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Triple Negative Breast Cancer and Germline Hereditary Breast and Ovarian Cancer Mutation Carrier Registry

RecruitingObservational studyHealthy volunteers welcome

PROspective Evaluation of GErmline Mutations, Cancer Outcome and Tissue Biomarkers: A Registry for Patients With Triple Negative Breast Cancer and Germline Mutations

Who can join

All ages · All sexes · Healthy volunteers welcome

Full eligibility criteria
Inclusion criteria include:

Triple Negative Breast Cancer

* ER/PR \<10% and HER negative per current ASCO/CAP guidelines
* Stages I-IV
* Any age at diagnosis
* Patient must be within 5 years of diagnosis
* Eligible regardless of genetic testing status
* Genetic testing recommended for patients meeting NCCN and Medicare guidelines

AND/OR

Germline mutation Carriers

* Patients with deleterious or uncertain mutations in HBOC genes (BRCA, PTEN, P53, -PALB2 etc) are eligible regardless of type/site of cancer
* Healthy patients harboring mutations also eligible
* There is no time limit from the time of diagnosis of cancer and enrollment.
* Eligible regardless of personal history of cancer

Exclusion Criteria include:

Triple Negative Breast Cancer -Patient is not within five years of diagnosis

Germline mutation Carriers:

-Patient only carries a HBOC mutation that is classified as "polymorphism" of "favor polymorphism"

About the study

PROGECT is a registry for patients with Triple Negative breast cancer (TNBC) or patients who have an identified germline mutations (such as a mutation on the BRCA1 or BRCA2 genes).

Sponsor: University of Kansas Medical Center · Participants: 3,000 · Started: Mar 22, 2011

Contact the study team

Official record on ClinicalTrials.gov — NCT02302742

Locations in the U.S.

KansasHays Medical Center Dreiling-Schmidt Cancer Institute, Hays
KCCC West, Kansas City
KCCC Overland Park, Overland Park
Overland Park Regional Medical Center, Overland Park
Salina Regional Health Center - Tammy Walker Cancer Center, Salina
The University of Kansas Cancer Center, Westwood
MissouriKCCC - North, Kansas City
KCCC South, Kansas City
Research Medical Center, Kansas City
Universtiy Health, Kansas City
KCCC Lee's Summit, Lee's Summit

Conditions

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.