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High Risk Breast Clinic: Protocol for Women at Increased Risk for Developing Breast Cancer

Who can join

Ages 30 to 65 · Women · Healthy volunteers welcome

Inclusion Criteria:

* women with at least 2 times the normal risk of developing breast cancer
* between the ages of 30-65 (or within 10 years of youngest age at diagnosis in first degree relative)
* greater than six months from ingestion of antihormonal therapy
* greater than 1 year from pregnancy, lactation, or chemotherapy
* willing to have a mammogram within six months prior to RPFNA
* willing to discontinue NSAIDS or herbal supplements
* willing to have blood drawn

Exclusion Criteria:

* no metastatic malignancy of any kind
* no breast implants or tram flap reconstructions
* no radiation to both breasts
* no women who have a current mammogram or clinical breast exam suspicious for cancer

About the study

The overall goal of this project is to develop an integrative system of breast cancer risk assessment based on epidemiologic and biologic risk variables, as well as to develop or refine risk biomarkers which may be useful in predicting and monitoring response to prevention interventions.

Sponsor: Carol Fabian, MD · Participants: 3,000 · Started: 1989-08

Contact the study team

• Bruce Kimler, Ph.D. · Phone: 913-588-4523

Official record on ClinicalTrials.gov — NCT00291096

Locations in the U.S.

Conditions

• Breast Cancer

From ClinicalTrials.gov, data retrieved Sep 29, 2026. Each study sets its own eligibility; the study team decides who can join.