Home › NCT02316379

Use of Hyperpolarized 129Xe MR Lung Imaging in Adults for Calibration

Who can join

Ages 18 and older · All sexes · Healthy volunteers welcome

Inclusion Criteria:

* Adults ages 18 years and older
* Participant must be able to hold their breath for up to 16 seconds

Exclusion Criteria:

* History of heart defect
* Pregnancy or positive pregnancy test
* History of uncontrolled asthma defined for this study as requiring use of rescue inhaler ≥ 2 times in past month.
* Symptoms of respiratory infection (loose or productive cough or wheeze), chest tightness, or sinus infection within past week.
* Baseline oximetry at MRI visit of less than 95% on room air or less than 95% on a previously prescribed dosage of oxygen delivered by nasal cannula.
* Participant is claustrophobic and unable to tolerate the imaging.
* Standard MRI exclusions (metal, implants).

About the study

The goal of this study is to evaluate the usefulness of hyperpolarized (HP) 129Xe (xenon) gas MRI for regional assessment of lung function in a normal population of adults for the purposes of obtaining optimal images through MRI.

What is being tested

• Hyperpolarized 129 Xenon (drug)
• MRI (device)

Sponsor: Children's Hospital Medical Center, Cincinnati · Participants: 100 · Started: 2015-02

Contact the study team

• Carrie Stevens, BS · Phone: 513-636-9973
• Kelly Thornton, BS · Phone: 513-636-0604

Official record on ClinicalTrials.gov — NCT02316379

Locations in the U.S.

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.