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Oropharyngeal Cancer clinical trials recruiting in the U.S.
52 studies for Oropharyngeal Cancer are recruiting participants at sites across the United States.
Cities with the most studies
- Edison, NJ8 studies
- Atlanta, GA8 studies
- Chicago, IL7 studies
- New York City, NY6 studies
- Queens, NY5 studies
- Los Angeles, CA5 studies
- Philadelphia, PA5 studies
- Pittsburgh, PA5 studies
- Milwaukee, WI5 studies
- St. Louis, MO5 studies
- Omaha, NE5 studies
- Kansas City, MO5 studies
- Houston, TX5 studies
- Tampa, FL5 studies
- Rochester, MN4 studies
- Staten Island, NY4 studies
- Greenburgh, NY4 studies
- East Norwalk, CT4 studies
- Ann Arbor, MI4 studies
- Overland Park, KS4 studies
- Kansas City, KS4 studies
- Detroit, MI4 studies
- Naperville, IL4 studies
- Durham, NC4 studies
- Washington, DC4 studies
- Richmond, VA4 studies
- Baltimore, MD4 studies
- New Rochelle, NY3 studies
- Portland, OR3 studies
- West Bend, WI3 studies
- Champaign, IL3 studies
- Oklahoma City, OK3 studies
- Charleston, IL3 studies
- Danville, IL3 studies
- Des Moines, IA3 studies
- Stevens Point, WI3 studies
- North Peoria, IL3 studies
- Bloomington, IL3 studies
- Aurora, IL3 studies
- Jacksonville, FL3 studies
By state
- Arizona4 studies
- California9 studies
- Colorado4 studies
- District of Columbia3 studies
- Florida12 studies
- Georgia8 studies
- Illinois8 studies
- Iowa5 studies
- Kansas5 studies
- Kentucky3 studies
- Maryland7 studies
- Massachusetts4 studies
- Michigan6 studies
- Minnesota6 studies
- Missouri9 studies
- Nebraska5 studies
- New Hampshire3 studies
- New Jersey8 studies
- New York11 studies
- North Carolina6 studies
- North Dakota3 studies
- Ohio8 studies
- Oklahoma4 studies
- Oregon3 studies
- Pennsylvania10 studies
- South Carolina3 studies
- Tennessee3 studies
- Texas6 studies
- Vermont3 studies
- Virginia4 studies
- Wisconsin6 studies
Recently updated studies
De-Escalated Adjuvant and Definitive Radiation Therapy Informed by DART 2.0 ctHPV-DNA
RecruitingPhase 2
Ages 18 and older · All sexes · Updated Oct 1, 2026 · NCT05541016Methotrexate, Erlotinib, and Celecoxib for the Treatment of Recurrent/Metastatic Head and Neck Cancer in a Rural Midwest United States Population
RecruitingPhase 2
Ages 18 and older · All sexes · Updated Oct 1, 2026 · NCT06997068Testing the Addition of Chemotherapy or Chemo-Immunotherapy to the Usual Surgery for Advanced Head and Neck Cancer
RecruitingPhase 2
Ages 18 and older · All sexes · Updated Sep 29, 2026 · NCT07195734Dose Adjusted Chemoradiotherapy in HPV-Associated Oropharynx Cancer of the Elderly
Recruiting
Ages 65 to 99 · All sexes · Updated Sep 29, 2026 · NCT06309225BiCaZO: A Study Combining Two Immunotherapies (Cabozantinib and Nivolumab) to Treat Patients With Advanced Melanoma or Squamous Cell Head and Neck Cancer, an immunoMATCH Pilot Study
RecruitingPhase 2
Ages 18 and older · All sexes · Updated Sep 25, 2026 · NCT05136196Biomarker Approach to Screening for the Early Detection of HPV-related Oropharyngeal Cancer (BASH OPC)
RecruitingObservational studyHealthy volunteers welcome
Ages 18 and older · All sexes · Updated Sep 23, 2026 · NCT06305676Testing the Addition of Ipatasertib to Usual Chemotherapy and Radiation for Head and Neck Cancer
RecruitingPhase 1
Ages 18 and older · All sexes · Updated Sep 22, 2026 · NCT05172245Multidimensional and Multimodal Profiling of Oropharyngeal Carcinoma
RecruitingObservational study
Ages 18 and older · All sexes · Updated Sep 15, 2026 · NCT05880797Testing the Addition of an Anti-Cancer Drug, Camonsertib, to Radiation Therapy for Recurrent Head and Neck Squamous Cell Carcinoma
