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Syphilis clinical trials recruiting in the U.S.
11 studies for Syphilis are recruiting participants at sites across the United States.
Syphilis is a sexually transmitted disease. It causes sores on the genitals, rectum, or mouth. Read about testing, prevention, and treatment.
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Recently updated studies
A Seek, Test, and Treat Intervention to Reduce Chlamydia Trachomatis Disparities
RecruitingHealthy volunteers welcome
Ages 15 to 26 ยท All sexes ยท Updated Sep 21, 2026 ยท NCT06428643This Study Evaluates the ALPCO Syphilis-T and Syphilis-NT CLIA Kits for Detecting Syphilis Antibodies in Serum and Plasma. Samples From At-risk, HIV-positive, Pregnant, and Healthy Individuals Will Assess Assay Performance Versus Established Comparator Tests.
RecruitingObservational studyHealthy volunteers welcome
Ages 13 and older ยท All sexes ยท Updated Sep 16, 2026 ยท NCT07089836Improving Maternal and Child Health Through Point-of-care STI Testing
RecruitingHealthy volunteers welcome
All ages ยท Women ยท Updated Aug 19, 2026 ยท NCT07290439Rapid HIV, Hep C, and Syphilis Screening in a Rural Street Medicine Clinic
RecruitingObservational studyHealthy volunteers welcome
Ages 18 and older ยท All sexes ยท Updated Aug 13, 2026 ยท NCT07317687Study of Ceftriaxone and Benzathine Penicillin G During Pregnancy
RecruitingObservational study
All ages ยท Women ยท Updated Aug 6, 2026 ยท NCT07207876Doxycycline Prophylaxis for Prevention of Sexually Transmitted Infections
RecruitingPhase 4
Ages 13 to 29 ยท Women ยท Updated May 15, 2026 ยท NCT06738407Offering Routine and Rapid Point of Care (POC) Syphilis Testing in Pregnant Patients Presenting to the Emergency Department
Recruiting
Ages 18 to 50 ยท Women ยท Updated May 6, 2026 ยท NCT06645106Cefixime Clinical Trial
RecruitingPhase 3
Ages 18 and older ยท All sexes ยท Updated May 4, 2026 ยท NCT04958122Modernizing Perinatal Syphilis Testing
Recruiting
Up to age 45 ยท All sexes ยท Updated Nov 3, 2025 ยท NCT06082453Daily Doxycycline for Early Syphillis
RecruitingPhase 2
Ages 18 and older ยท All sexes ยท Updated Jun 25, 2025 ยท NCT06683638LIMIT Trial - Lidocaine With Intramuscular Injection of Benzathine Penicillin G for Treponema Pallidum Treatment
RecruitingPhase 3Healthy volunteers welcome
Ages 18 and older ยท All sexes ยท Updated Mar 25, 2025 ยท NCT06391125From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.