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Effect of Neoadjuvant or Adjuvant Systemic Therapy on Breast Cancers, Bone Marrow Cancer Cells, and Circulating Cancer Cells

Who can join

Ages 18 and older · All sexes

Inclusion Criteria:

* Recently diagnosed with clinical stage II, III, or IV breast cancer
* Planning to undergo neoadjuvant or adjuvant systemic therapy; patients who have already completed neoadjuvant systemic therapy are also eligible
* Must be \>= 18 years of age
* If female, must not be pregnant
* Must not have Hepatitis B, C, or HIV
* Must be willing and able to sign informed consent document

About the study

The main purpose of this study is to compare genetic markers present on tumor cells before and after chemotherapy.

What is being tested

• Peripheral blood draw (procedure)
• Breast tissue collection (procedure)
• Bone marrow biopsy (procedure)

Sponsor: Washington University School of Medicine · Participants: 300 · Started: Sep 14, 2005

Contact the study team

• Rebecca Aft, MD, PhD · Phone: 314-747-0063

Official record on ClinicalTrials.gov — NCT00353483

Locations in the U.S.

Conditions

• Breast Cancer

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.