18 and older · All sexes · Updated Sep 21, 2026 · NCT05274048

A Phase 1/1b Study of IAM1363 in HER2 Cancers

UCSD Moores Cancer Center, La Jolla
USC Norris Comprehensive Cancer Center, Los Angeles

RecruitingPhase 1

Ages 18 and older · All sexes · Updated Sep 9, 2026 · NCT06253871

Ph II Intraperitoneal Paclitaxel + System Therapy in GI Ca w/Peritoneal Carcinomatosis (STOPGAP-B)

Chao Family Comprehensive Cancer Center, University of California, Irvine, Orange

RecruitingPhase 2

Ages 18 and older · All sexes · Updated Aug 31, 2026 · NCT07795749

Ivonescimab in Comb. With FOLFOX in Advanced HER2 Neg. GEA

UCLA, Santa Monica

RecruitingPhase 2

Ages 18 and older · All sexes · Updated Aug 28, 2026 · NCT07070466

A Study of STRO-004 in Adults With Refractory/Recurrent Metastatic Cancer

UC San Diego Moores Cancer Center, San Diego

RecruitingPhase 1

Ages 18 and older · All sexes · Updated Aug 27, 2026 · NCT07227168

PIPAC for the Treatment of Peritoneal Carcinomatosis in Patients With Ovarian, Uterine, Appendiceal, Colorectal, or Gastric Cancer

City of Hope Medical Center, Duarte

RecruitingPhase 1

Ages 18 and older · All sexes · Updated Aug 26, 2026 · NCT04329494

Patient-Derived Xenografts to Reduce Cancer Health Disparities

UC Irvine Health/Chao Family Comprehensive Cancer Center, Orange
University of California Davis Comprehensive Cancer Center, Sacramento

RecruitingObservational study

Ages 21 to 100 · All sexes · Updated Aug 20, 2026 · NCT04410302

Radiation Therapy for the Treatment of Metastatic Gastrointestinal Cancers

University of California, San Francisco, San Francisco
John Muir Medical Center-Walnut Creek, Walnut Creek

Recruiting

Ages 18 and older · All sexes · Updated Aug 14, 2026 · NCT04221893

A Study of MRG007 (ARR-217) in Patients With Advanced Solid Tumors

ULCA, Los Angeles
UCSF, San Francisco

RecruitingPhase 1

Ages 18 and older · All sexes · Updated Aug 13, 2026 · NCT07066657

Study of Orally Administered MOMA-341 in Participants With Advanced or Metastatic Solid Tumors

Investigative Site #101, San Diego

RecruitingPhase 1

Ages 18 and older · All sexes · Updated Jul 23, 2026 · NCT06974110

From ClinicalTrials.gov, data retrieved Nov 15, 2026. Each study sets its own eligibility; the study team decides who can join.