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Gastrointestinal Stromal Tumors clinical trials recruiting in the U.S.

19 studies for Gastrointestinal Stromal Tumors are recruiting participants at sites across the United States.

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Recently updated studies

Surgery in Gastrointestinal Stromal Tumors (GISTs) for Treatment, Tumor Modeling, and Genomic Analysis

RecruitingObservational study
Ages 6 and older · All sexes · Updated Oct 2, 2026 · NCT04557969

DESTINY-PANTUMOUR04

RecruitingObservational study
Ages 18 to 130 · All sexes · Updated Sep 25, 2026 · NCT07124000

A Study of IDRX-42 (GSK6042981) Versus (vs) Sunitinib in Participants With Gastrointestinal Stromal Tumors After Imatinib Therapy

RecruitingPhase 3
Ages 18 and older · All sexes · Updated Sep 25, 2026 · NCT07218926

Imatinib TDM in GIST

RecruitingPhase 2
Ages 18 and older · All sexes · Updated Aug 31, 2026 · NCT05493215

KQB198 in Combination With Imatinib in Participants With Advanced/Metastatic GIST in 1st Line Setting (SynerGIST-1st Line)

RecruitingPhase 2
Ages 18 and older · All sexes · Updated Aug 10, 2026 · NCT07406633

A Study to Assess the Efficacy and Safety of FORE8394 in Participants With Cancer Harboring BRAF Alterations

RecruitingPhase 2
Ages 8 and older · All sexes · Updated Jul 27, 2026 · NCT05503797

A Study of Inlexisertib (DCC-3116) in Combination With Anticancer Therapies in Participants With Advanced Malignancies

RecruitingPhase 1/2
Ages 18 and older · All sexes · Updated Jul 23, 2026 · NCT05957367

LRG GIST Patient Registry

RecruitingObservational study
All ages · All sexes · Updated Jul 13, 2026 · NCT07697248

Integrated Cancer Repository for Cancer Research

RecruitingObservational studyHealthy volunteers welcome
Ages 19 to 110 · All sexes · Updated Jun 29, 2026 · NCT02012699

(Peak) A Phase 3 Randomized Trial of CGT9486+Sunitinib vs. Sunitinib in Subjects With Gastrointestinal Stromal Tumors

RecruitingPhase 3
Ages 18 and older · All sexes · Updated Jun 16, 2026 · NCT05208047

Preoperative Imatinib and Fampridine in KIT Mutant Gastrointestinal Stromal Tumor

RecruitingPhase 1
Ages 18 and older · All sexes · Updated May 27, 2026 · NCT07171203

PH 2 Pemigatinib in SDH-deficient GIST

RecruitingPhase 2
Ages 18 and older · All sexes · Updated May 22, 2026 · NCT07434843

A Master Protocol to Evaluate DCC-3009 in Gastrointestinal Stromal Tumor (GIST)

RecruitingPhase 1/2
Ages 18 and older · All sexes · Updated Feb 5, 2026 · NCT06630234

A Study of Ziftomenib in Combination With Imatinib in Patients With Advanced Gastrointestinal Stromal Tumors (GIST)

RecruitingPhase 1
Ages 18 and older · All sexes · Updated Feb 5, 2026 · NCT06655246

Clinical & Pathological Studies of Upper Gastrointestinal Carcinoma

RecruitingObservational study
Ages 18 and older · All sexes · Updated Dec 18, 2025 · NCT01048281

A Study of the c-Kit Specific Antibody-Drug Conjugate NN3201 for Advanced and/or Metastatic Solid Tumors Known to Express c-Kit

RecruitingPhase 1
Ages 18 and older · All sexes · Updated Sep 23, 2025 · NCT06805825

ctDNA-Guided Sunitinib And Regorafenib Therapy for GIST

RecruitingPhase 2
Ages 18 and older · All sexes · Updated Sep 9, 2025 · NCT05366816

From ClinicalTrials.gov, data retrieved Oct 5, 2026. Each study sets its own eligibility; the study team decides who can join.