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Genetic Variants and Susceptibility to Diseases of Prematurity in Very Low Birth-Weight Infants

Who can join

All ages · All sexes

Inclusion Criteria:

* Infants born weighing less than 1500 grams

Exclusion Criteria:

* Infants born with congenital heart disease (other than patent ductus arteriosus)
* major congenital anomalies of the GI tract, respiratory tract, or kidneys

About the study

The purpose of this study is to determine if sequence variations in genes involved in the development and function of vulnerable organs increases susceptibility to chronic lung disease (CLD) and other diseases affecting premature infants, such as necrotizing enterocolitis (NEC), sepsis, patent ductus arteriosus (PDA) and intraventricular hemorrhage (IVH). The study will also determine whether measurement of certain biomarkers in serum will identify infants who will develop these complications of prematurity. Previous studies from this institution and others have identified genetic variants in some genes, such as toll like receptor genes are associated with higher risk of CLD or NEC. The interaction of these variants with other gene variants that can influence the risk of these diseases remains unclear.

What is being tested

• gene variations (genetic)

Sponsor: Medical College of Wisconsin · Participants: 1,100 · Started: 2006-06

Contact the study team

• G. Ganesh Konduri, MD · Phone: 414.266.6820
• Kathleen M Meskin, BSN · Phone: 414.337.7171

Official record on ClinicalTrials.gov — NCT00710112

Locations in the U.S.

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.