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Genetic Investigations in Spontaneous Coronary Artery Dissection (SCAD)

Who can join

Ages 18 and older · All sexes · Healthy volunteers welcome

Inclusion Criteria:

* Men and women able to give informed consent and complete a 2 page questionnaire
* Diagnosis of one or more episodes of spontaneous coronary artery dissection (SCAD)
* Biological parent of individual with SCAD
* Relative with fibromuscular dysplasia, arterial aneurysm, or arterial dissection

Exclusion Criteria:

* Lack of confirmation of SCAD diagnosis

About the study

The purpose of the research is to identify mutations (defects in the genetic blueprint) that cause spontaneous coronary artery dissection (SCAD), in other words, spontaneous tears in blood vessels that supply the heart.

Some mutations may be inherited (passed on) from a parent without an apparent blood vessel problem while others may develop for the first time in the affected person.

Sponsor: Mayo Clinic · Participants: 2,000 · Started: 2011-05

Contact the study team

• Jake Nemgar · Phone: 5072663180

Official record on ClinicalTrials.gov — NCT01427179

Locations in the U.S.

Conditions

• Spontaneous Coronary Artery Dissection

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.