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International Pediatric Adrenocortical Tumor Registry

Who can join

Up to age 21 · All sexes

STRATIFICATION ASSIGNMENT:

* Stratum A: participant suspected or confirmed diagnosis of adrenocortical tumor (ACT)
* Stratum R: relative of participant with ACT and TP53 mutation who has diagnosis of malignancy
* Stratum P: biological parent of participant with ACT

Inclusion Criteria - Stratum A (participant with ACT):

* Age ≤ 21 years old at diagnosis
* Suspected or confirmed diagnosis of adrenocortical tumor (adenoma, carcinoma or undefined histology).
* Signed informed consent

Inclusion Criteria - Stratum R (relative):

* Any age
* Diagnosis of malignant tumor
* Signed informed consent

Inclusion Criteria - Stratum P (parent):

* Biological parent of Stratum A participant

About the study

This study aims to collect demographic and medical information including detailed family history of cancer of children and adolescents with adrenocortical tumors in order to learn more about the clinical and epidemiological aspects, treatment modalities, and outcome of patients with this rare disease, worldwide.

In addition, investigators at St. Jude Children's Research Hospital (SJCRH) plan to perform molecular studies of tumor cells aimed to clarify the role of the TP53 gene and other genetic pathways in these tumors. They aim to obtain relevant biological material from participants with adrenocortical tumor (ACT), their biological parents, and relatives for determination of the TP53 germline status, molecular studies of the TP53 gene, and other molecular pathways.

Sponsor: St. Jude Children's Research Hospital · Participants: 9,999 · Started: Oct 1, 2001

Contact the study team

• Raul C Ribeiro, MD · Phone: 866-278-5833

Official record on ClinicalTrials.gov — NCT00700414

Locations in the U.S.

From ClinicalTrials.gov, data retrieved Oct 2, 2026. Each study sets its own eligibility; the study team decides who can join.