RecruitingPhase 1
Ages 18 and older · All sexes · Updated Sep 3, 2026 · NCT07156227Testing the Addition of the Drug BMX-001, a Radioprotector, or a Placebo to the Usual Chemoradiation Therapy for Patients With Head and Neck Cancer
RecruitingPhase 2
Ages 18 and older · All sexes · Updated Aug 17, 2026 · NCT06532279Comparing Radiation Plus Cetuximab to Radiation Plus Chemotherapy in People With Head and Neck Cancer Who Cannot Receive Cisplatin
RecruitingPhase 3
Ages 18 and older · All sexes · Updated Aug 17, 2026 · NCT07441681Risk-adapted Therapy in HPV+ Oropharyngeal Cancer Using Circulating Tumor (ct)HPV DNA Profile - The ReACT Study
RecruitingPhase 2
Ages 22 and older · All sexes · Updated Aug 5, 2026 · NCT04900623Pre-operative Atezolizumab in Patients With Resectable, Human Papillomavirus Related Oropharyngeal Carcinoma
RecruitingPhase 2
Ages 18 and older · All sexes · Updated Aug 5, 2026 · NCT06254911Using CircuLating Tumor DNA to Risk Adapt Post-Operative Therapy for HPV-associated Oropharyngeal Cancer
RecruitingPhase 2
Ages 18 and older · All sexes · Updated Aug 5, 2026 · NCT06445114Study of INBRX-106 and INBRX-106 in Combination With Pembrolizumab (Keytruda®) in Subjects With Locally Advanced or Metastatic Solid Tumors (Hexavalent OX40 Agonist)
RecruitingPhase 1/2
Ages 18 and older · All sexes · Updated Jul 29, 2026 · NCT04198766The Minimalist Trial-2
RecruitingPhase 2
Ages 18 and older · All sexes · Updated Jul 24, 2026 · NCT06702033Transoral Surgical Resection Followed by De-escalated Adjuvant IMRT in Resectable p16+ Locally Advanced Oropharynx Cancer
RecruitingPhase 2
Ages 18 and older · All sexes · Updated Jul 21, 2026 · NCT05388773Remote Audiometry to Monitor for Treatment-Related Hearing Loss in Patients With H&N SCC Receiving Cisplatin and/or Radiation
Recruiting
Ages 18 and older · All sexes · Updated Jul 16, 2026 · NCT06662058pBI-11 & TA-HPV (With Pembrolizumab as Treatment for Patients w/Advanced, PD-L1 CPS≥1, hrHPV+ Oropharyngeal Cancer
RecruitingPhase 2
Ages 18 and older · All sexes · Updated Jul 15, 2026 · NCT05799144Association Between Health Care Provider (HCP)-Assessed ECOG Performance Status (PS) and Overall Survival, and Objectively Measure of Physical Activity (PA) Levels in Advance-cancer Patients"
Recruiting
Ages 18 and older · All sexes · Updated Jul 15, 2026 · NCT01365169Evaluating a Decreased Dose of Radiation Therapy to the Elective Neck for the Treatment of HPV-Related Oropharyngeal Cancer, ENLIGHT Trial
RecruitingPhase 2
Ages 18 and older · All sexes · Updated Jul 14, 2026 · NCT07178301SPECT-CT Guided ELEctive Contralateral Neck Treatment for Patients With Lateralized Oropharyngeal Cancer
RecruitingPhase 3
Ages 18 and older · All sexes · Updated Jul 14, 2026 · NCT05451004Integrated Cancer Repository for Cancer Research
RecruitingObservational studyHealthy volunteers welcome
Ages 19 to 110 · All sexes · Updated Jun 29, 2026 · NCT02012699High Dose Steroid Therapy (Prednisone or Methylprednisolone) for the Improvement of Symptoms of Late Radiation-Associated Lower Cranial Neuropathy in Oropharyngeal Cancer Survivors
RecruitingPhase 1/2
Ages 18 and older · All sexes · Updated Jun 26, 2026 · NCT04151082E7 TCR-T Cell Immunotherapy for Human Papillomavirus (HPV) Associated Cancers
RecruitingPhase 2
Ages 18 and older · All sexes · Updated Jun 12, 2026 · NCT05686226From ClinicalTrials.gov, data retrieved Oct 5, 2026. Each study sets its own eligibility; the study team decides who can join.