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Longitudinal Study of Intra-Uterine Growth Restriction

Longitudinal Study of Intra-Uterine Growth Restriction (IUGR)

Who can join

Ages 18 to 45 · Women

Inclusion Criteria:

* Patients with diagnosed SGA by an ultrasound estimated fetal weight (EFW) of less than the 10th percentile or a fetal abdominal circumference of less than the 5th percentile will be included in the study at the time of their first examination.

Exclusion Criteria:

* Patients \< 18 years of age, and chromosomal anomalies as identified by regular aneuploidy screening.

About the study

The investigation will employ a longitudinal approach in which every fetus diagnosed to be SGA (Small for Gestational Age ) will be studied at frequent intervals with sophisticated imaging techniques to assess subtle physiologic changes in the brain, heart, and placenta over time. These findings will be correlated with neurological and cardiovascular function in the newborn and early childhood. This research initiative should yield diagnostic and therapeutic templates that will improve the quality of life of IUGR babies in addition to providing important information that will better inform current diagnostic practices.

What is being tested

• Ultrasound (radiation)
• MRI (radiation)
• Blood collection (procedure)
• Neurological Function Assessment (behavioral)
• Placental Analysis (procedure)
• Measurement of body fat (procedure)

Sponsor: University of Colorado, Denver · Participants: 200 · Started: 2015-04

Contact the study team

Official record on ClinicalTrials.gov — NCT02382601

Locations in the U.S.

From ClinicalTrials.gov, data retrieved Oct 3, 2026. Each study sets its own eligibility; the study team decides who can join.