Home › Fetal Growth Retardation › NCT02639312

Natural History of Craniofacial Anomalies and Developmental Growth Variants

Who can join

Ages 2 to 100 · All sexes · Healthy volunteers welcome

* INCLUSION CRITERIA:

For Subjects:

* Age \> 2 to \< 100 with craniofacial anomalies/abnormalities. Affected family member (defined as an individual with a demonstrable relationship, any family relationship no matter how distant, with the above subject in the pedigree) who expresses craniofacial anomalies will be classified as a subject.
* Able to provide consent, or in the case of minors, have a legally authorized representative to provide consent.

For Unaffected Family Members:

* These family members are defined as individuals with a demonstrable relationship (any family relationship, no matter how distant) with a proband subject by pedigree who do not express craniofacial anomalies.
* \>= 2 years old to \<= 100 years old.
* Able to provide consent, or in the case of minors, have a legally authorized representative to provide consent.

For Healthy Volunteers:

* In good general health.

  -\>= 6 years old to \< 100 years old.
* Able to provide consent, or in the case of minors, have a legally authorized representative to provide consent.
* Absence of a craniofacial congenital anomaly or malocclusion.
* No family history of a craniofacial syndrome.

EXCLUSION CRITERIA:

An individual who meets any of the following criteria will be excluded from participation in this study:

For All Participants:

* A history of facial trauma requiring surgical treatment and facial reconstruction.
* Refusal for both genetic testing and CBCT imaging. Participants must agree to at least one of the two (one or the other is required to participate).

For Healthy Volunteers:

-Female volunteers who are pregnant or nursing.

About the study

Background:

Some head and facial abnormalities are rare and present at birth. Others are more common, and may not show up until puberty. These conditions have different causes and characteristics. Researchers want to learn more about these conditions by comparing people with face, head, and neck abnormalities to family members and to healthy volunteers without such conditions.

Objectives:

To learn more about abnormal development of the face, head, and neck. To determine their genetic variants.

Eligibility:

People who have not had surgery for facial trauma:

People ages 2 and older with craniofacial abnormalities (may participate offsite)

Unaffected relatives ages 2 and older

Healthy volunteers ages 6 and older

Design:

Participants will be screened with medical history and physical exam focusing on head, face, and neck

Participants may be followed for several years. Visits may require staying near the clinic for a few days.

A visit is required for the following developmental stages, along with follow-up visits:

Age 2-6

Age 6-10

Age 11-17

Age 18 and older

Visits may include:

Medical history

Physical exam

Questionnaires

Oral exam

Blood and urine tests

Cheek swab: a cotton swab will be wiped across the inside of the cheek several times.

Cone beam CT scan (CBCT): x-rays create an image of the head, face, teeth, and neck. Participants will

stand still or sit on a chair for about 20 minutes while the scanner rotates around the head.

Photos of the head and face

Offsite participants will provide:

Copies of medical and dental records

Leftover tissue samples from previous surgery

Blood sample or cheek swab

Sponsor: National Institute of Dental and Craniofacial Research (NIDCR) · Participants: 2,400 · Started: Apr 18, 2016

Contact the study team

• Pamela M Orzechowski, R.N. · Phone: (301) 402-7373
• Konstantinia Almpani, D.D.S. · Phone: (301) 827-1647

Official record on ClinicalTrials.gov — NCT02639312

Locations in the U.S.

Conditions

• Fetal Growth Retardation

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.