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Monoclonal Gammopathy of Undetermined Significance clinical trials recruiting in the U.S.
12 studies for Monoclonal Gammopathy of Undetermined Significance are recruiting participants at sites across the United States.
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Recently updated studies
A Study of a Plant-Based Diet and Dietary Supplements in People With Smoldering Multiple Myeloma (SMM) or Monoclonal Gammopathy of Undetermined Significance (MGUS)
Recruiting
Ages 18 and older · All sexes · Updated Oct 5, 2026 · NCT06055894CHAAMP (CHArlotte Advocate MGUS Project) Internal Pilot Study
RecruitingObservational studyHealthy volunteers welcome
Ages 30 and older · All sexes · Updated Jul 13, 2026 · NCT06644625A Proof-of-Concept Study to Learn Whether Linvoseltamab Can Eliminate Abnormal Plasma Cells That May Lead to Multiple Myeloma in Adult Patients With High-Risk Monoclonal Gammopathy of Undetermined Significance or Non-High-Risk Smoldering Multiple Myeloma
RecruitingPhase 2
Ages 18 and older · All sexes · Updated Jul 8, 2026 · NCT06140524Study of MGUS, Smoldering Myeloma, Early MDS and CLL to Assess Molecular Events of Progression and Clinical Outcome
RecruitingObservational study
Ages 18 and older · All sexes · Updated May 7, 2026 · NCT02269592FAST-M: Prolonged Overnight Fasting and Mediterranean Dietary Intervention for Patients With Multiple Myeloma or Its Precursor Disease
Recruiting
Ages 18 and older · All sexes · Updated May 1, 2026 · NCT07446777Observational Prospective Research Study In Monoclonal Gammopathies leadINg to Myeloma
RecruitingObservational study
Ages 18 and older · All sexes · Updated Apr 21, 2026 · NCT02726750A Study Comparing a Plant-Based Diet With Supplements and Placebo in People With Monoclonal Gammopathy of Undetermined Significance (MGUS) or Smoldering Multiple Myeloma (SMM)
Recruiting
Ages 18 and older · All sexes · Updated Apr 16, 2026 · NCT05640843Quality of Life in Patients With Asymptomatic Monoclonal Gammopathies
RecruitingObservational study
Ages 18 and older · All sexes · Updated Apr 15, 2026 · NCT05136807Two Biologically and Clinically Distinct Entities: Progressive Versus Stable Multiple Myeloma (MM) Precursor Conditions
RecruitingObservational study
Ages 18 and older · All sexes · Updated Apr 9, 2026 · NCT05361694Ohio State University Multiple Myeloma and Amyloidosis Data Registry and Sample Resource
RecruitingObservational study
Ages 18 and older · All sexes · Updated Mar 23, 2026 · NCT01408225The Indiana Myeloma Registry
RecruitingObservational study
Ages 18 and older · All sexes · Updated Nov 10, 2025 · NCT03616483Sleep Apnea in Patients With MGUS and MM
RecruitingObservational study
Ages 18 to 99 · All sexes · Updated Nov 10, 2025 · NCT04114084From ClinicalTrials.gov, data retrieved Oct 6, 2026. Each study sets its own eligibility; the study team decides who can join.