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Oropharyngeal Cancer clinical trials recruiting in the U.S.

52 studies for Oropharyngeal Cancer are recruiting participants at sites across the United States.

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Recently updated studies

De-Escalated Adjuvant and Definitive Radiation Therapy Informed by DART 2.0 ctHPV-DNA

RecruitingPhase 2
Ages 18 and older · All sexes · Updated Oct 1, 2026 · NCT05541016

Testing the Addition of Chemotherapy or Chemo-Immunotherapy to the Usual Surgery for Advanced Head and Neck Cancer

RecruitingPhase 2
Ages 18 and older · All sexes · Updated Sep 29, 2026 · NCT07195734

Dose Adjusted Chemoradiotherapy in HPV-Associated Oropharynx Cancer of the Elderly

Recruiting
Ages 65 to 99 · All sexes · Updated Sep 29, 2026 · NCT06309225

Biomarker Approach to Screening for the Early Detection of HPV-related Oropharyngeal Cancer (BASH OPC)

RecruitingObservational studyHealthy volunteers welcome
Ages 18 and older · All sexes · Updated Sep 23, 2026 · NCT06305676

Testing the Addition of Ipatasertib to Usual Chemotherapy and Radiation for Head and Neck Cancer

RecruitingPhase 1
Ages 18 and older · All sexes · Updated Sep 22, 2026 · NCT05172245

Multidimensional and Multimodal Profiling of Oropharyngeal Carcinoma

RecruitingObservational study
Ages 18 and older · All sexes · Updated Sep 15, 2026 · NCT05880797

Risk-adapted Therapy in HPV+ Oropharyngeal Cancer Using Circulating Tumor (ct)HPV DNA Profile - The ReACT Study

RecruitingPhase 2
Ages 22 and older · All sexes · Updated Aug 5, 2026 · NCT04900623

Pre-operative Atezolizumab in Patients With Resectable, Human Papillomavirus Related Oropharyngeal Carcinoma

RecruitingPhase 2
Ages 18 and older · All sexes · Updated Aug 5, 2026 · NCT06254911

Using CircuLating Tumor DNA to Risk Adapt Post-Operative Therapy for HPV-associated Oropharyngeal Cancer

RecruitingPhase 2
Ages 18 and older · All sexes · Updated Aug 5, 2026 · NCT06445114

The Minimalist Trial-2

RecruitingPhase 2
Ages 18 and older · All sexes · Updated Jul 24, 2026 · NCT06702033

Transoral Surgical Resection Followed by De-escalated Adjuvant IMRT in Resectable p16+ Locally Advanced Oropharynx Cancer

RecruitingPhase 2
Ages 18 and older · All sexes · Updated Jul 21, 2026 · NCT05388773

pBI-11 & TA-HPV (With Pembrolizumab as Treatment for Patients w/Advanced, PD-L1 CPS≥1, hrHPV+ Oropharyngeal Cancer

RecruitingPhase 2
Ages 18 and older · All sexes · Updated Jul 15, 2026 · NCT05799144

SPECT-CT Guided ELEctive Contralateral Neck Treatment for Patients With Lateralized Oropharyngeal Cancer

RecruitingPhase 3
Ages 18 and older · All sexes · Updated Jul 14, 2026 · NCT05451004

Integrated Cancer Repository for Cancer Research

RecruitingObservational studyHealthy volunteers welcome
Ages 19 to 110 · All sexes · Updated Jun 29, 2026 · NCT02012699

E7 TCR-T Cell Immunotherapy for Human Papillomavirus (HPV) Associated Cancers

RecruitingPhase 2
Ages 18 and older · All sexes · Updated Jun 12, 2026 · NCT05686226

From ClinicalTrials.gov, data retrieved Oct 5, 2026. Each study sets its own eligibility; the study team decides who can join.