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Establishing a Tumor Bank in Families With Multiple Lymphoproliferative Malignancies

RecruitingObservational study

Establishing a Tumor Bank and Initial Analysis of Germline and Tumor-Related Genetic Alterations in Families With Multiple Lymphoproliferative Malignancies

Who can join

Ages 18 and older · All sexes

Full eligibility criteria
Inclusion Criteria:

* Any individual diagnosed with non-Hodgkin's lymphoma or Hodgkin's disease or chronic lymphocytic leukemia (CLL), who has a 1st degree relative (parent, sibling or child) with a lymphoproliferative disorder; or families in which the individual has a lymphoproliferative disorder, and an unusual clustering of frequent or premature solid tumors is also observed.
* Family members of the individual, either affected or unaffected with lymphoma, who are contacted by the individual and agree to participate in the study.
* Deceased family members may be included in the study. Public records such as death certificates may be used to confirm the history. Consent for medical records or tissue blocks will be obtained from the deceased family member's next of kin. The hierarchy of relatives defined as next of kin is spouse, offspring, parents and siblings. Archived tissue samples may be used for genetic research.
* Age \> 18 years

Exclusion Criteria:

* Subjects without a family history of lymphoma

About the study

The purpose of this study is to investigate possible genetic factors that contribute to the development of lymphomas. The databank will be used to determine whether familial lymphomas have unique genetic characteristics different from sporadic lymphomas and to attempt to identify a gene that confers an increased risk of lymphoma.

Sponsor: Dana-Farber Cancer Institute · Participants: 1,500 · Started: Aug 9, 2004

Contact the study team

Official record on ClinicalTrials.gov — NCT00131014

Locations in the U.S.

MassachusettsDana-Farber Cancer Institute, Boston

Conditions

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.