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Identifying Genetic Causes of IC/BPS

Genetic Studies in Interstitial Cystitis/Bladder Pain Syndrome (IC/BPS)

Who can join

Ages 1 and older · All sexes

Inclusion Criteria:

* Diagnosis of IC/BPS
* Males and females of any age
* Urinary frequency - more than 1X/hour, and/or
* Dysuria, and/or
* Pelvic, suprapubic, or abdominal pain - for 3 months or longer
* Nocturia
* Normal urinary stream (by history)
* No evidence of active bacterial UTI (no pyuria \& negative urinary culture for last 3 months)
* First degree relative of someone with above symptoms

Exclusion Criteria:

* Major structural/anatomical urinary tract abnormalities by ultrasound
* Underlying inborn conditions affecting the urinary tract
* Surgery/chemotherapy affected pelvic area
* GI or GU cancers
* Severe Constipation in children only

About the study

Interstitial cystitis (IC), also called Bladder Pain syndrome (BPS) is a common condition with no known cause or cure. Twin studies and family accounts have suggested that the condition may be genetic or passed down (inherited) from one generation to another.

In this study, the investigators are collecting genetic material via blood or saliva and medical information from families in North America in an attempt to identify genetic factors that may cause IC/BPS. The investigators are enrolling inviduals with IC/BPS and their family members (family members with and without IC like symptoms). Travel to Boston not required.

Sponsor: Boston Children's Hospital · Participants: 1,000 · Started: Jan 15, 2006

Contact the study team

• Elicia A Estrella, MS, LCGC · Phone: 617-919-4552

Official record on ClinicalTrials.gov — NCT00389142

Locations in the U.S.

Conditions

• Interstitial Cystitis
• Pelvic Pain

From ClinicalTrials.gov, data retrieved Oct 1, 2026. Each study sets its own eligibility; the study team decides who can join.