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Use of Hyperpolarized Xenon Gas for Lung Imaging in Children and Adults

Use of Hyperpolarized 129 Xe MR Lung Imaging in Children and Adults

Who can join

Ages 6 and older · All sexes · Healthy volunteers welcome

Inclusion Criteria:

* Ages 6 and up
* Participant must be able to hold breath for up to 16 seconds

Exclusion Criteria:

* History of heart defect
* Pregnancy or positive pregnancy test
* History of uncontrolled asthma defined for this study as requiring use of rescue inhaler ≥ 2 times in past month
* Symptoms of respiratory infection (loose or productive cough or wheeze), chest tightness, or sinus infection within past week
* Baseline oximetry at MRI visit of less than 95% on room air or less than 95% on a previously prescribed dosage of oxygen delivered by nasal cannula
* Participant is claustrophobic and unable to tolerate the imaging.
* Standard MRI exclusions (metal, implants)

About the study

The goal of this study is to evaluate the usefulness of hyperpolarized (HP) 129Xe (xenon) gas MRI for regional assessment of lung function in a normal population of children and adults and in adults and also in children with respiratory compromise due to a variety of diseases.

What is being tested

• Hyperpolarized 129 Xenon (drug)

Sponsor: Children's Hospital Medical Center, Cincinnati · Participants: 300 · Started: 2014-12

Contact the study team

• Carrie Stevens, BS · Phone: 513-636-9973
• Kelly Thornton, BS · Phone: 513-636-0604

Official record on ClinicalTrials.gov — NCT02272049

Locations in the U.S.

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.