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Analysis of Prognostic Cell Signaling Factors in Adolescent Idiopathic Scoliosis

Who can join

Ages 10 to 13 · Women

Inclusion Criteria:

* Females aged 10-13 years
* Diagnosed with mild-moderate spine deformity (Cobb angle 15-30 degrees)

Exclusion Criteria:

* Patients with scoliosis other than idiopathic
* Trauma
* Inflammatory disease
* Malignancies
* Diabetes
* History of previous spine surgery

About the study

The purpose of this study is to identify potential markers for curve progression in adolescent idiopathic scoliosis (AIS). Despite its prevalence and impact on child health, the etiology of AIS and molecular mechanisms underlying its development and progression remain poorly understood. Clinical criteria and features cannot adequately predict which children, diagnosed with mild disease, will undergo subsequent curve progression requiring intervention.

The investigators hypothesize that alterations in specific genetic markers will be correlated with the progression of AIS curves over time. Thus, these markers could be used in the future to develop a reliable, inexpensive and relatively non-invasive cell based diagnostic test to (1) predict spinal curve progression in AIS, (2) select patients likely to benefit from early surgical intervention, and (3) potentially screen for asymptomatic children at risk of developing idiopathic scoliosis.

Sponsor: University of Colorado, Denver · Participants: 380 · Started: 2016-11

Contact the study team

• jiandong hao · Phone: 303-724-7457

Official record on ClinicalTrials.gov — NCT02315729

Locations in the U.S.

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.