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Effects of High Altitude on AMPK Activation
Effects of High Altitude on 5' Adenosine Monophosphate-activated Protein Kinase (AMPK) Activation and Peroxisome Proliferator-activated Receptor Gamma (PPARγ) Regulation
Who can join
Ages 18 to 45 · Women · Healthy volunteers welcome
Full eligibility criteria
Inclusion Criteria: * Women scheduled for cesarean delivery at University of Colorado Hospital (Denver, 1600 m) and St. Anthony's Summit Medical Center (Summit County, 3000 m) * Cesarean delivery at a prescheduled time without any labor, typically at 39 weeks gestation Exclusion Criteria: * Women will be excluded if there are co-existing medical diagnoses that are known to affect vascular parameters (i.e., diabetes mellitus, gestational diabetes, any hypertensive disorder of pregnancy, or a current smoker). * Women with multiple gestations and preterm deliveries will also be excluded.
About the study
Pregnancy elicits adaptive changes in uteroplacental blood flow, which are altered at high altitude and may contribute to the observed 3-fold increase in intrauterine growth restriction (IUGR) and preeclampsia (PreE). The investigators propose to collect myometrial, cord blood, and placental tissue samples from women at high altitude (Summit County) and low altitude (Denver) in Colorado in order to determine if residence at altitude during pregnancy changes the vasoreactivity of myometrial arteries (MA). If altered MA vasoreactivity is found, further studies may be able to link these changes to the increased rates of PreE and IUGR at altitude and contribute to the understanding of these two disorders.
What is being tested
- Collection of myometrial, cord blood, and placental tissue samples (procedure)
Sponsor: University of Colorado, Denver · Participants: 84 · Started: 2016-01
Contact the study team
- Lorna Moore, PhD · Phone: 303-724-7474
Official record on ClinicalTrials.gov — NCT02391519
Locations in the U.S.
| Colorado | University of Colorado Denver Anschutz Medical Campus, Aurora |
Conditions
From ClinicalTrials.gov, data retrieved Oct 2, 2026. Each study sets its own eligibility; the study team decides who can join.